78

Oseltamivir acid

78 Publications Verification

Cat. No.: HY-13318

CAS No.: 187227-45-8

Purity: 99.50%

Synonyms: GS 4071; Ro 64-0802; Oseltamivir carboxylate

Target:

Influenza Virus Drug Metabolite

Research Areas:

Infection Neurological Disease

Oseltamivir acid (GS 4071), the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC₅₀=2 nM) with activity against both influenza A and B viruses. Oseltamivir acid has an extremely weak ability to penetrate the BBB under normal physiological conditions, but its blood-brain barrier penetration is significantly enhanced under inflammatory conditions .

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55

Baloxavir

55 Cited Publications

Cat. No.: HY-109025A

CAS No.: 1985605-59-1

Purity: 99.68%

Synonyms: Baloxavir acid; S-033447

Target:

Influenza Virus

Research Areas:

Infection Cancer

Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .

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51

Oseltamivir

51 Cited Publications

Cat. No.: HY-13317

CAS No.: 196618-13-0

Purity: 99.94%

Synonyms: GS 4104

Target:

Influenza Virus

Research Areas:

Infection Cancer

Oseltamivir (GS 4104) is an orally active influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively .

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36

Pyridostatin trihydrochloride

36 Cited Publications

Cat. No.: HY-15176C

CAS No.: 2517456-88-9

Synonyms: RR82 trihydrochloride

Target:

DNA/RNA Synthesis G-quadruplex Flavivirus Src Virus Protease

Research Areas:

Cancer

Pyridostatin (RR82) trihydrochloride is a G-quadruplex (G4) inducer/stabilizer with a K_d of 490 nM. Pyridostatin trihydrochloride also acts as an inhibitor of Zika virus (ZIKV) NS2B-NS3 protease, with an IC₅₀ of 11.0 μM. Pyridostatin trihydrochloride interacts with G-quadruplex structures, regulates the expression of SRC and SUB1, and induces replication- and transcription-dependent DNA damage, growth arrest, and genomic instability. Pyridostatin trihydrochloride exhibits antiproliferative and antiviral activities. Pyridostatin trihydrochloride can be used in studies related to breast cancer, cervical cancer, and Zika virus infection .

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36

Pyridostatin TFA

36 Cited Publications

Cat. No.: HY-15176B

CAS No.: 1472611-44-1

Purity: 99.54%

Synonyms: RR82 TFA

Target:

DNA/RNA Synthesis G-quadruplex Flavivirus Src Virus Protease

Research Areas:

Cancer

Pyridostatin (RR82) TFA is a G-quadruplex (G4) inducer/stabilizer with a K_d of 490 nM. Pyridostatin TFA also acts as an inhibitor of Zika virus (ZIKV) NS2B-NS3 protease, with an IC₅₀ of 11.0 μM. Pyridostatin TFA interacts with G-quadruplex structures, regulates the expression of SRC and SUB1, and induces replication- and transcription-dependent DNA damage, growth arrest, and genomic instability. Pyridostatin TFA exhibits antiproliferative and antiviral activities. Pyridostatin TFA can be used in studies related to breast cancer, cervical cancer, and Zika virus infection .

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31

Ledipasvir D-tartrate

31 Cited Publications

Cat. No.: HY-15602B

CAS No.: 1502654-87-6

Purity: 98.76%

Synonyms: GS-5885 D-tartrate

Target:

HCV

Research Areas:

Infection

Ledipasvir D-tartrate is an inhibitor of the hepatitis C virus NS5A, with EC₅₀ values of 34 pM against GT1a and 4 pM against GT1b replicon.

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31

Ledipasvir (acetone)

31 Cited Publications

Cat. No.: HY-15602A

CAS No.: 1441674-54-9

Purity: 99.92%

Synonyms: GS-5885 (acetone)

Target:

HCV

Research Areas:

Infection

Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC₅₀ values of 34 pM against GT1a and 4 pM against GT1b replicon.

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31

Ledipasvir

31 Cited Publications

Cat. No.: HY-15602

CAS No.: 1256388-51-8

Purity: 99.69%

Synonyms: GS-5885

Target:

HCV SARS-CoV

Research Areas:

Infection

Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC₅₀s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 1.62 μM .

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30

Grazoprevir

30 Cited Publications

Cat. No.: HY-15298

CAS No.: 1350514-68-9

Purity: 99.99%

Synonyms: MK-5172

Target:

HCV Protease HCV SARS-CoV

Research Areas:

Infection

Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir inhibits SARS-CoV-2 3CL ^pro activity .

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30

Grazoprevir potassium salt

30 Cited Publications

Cat. No.: HY-15298A

CAS No.: 1206524-86-8

Purity: 99.63%

Synonyms: MK-5172 potassium salt

Target:

HCV HCV Protease SARS-CoV

Research Areas:

Infection

Grazoprevir potassium salt (MK-5172 potassium salt) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir potassium salt inhibits SARS-CoV-2 3CL ^pro activity .

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30

Grazoprevir hydrate

30 Cited Publications

Cat. No.: HY-15298B

CAS No.: 1350462-55-3

Purity: 99.99%

Synonyms: MK-5172 hydrate

Target:

HCV HCV Protease SARS-CoV

Research Areas:

Infection

Grazoprevir hydrate (MK-5172 hydrate) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir hydrate inhibits SARS-CoV-2 3CL ^pro activity .

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22

NGI-1

22 Cited Publications

Cat. No.: HY-117383

CAS No.: 790702-57-7

Purity: 99.97%

Synonyms: ML414

Target:

Virus Protease

Research Areas:

Cancer

NGI-1 (ML414) is a potent oligosaccharyltransferase (OST) inhibitor, directly targeting and blocking the function of the OST catalytic subunits STT3A and STT3B . NGI-1 is a cell permeable inhibitor and can effectively reduce virus infectivity without affecting cell viability .

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22

Estradiol benzoate

22 Cited Publications

Cat. No.: HY-B1192

CAS No.: 50-50-0

Synonyms: β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate

Category:

Disease Research Fields Cancer

Target:

Estrogen Receptor/ERR HBV Bcl-2 Family

Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice .

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20

Lamivudine

20 Cited Publications

Cat. No.: HY-B0250

CAS No.: 134678-17-4

Synonyms: BCH-189

Target:

HIV Reverse Transcriptase HBV

Research Areas:

Infection Cancer

Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .

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