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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
ATR-Chk1
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "ATR-Chk1" in MCE Product Catalog:
Cat. No.: HY-164496
CAS No.: 1161826-19-2
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KL-50 is an orally active N3-(2-fluoroethyl) imidazotetrazine DNA alkylating agent with selectivity for MGMT-deficient cells. KL-50 introduces a 2-fluoroethyl group at the O6 position of guanine, forming O6-(2-fluoroethyl) guanine (O6FEtG) lesions and further generating DNA interstrand crosslinks (ICLs). KL-50 induces DNA double-strand breaks, activates ATR-CHK1 and ATM-CHK2 DNA damage responses, and causes cell cycle arrest and micronucleus formation. KL-50 can be used for glioblastoma and DNA damage response research [1] .
Cat. No.: HY-147021
CAS No.: 1350456-66-4
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MC-Val-D-Cit-PAB-PNP is a peptide linker that can be used for the synthesis of Antibody-Drug Conjugates (ADCs). MC-Val-D-Cit-PAB-PNP can be used to construct antibody-drug conjugates loaded with ATR/CHK1 inhibitors [1].
Cat. No.: HY-147021A
CAS No.: 1350456-64-2
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MC-D-Val-Cit-PAB-PNP is a peptide linker that can be used for the synthesis of Antibody-Drug Conjugates (ADCs). MC-D-Val-Cit-PAB-PNP can be used to construct antibody-drug conjugates loaded with ATR/CHK1 inhibitors [1].
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LSD1/TLK1-IN-1 is an orally active LSD1, TLK1, TLK2, TTK inhibitor with an LSD1 IC50 of 0.247 μM. LSD1/TLK1-IN-1 suppresses phosphorylation of Nek1 at T141 and Rad9 at S328, abrogates the TLK1>Nek1>ATR>Chk1 axis, protects H3K4me1/2 from demethylation, and does not affect LSD2, MAO-A, or MAO-B. LSD1/TLK1-IN-1 induces apoptosis, bypasses cell-cycle arrest, suppresses tumor growth, downregulates PD-L1 expression, enhances T-cell killing response, inhibits gastric cancer cell proliferation. LSD1/TLK1-IN-1 can be used for the research of prostate cancer and gastric cancer [1] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
