17

Dooku1

17 Publications Verification

Cat. No.: HY-126010

CAS No.: 2253744-54-4

Purity: 99.93%

Target:

Piezo Channel

Research Areas:

Others

Dooku1 is a reversibly Yoda1 antagonist with IC₅₀ value of 1.3 μM and 1.5 μM for 2 μM Yoda1-induced Ca ²⁺ entry HEK 293 cells and HUVECs, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research .

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7

Cyclopiazonic acid

7 Cited Publications

Cat. No.: HY-N6771

CAS No.: 18172-33-3

Category:

Alkaloids Microorganisms Pyrrole Alkaloids Other Diseases Disease Research Fields Indole Alkaloids

Target:

Calcium Channel 5-HT Receptor MDM-2/p53 Apoptosis RSV

Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC₅₀ value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B ^[1][4][5].

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7

alpha smooth muscle Actin Antibody (YA627)

7 Cited Publications

Cat. No.: HY-P80484

Synonyms: alpha sarcomeric Actin; alpha smooth muscle Actin; Actin alpha; ASMA; ASM-A; alpha-SMA; alpha SMA; AAT6; ACTA2; Actin alpha 2 smooth muscle Aorta; Actin aortic smooth muscle; ACTSA; ACTVS; Alpha 2 actin; Alpha-actin 2; Cell growth inhibiting gene 46 protein; Growth inhibiting gene 46; ACTA_HUMAN; Actin alpha 2 smooth muscle Aorta; Actin aortic smooth muscle; Actin, aortic smooth muscle; Alpha 2 actin; Alpha actin 2; Alpha cardiac actin; Alpha-actin 2; Alpha-actin-2; Cell growth inhibiting gene 46 protein; Cell growth-inhibiting gene 46 protein; Growth inhibiting gene 46; MYMY5 α-Smooth Muscle Actin; α Smooth Muscle Actin;

Host:

Rabbit

Application:

WB, IHC-P, FC, IP

Reactivity:

Human, Mouse

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5

E7820

5 Cited Publications

Cat. No.: HY-14571

CAS No.: 289483-69-8

Purity: 99.06%

Synonyms: ER68203-00

Target:

Molecular Glues Integrin

Research Areas:

Infection Metabolic Disease Cancer

E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a molecular glue that induces the targeted degradation of splicing factor RBM39 by recruiting the E3 ubiquitin ligase CUL4-RBX1-DDB1-DCAF15 (CRL4 ^DCAF15). E7820 is an angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC₅₀ of 0.11 μg/ml. E7820 modulates α-1, α-2, α-3, and α-5 integrin mRNA expression. E7820 can be used for the study of acute myeloid leukemia (AML) .

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1

(D-Pro7)-Angiotensin I/II (1-7)

1 Cited Publications

Cat. No.: HY-P1656

CAS No.: 586962-44-9

Target:

Angiotensin Receptor Mas-related G-protein-coupled Receptor (MRGPR)

Research Areas:

Cardiovascular Disease

(D-Pro7)-Angiotensin I/II (1-7) is a potent Mas receptor inhibitor with a K_i of 0.001 μM for rat receptors. (D-Pro7)-Angiotensin I/II (1-7) competitively blocks the binding of Angiotensin-(1-7) to the Mas receptor and attenuates the vasodilatory effect of rat aortas under physiological and hypertensive conditions. (D-Pro7)-Angiotensin I/II (1-7) can be used for studies on the function of the renin-angiotensin system and the pathological mechanisms of hypertension .

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1

Mergetpa

1 Cited Publications

Cat. No.: HY-W704574

CAS No.: 77102-28-4

Target:

Carboxypeptidase Bradykinin Receptor Interleukin Related

Research Areas:

Cardiovascular Disease Metabolic Disease

Mergetpa is a reversible Arg-carboxypeptidase inhibitor with high affinity. Mergetpa reduces B1R. Mergetpa blocks the overexpression of IL-1β protein and mRNA in glucose-fed rats. Mergetpa significantly increases the expression of IL-1β protein in the renal cortex. Mergetpa is used to block the conversion of kinins and B2 receptor antagonists into metabolites lacking the C-terminal arginine. Mergetpa inhibits the time-dependent enhancement of the response of isolated rabbit aorta to bradykinin. Mergetpa preserves the chemotactic activity of full-length SDF-1α on cells. Mergetpa reverses hyperglycemia, excessive weight gain, elevated levels of oxidative stress markers and overexpression of inflammatory markers in glucose-fed rats .

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1

Collagenase (Type B, animal free)

1 Cited Publications

Cat. No.: HY-E70005L

CAS No.: 9001-12-1

Target:

Proteasome

Research Areas:

Metabolic Disease

Collagenase (Type B, animal free) is an animal-free collagen-degrading digestive enzyme and tissue dissociation reagent. Collagenase (Type B, animal free) can digest mouse aorta, myocardium, human umbilical cord, and human liver tissue to isolate primary leukocytes, adult mouse cardiomyocytes, human mesenchymal stem cells, and individual hepatocytes. Collagenase (Type B, animal free) can be used in studies related to liver cirrhosis .

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Piclamilast

Cat. No.: HY-12887

CAS No.: 144035-83-6

Purity: 99.74%

Synonyms: RP 73401; RPR 73401

Target:

Phosphodiesterase (PDE)

Research Areas:

Inflammation/Immunology Cancer

Piclamilast (RP 73401) is a phosphodiesterase 4 (PDE4) inhibitor, with IC₅₀ values of 16 nM and 2 nM in pig aorta and eosinophil soluble, respectively .

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Satralizumab

Cat. No.: HY-P99112

CAS No.: 1535963-91-7

Synonyms: RG-6168; SA-237

Satralizumab is a humanized monoclonal antibody that targets IL-6R. Satralizumab prevents dTAA formation and progression in rattus norvegicus. Satralizumab can be used for neuromyelitis optica spectrum disorder (NMOSD) and descending thoracic aorta aneurysm (dTAA) research .

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H-8 dihydrochloride

Cat. No.: HY-112465

CAS No.: 113276-94-1

Purity: 99.00%

Target:

PKA PKC PKG

Research Areas:

Neurological Disease Cancer

H-8 dihydrochloride is a selective Cyclic nucleotide-dependent protein kinase inhibitor. H-8 dihydrochloride potently inhibits cGMP- and cAMP-dependent protein phosphorylation. H-8 dihydrochloride enhances the vasodilatory effect induced by 8-bromo-cAMP (HY-12306A). H-8 dihydrochloride fails to attenuate the vasodilatory effects induced by 8-bromo-cGMP (HY-101379A), atrial natriuretic peptide II, or Sodium nitroprusside (HY-B0564) in rat aorta .

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