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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
66 Results for "
ApoA
" in MedChemExpress (MCE) Product Catalog:
Products (66)
66 Results for "ApoA" in MCE Product Catalog:
3
3 Cited Publications
Cat. No.: HY-19900
CAS No.: 1252679-52-9
Research Areas:
ITX5061 is an orally active type II non-competitive p38 MAPK inhibitor. ITX5061 increases HDL-C levels by inhibiting SR-BI activity. ITX5061 also moderately elevates ApoA-I levels. ITX5061 reduces early atherosclerotic lesions in the aortic arch of mice fed an atherogenic diet. ITX5061 can be used in the research of atherosclerosis .
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Cat. No.: HY-P5282
CAS No.: 221882-20-8
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Cat. No.: HY-147425
CAS No.: 2646703-64-0
Synonyms: SLN360
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Zerlasiran (SLN360) is a siRNA targeting apolipoprotein A (ApoA). Zerlasiran targets hepatic ApoA synthesis via RNA interference to degrade encoding mRNA. Zerlasiran can be used for the research of atherosclerotic cardiovascular disease and elevated ApoA levels .
Cat. No.: HY-P10551
Research Areas:
ApoA-I mimetic peptide 5A is an ApoA-I mimetic peptide and ABCA1 activator. ApoA-I mimetic peptide 5A enhances CD36 expression through the JAK2/STAT3 signaling pathway. ApoA-I mimetic peptide 5A promotes cholesterol efflux, remyelination, and myelin debris clearance/degradation. ApoA-I mimetic peptide 5A can be used in research on inflammatory bowel disease, demyelinating diseases, and atherosclerosis .
Cat. No.: HY-147425A
Purity: 95.52%
Synonyms: SLN360 sodium
Research Areas:
Zerlasiran (SLN360) sodium is a siRNA targeting apolipoprotein A (ApoA). Zerlasiran sodium targets hepatic ApoA synthesis via RNA interference to degrade encoding mRNA. Zerlasiran sodium can be used for the research of atherosclerotic cardiovascular disease and elevated ApoA levels .
Cat. No.: HY-P6365B
CAS No.: 452782-06-8
Synonyms: D-4F
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Cat. No.: HY-171464
CAS No.: 2924841-79-0
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Lp(a)-IN-5 (Compound A) is an orally active lipoprotein (a) (Lp(a)) inhibitor. Lp(a)-IN-5 inhibits the assembly of Apo(a) and ApoB proteins with an IC50 value of 0.41 nM. Lp(a)-IN-5 is promising for research of diseases related to elevated plasma Lp(a) levels, such as cardiovascular diseases .
Cat. No.: HY-P6365
Synonyms: L-4F TFA
APL180 TFA (L-4F TFA) is an Apo-A1 mimetic peptide . APL180 TFA binds oxidized/oxidizable lipids with high affinity and sequesters pro-inflammatory oxidized lipids. APL180 TFA downregulates glycolysis-related genes and HIF-1α expression, and upregulates CD206 and Arginase. APL180 TFA inhibits atherosclerotic lesion progression and platelet aggregation. APL180 TFA attenuates adverse left ventricular remodeling and systolic dysfunction after myocardial infarction. APL180 TFA can be used for research on ovarian cancer .
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5(Z),11(Z),14(Z)-Eicosatrienoic acid (Sciadonic acid), a polyunsaturated fatty acid sourced from maritime pine seed oil, gymnospermae leaves and seeds, and freshwater gastropods, has been shown to reduce high-density lipoprotein and ApoA1 levels in transgenic mice expressing human ApoA1 when included in their diet. In vitro studies indicate that it diminishes cholesterol efflux, and when applied topically in its methyl ester form, it alleviates inflammatory processes, likely by displacing arachidonic acid from phospholipid pools and lowering concentrations of downstream inflammatory mediators such as prostaglandin E2 and leukotrienes.
Cat. No.: HY-171464A
CAS No.: 2924841-80-3
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Lp(a)-IN-5 (Compound A) hydrochloride is an orally active lipoprotein (a) (Lp(a)) inhibitor. Lp(a)-IN-5 hydrochloride inhibits the assembly of Apo(a) and ApoB proteins with an IC50 value of 0.41 nM. Lp(a)-IN-5 hydrochloride is promising for research of diseases related to elevated plasma Lp(a) levels, such as cardiovascular diseases .
Cat. No.: HY-113510
CAS No.: 89886-42-0
Cat. No.: HY-P991574
CAS No.: 2643310-75-0
Synonyms: REG-101
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Cat. No.: HY-W590664
CAS No.: 13031-64-6
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C2 Dihydroceramide is a derivative of C2 Ceramide (HY-101180). C2 Dihydroceramide enhances the ABCA1-mediated cholesterol efflux to apolipoprotein A-I (apoA-I) without causing cytotoxicity .
Synonyms: Ethyl pinolenate
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Pinolenic acid is a polyunsaturated fatty acid found in the seed oils of red pine (Pinus orientalis) and maritime pine (Pinus pinaster). Both oils were found to have lipid-lowering properties. A diet containing marine pine nut oil (MPSO) reduces HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to reduce cholesterol efflux in vitro. Korean pine nut oil supplements may help obesity by reducing appetite. People who take this oil experience an increase in the satiety hormones CCK and GLP-1 and a decrease in appetite. The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not metabolized to arachidonic acid and can reduce the level of arachidonic acid in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%. Pinolenic acid ethyl ester is a neutral, more lipophilic form of the free acid.
Cat. No.: HY-RS00829
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APOA1 Human Pre-designed siRNA Set A contains three designed siRNAs for APOA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P6365A
CAS No.: 388566-97-0
Synonyms: L-4F
Research Areas:
APL180 (L-4F) is an Apo-A1 mimetic peptide . APL180 binds oxidized/oxidizable lipids with high affinity and sequesters pro-inflammatory oxidized lipids. APL180 downregulates glycolysis-related genes and HIF-1α expression, and upregulates CD206 and Arginase. APL180 inhibits atherosclerotic lesion progression and platelet aggregation. APL180 attenuates adverse left ventricular remodeling and systolic dysfunction after myocardial infarction. APL180 can be used for research on ovarian cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
