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297 Results for "

Actin

" in MedChemExpress (MCE) Product Catalog:

Products (297)

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111

Cytochalasin D

111 Publications Verification

Cat. No.: HY-N6682

CAS No.: 22144-77-0

Synonyms: Zygosporin A; NSC 209835

Category:

Infection Natural Products Microorganisms Disease Research Fields

Target:

Exosomes Arp2/3 Complex Antibiotic YAP

Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .

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BAY-876

63 Cited Publications

Cat. No.: HY-100017

CAS No.: 1799753-84-6

Purity: 99.67%

Target:

GLUT Disulfidptosis

Research Areas:

Cancer

BAY-876, a chemical probe, is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC₅₀ of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. In addition, BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis .

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Cytochalasin B

48 Cited Publications

Cat. No.: HY-16928

CAS No.: 14930-96-2

Synonyms: Phomin

Category:

Natural Products Microorganisms Disease Research Fields Cancer

Target:

Arp2/3 Complex

Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, disrupting the formation of actin polymers, with K_d value of 1.4-2.2 nM for F-actin. Cytochalasin B blocks cell migration.

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BRM/BRG1 ATP Inhibitor-1

46 Cited Publications

Cat. No.: HY-119374

CAS No.: 2270879-17-7

Purity: 99.72%

Target:

SWI/SNF Complex

Research Areas:

Cancer

BRM/BRG1 ATP Inhibitor-1 (compound 14) is an orally active allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, both IC₅₀s are below 0.005 µM. BRM/BRG1 ATP Inhibitor-1 has anticancer activity .

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CK-666

31 Cited Publications

Cat. No.: HY-16926

CAS No.: 442633-00-3

Target:

Arp2/3 Complex HIV

Research Areas:

Infection Cancer

CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor (IC₅₀=12 μM). CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation .

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