5105 Results for "

Anticancer

" in MedChemExpress (MCE) Product Catalog:

Products (5105)

Sort by :

Categories

By Targets

Products

728

Doxorubicin hydrochloride

728 Publications Verification

Cat. No.: HY-15142

CAS No.: 25316-40-9

Purity: 99.90%

Synonyms: Hydroxydaunorubicin hydrochloride; ADR

Category:

Infection Quinones Microorganisms Anthraquinones Disease Research Fields

Target:

Topoisomerase ADC Payloads AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Fluorescent Dye

Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

Compare

Please select quantity

August 31

Get Quote

View All Sizes

466

Deferoxamine mesylate

466 Cited Publications

Cat. No.: HY-B0988

CAS No.: 138-14-7

Synonyms: Desferrioxamine B mesylate; DFOM

Target:

Autophagy HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Apoptosis Akt

Research Areas:

Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Deferoxamine mesylate (Deferoxamine B mesylate) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine mesylate upregulates HIF-1α levels with good antioxidant activity. Deferoxamine mesylate also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine mesylate can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 .

Compare

Please select quantity

August 31

Get Quote

View All Sizes

466

Deferoxamine

466 Cited Publications

Cat. No.: HY-B1625

CAS No.: 70-51-9

Synonyms: Deferoxamine B; Deferriferrioxamine B; Deferrioxamine

Target:

HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Apoptosis Akt Autophagy

Research Areas:

Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 .

Compare

Please select quantity

August 31

Get Quote

View All Sizes

286

Bortezomib

286 Cited Publications

Cat. No.: HY-10227

CAS No.: 179324-69-7

Purity: 99.91%

Synonyms: PS-341; LDP-341; NSC 681239

Target:

Proteasome NF-κB Apoptosis Autophagy TREM receptor Ligands for Target Protein for PROTAC

Research Areas:

Cancer

Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (K_i=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM) . Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs) .

Compare

Please select quantity

August 31

Get Quote

View All Sizes

264

Nigericin sodium salt

264 Cited Publications

Cat. No.: HY-100381

CAS No.: 28643-80-3

Purity: 99.37%

Category:

Infection Microorganisms Antibiotics Disease Research Disease Research Fields Other Antibiotics Cancer

Target:

Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin

Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K ⁺/H ⁺ ionophore, promoting K ⁺/H ⁺ exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC .

Compare

Please select quantity

August 31

Get Quote

View All Sizes

264

Nigericin

264 Cited Publications

Cat. No.: HY-127019

CAS No.: 28380-24-7

Purity: 99.43%

Target:

Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin

Research Areas:

Infection Cancer

Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K ⁺/H ⁺ ionophore, promoting K ⁺/H ⁺ exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin induces pyroptosis through caspase 1/GSDMD in TNBC .

Compare

Please select quantity

August 31

Get Quote

View All Sizes

202

Doxycycline

202 Cited Publications

Cat. No.: HY-N0565

CAS No.: 564-25-0

Target:

MMP Bacterial Antibiotic Parasite

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline shows antibacterial activity and anti-cancer cell proliferation activity .

Compare

Please select quantity

August 31

Get Quote

View All Sizes

202

Doxycycline hydrochloride

202 Cited Publications

Cat. No.: HY-N0565A

CAS No.: 10592-13-9

Target:

MMP Bacterial Antibiotic Parasite

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor . Doxycycline hydrochloride shows antibacterial activity and anti-cancer cell proliferation activity. Doxycycline hydrochloride can be used to construct gene expression regulation models .

Compare

Please select quantity

August 31

Get Quote

View All Sizes

202

Doxycycline hyclate

202 Cited Publications

Cat. No.: HY-N0565B

CAS No.: 24390-14-5

Synonyms: Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031

Target:

Antibiotic MMP Bacterial Parasite

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity. Doxycycline hyclate can be used to construct gene expression regulation models .

Compare