33

Clopidogrel hydrogen sulfate

33 Publications Verification

Cat. No.: HY-17459

CAS No.: 120202-66-6

Synonyms: (S)-(+)-Clopidogrel bisulfate; (S)-(+)-Clopidogrel hydrogen sulfate

Target:

Cytochrome P450 P2Y Receptor

Research Areas:

Cardiovascular Disease Cancer

Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC₅₀s of 18.2 nM and 524 nM, respectively . Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation ．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor .

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12

Vorapaxar

12 Cited Publications

Cat. No.: HY-10119

CAS No.: 618385-01-6

Purity: 99.79%

Synonyms: SCH 530348

Target:

Protease Activated Receptor (PAR)

Research Areas:

Cardiovascular Disease

Vorapaxar (SCH 530348), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (K_i=8.1 nM). Vorapaxar (SCH 530348) inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner .

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12

Dipyridamole

12 Cited Publications

Cat. No.: HY-B0312

CAS No.: 58-32-2

Target:

Phosphodiesterase (PDE) Apoptosis

Research Areas:

Cardiovascular Disease Cancer

Dipyridamole is an orally active phosphodiesterase (PDE) inhibitor. Dipyridamole also is an antiplatelet agent used in secondary prophylaxis against stroke. Dipyridamole can induce cancer cell-specific apoptosis .

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12

Vorapaxar sulfate

12 Cited Publications

Cat. No.: HY-10119A

CAS No.: 705260-08-8

Purity: 99.81%

Synonyms: SCH 530348 sulfate

Target:

Protease Activated Receptor (PAR)

Research Areas:

Cardiovascular Disease

Vorapaxar sulfate (SCH 530348 sulfate), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (K_i=8.1 nM). Vorapaxar sulfate inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner .

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4

MNS

4 Cited Publications

Cat. No.: HY-78263

CAS No.: 1485-00-3

Synonyms: NSC 170724; 5-(2-Nitrovinyl)benzodioxole

Target:

Src Syk NOD-like Receptor (NLR) Integrin PANoptosis

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

MNS (NSC 170724), the beta-nitrostyrene derivative, is an orally active tyrosine kinase inhibitor, a broad-spectrum antiplatelet agent, and a PANoptosis inhibitor. MNS inhibits Src, Syk, and FAK with IC₅₀ of 27.3, 2.8, and 97.6 μM, respectively. MNS inhibits NLRP3 inflammasome and β1 integrin. MNS completely inhibits U46619, ADP-, arachidonic acid-, collagen-, and thrombin-induced platelet aggregation with IC₅₀ values of 2.1, 4.1, 5.8, 7.0, and 12.7 μM, respectively. MNS is cytotoxic to a variety of cells .

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2

Vicagrel

2 Cited Publications

Cat. No.: HY-118284

CAS No.: 1314081-53-2

Purity: 98.86%

Target:

P2Y Receptor

Research Areas:

Cardiovascular Disease

Vicagrel is a potent, safe and orally active antiplatelet agent, which works by irreversibly inhibiting P2Y12 receptor. Vicagrel can be used for the research of blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease .

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Trapidil

Cat. No.: HY-B1016

CAS No.: 15421-84-8

Synonyms: AR-12008

Target:

PDGFR Phosphodiesterase (PDE) Prostaglandin Receptor

Research Areas:

Cardiovascular Disease Neurological Disease

Trapidil (AR-12008) is an orally active vasodilator and antiplatelet agent. Trapidil antagonizes platelet-derived growth factor (PDGF), inhibits phosphodiesterase, thromboxane A₂ synthesis and pro-inflammatory cytokine production. Trapidil promotes prostacyclin biosynthesis, reduces lipid peroxidation, regulates nitric oxide metabolism, and inhibits cell proliferation and migration. Trapidil exerts tissue-protective effects, regulates bone turnover, and inhibits pyroptosis via the GPX3/Nrf2 pathway. Trapidil is applicable to research related to renal ischemia-reperfusion injury, chronic stable angina, restenosis, meningioma, diabetic cardiomyopathy and peripheral nerve crush injury .

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Ridogrel

Cat. No.: HY-A0221

CAS No.: 110140-89-1

Synonyms: R 68070

Target:

Prostaglandin Receptor

Research Areas:

Inflammation/Immunology

Ridogrel (R 68070) is an orally active combined thromboxane A2 synthetase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor blocker. Ridogrel is potent antiplatelet agent. Anti-inflammatory activities .

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Atopaxar

Cat. No.: HY-18200

CAS No.: 751475-53-3

Synonyms: E5555; ER-172594-00

Target:

Protease Activated Receptor (PAR) JAK Apoptosis

Research Areas:

Cardiovascular Disease Cancer

Atopaxar (E5555) is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist. Atopaxar, an antiplatelet agent, interferes with platelet signaling. Atopaxar can be used for the research of atherothrombotic disease .

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trans-R-138727

Cat. No.: HY-123669A

CAS No.: 239466-74-1

Purity: 98.98%

Target:

P2Y Receptor

Research Areas:

Cardiovascular Disease

Trans-R-138727 is the trans isomer of R-138727 (HY-123669). R-138727 is the active metabolite of the antiplatelet agent Prasugrel (HY-15284). R-138727 is an irreversible inhibitor for the platelet receptor P2Y12, and inhibits ADP-induced platelet activation and aggregation .

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(±)-2-Oxo clopidogrel

Cat. No.: HY-118025

CAS No.: 109904-27-0

Purity: 99.67%

Synonyms: (±)-SR-121683

Target:

Drug Metabolite

Research Areas:

Others

(±)-2-Oxo clopidogrel is a metabolite of the antiplatelet agent Clopidogrel (HY-15283) .

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NCGC00351170

Cat. No.: HY-162558

CAS No.: 886536-76-1

Target:

Factor Xa

Research Areas:

Cardiovascular Disease

NCGC00351170 is an antiplatelet agent that disrupts the calcium and integrin-binding protein 1 (CIB1)-α_IIbβ₃ interaction. NCGC00351170 inhibits thrombin-induced human platelet aggregation .

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