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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
ATXN3
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "ATXN3" in MCE Product Catalog:
Cat. No.: HY-RS01258
Target:
Research Areas:
ATXN3 Human Pre-designed siRNA Set A contains three designed siRNAs for ATXN3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19985
Target:
Research Areas:
Atxn3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Atxn3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS26489
Target:
Research Areas:
Atxn3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Atxn3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS01259
Target:
Research Areas:
ATXN3L Human Pre-designed siRNA Set A contains three designed siRNAs for ATXN3L gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-189126
CAS No.: 1240580-64-6
Research Areas:
YL064 is a multi-target STAT3-c-MYC inhibitor that directly binds to ATXN3 and inhibits its deubiquitinating activity, thereby promoting the ubiquitination and proteasomal degradation of oncogenic substrates of ATXN3. YL064 inhibits the phosphorylation of STAT3-Tyr705 without altering the total protein level of STAT3; meanwhile, it directly binds to the SH2 domain of STAT3 to block the dimerization, nuclear translocation, and DNA-binding activity of STAT3. YL064 directly targets the C-terminal HLH-Zip domain of c-Myc, upregulates the phosphorylation of c-Myc at the Thr58 site, and induces the ubiquitination and proteasome-dependent degradation of c-Myc. YL064 suppresses tumor cell proliferation, induces G2/M cell cycle arrest, reduces cell migration and invasion capacities, and triggers cancer cell apoptosis. YL064 can be used in related research on breast cancer, prostate cancer, diffuse large B-cell lymphoma, and multiple myeloma [3].
Cat. No.: HY-P79456
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ATXN3; MJD1; Prev. SCA3; Olivopontocerebellar Ataxia 3; Prev. MJD; Ubiquitinyl Hydrolase 1; ATX3; Ataxin 3 Variant An; JOS; Ataxin 3 Variant H; Spinocerebellar Ataxia Type 3 Protein; Ataxin 3 Variant E; Machado-Joseph Disease Protein 1; Josephin; Ataxin-3
Species:
Human
Source:
E. coli
Cat. No.: HY-P701460
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ATXN3L; Ataxin-3-Like Protein; Ataxin 3 Like; Putative Ataxin-3-Like Protein; MJDL; Ataxin 3-Like; Machado-Joseph Disease Protein 1-Like; ATX3L
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701461
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ATXN3L; Ataxin-3-Like Protein; Ataxin 3 Like; Putative Ataxin-3-Like Protein; MJDL; Ataxin 3-Like; Machado-Joseph Disease Protein 1-Like; ATX3L
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
