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Acute Leukemia

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166

Navitoclax dihydrochloride

166 Publications Verification

Cat. No.: HY-10087A1

CAS No.: 1093851-28-5

Synonyms: ABT-263 dihydrochloride

Target:

Bcl-2 Family Apoptosis Survivin TGF-β Receptor

Research Areas:

Cardiovascular Disease Cancer

Navitoclax dihydrochloride (ABT-263 dihydrochloride) is an orally active BH3 mimetic and an inhibitor of Bcl-2, Bcl-xL, and Bcl-w, with a K_i value of <1 nM for each target. Navitoclax dihydrochloride triggers endogenous Apoptosis and downregulates the expression of Survivin and TGFβ2. Navitoclax dihydrochloride alleviates fibrosis and induces thrombocytopenia. Navitoclax dihydrochloride exhibits anticancer activity against a variety of tumors and enhances the efficacy of chemotherapy and radiotherapy. Navitoclax dihydrochloride can be used in the research of acute lymphoblastic leukemia, ovarian cancer, and fibrotic diseases .

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