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111 Results for "

ATP binding site

" in MedChemExpress (MCE) Product Catalog:

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135

Imatinib

135 Publications Verification

Cat. No.: HY-15463

CAS No.: 152459-95-5

Purity: 99.95%

Synonyms: STI571; CGP-57148B

Target:

Bcr-Abl PDGFR c-Kit SARS-CoV Autophagy

Research Areas:

Cancer

Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively . Imatinib also is an inhibitor of SARS-CoV and MERS-CoV .

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August 31

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Inavolisib

11 Cited Publications

Cat. No.: HY-101562

CAS No.: 2060571-02-8

Purity: 99.96%

Synonyms: GDC-0077; RG6114

Target:

PI3K Apoptosis

Research Areas:

Cancer

Inavolisib (GDC-0077) is a potent, orally active, and selective PI3Kα inhibitor (IC₅₀=0.038 nM). Inavolisib exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. Inavolisib is more selective for mutant versus wild-type PI3Kα. Inavolisib can be used for the study of breast cancer .

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