2 Results for "

Agrimonolide

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Agrimonolide" in MCE Product Catalog:

1
Agrimonolide
Agrimonolide
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Cat. No.: HY-N2830
CAS No.: 21499-24-1
Category:  

Plant Other Diseases Rosaceae Extract Phenols Polyphenols Disease Research Fields

Target:  

NF-κB Ferroptosis MAPKAPK2 (MK2) Toll-like Receptor (TLR) Notch JAK STAT HIF/HIF Prolyl-Hydroxylase

Agrimonolide is a phenethyl isocoumarin compound discovered from Agrimonia pilosa, exhibiting anti-inflammatory, antioxidant, and anticancer activities. Agrimonolide inhibits NF-κB, MAPK, and TLR4-mediated neuroinflammatory signaling, suppresses Notch and JAK2/STAT3 signaling to modulate Th17/Treg balance and maintain the intestinal barrier. Agrimonolide decreases HIF1A expression, inhibits glycolysis, and induces ferroptosis and cell cycle arrest via the mTOR pathway in tumor models, thereby suppressing cancer cell viability, proliferation, and metastasis. Agrimonolide exerts hepatoprotective and anti-fibrotic effects by regulating bile acid transporter expression and reducing hepatic bile acid accumulation. Agrimonolide is used for research on ulcerative colitis, ovarian cancer, non-small cell lung cancer, cholestatic liver injury, and neuroinflammation .
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Agrimonolide 6-O-β-D-glucoside
Agrimonolide 6-O-β-D-glucoside
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Cat. No.: HY-N2831
CAS No.: 126223-29-8
Category:  

Plant Agrimonia pilosa Ledeb. Extract Monophenols Rosaceae Extract Phenols

Target:  

Others

Agrimonolide 6-O-β-D-glucoside is a isocoumarin that can be isolated from Agrimonia pilosa. Agrimonolide 6-O-β-D-glucoside is used in hepatic disease research .
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