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38 Results for "

ATP active site

" in MedChemExpress (MCE) Product Catalog:

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PHA-665752

17 Publications Verification

Cat. No.: HY-11107

CAS No.: 477575-56-7

Purity: 99.86%

Target:

c-Met/HGFR Autophagy Apoptosis

Research Areas:

Cancer

PHA-665752 is a selective, ATP-competitive, and active-site inhibitor of the catalytic activity of c-Met kinase (K_i=4 nM; IC₅₀=9 nM). PHA-665752 exhibits >50-fold selectivity for c-Met compared with a panel of diverse tyrosine and serine-threonine kinases. PHA-665752 induces apoptosis and cell cycle arrest, and exhibits cytoreductive antitumor activity .

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August 31

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Inavolisib

11 Cited Publications

Cat. No.: HY-101562

CAS No.: 2060571-02-8

Purity: 99.96%

Synonyms: GDC-0077; RG6114

Target:

PI3K Apoptosis

Research Areas:

Cancer

Inavolisib (GDC-0077) is a potent, orally active, and selective PI3Kα inhibitor (IC₅₀=0.038 nM). Inavolisib exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. Inavolisib is more selective for mutant versus wild-type PI3Kα. Inavolisib can be used for the study of breast cancer .

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