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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
BCRP/ABCG2
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "BCRP/ABCG2" in MCE Product Catalog:
55
55 Cited Publications
Ko 143 is a potent and selective ATP-binding cassette subfamily G member 2 (ABCG2/BCRP) inhibitor. Ko 143 displays >200-fold selectivity over P-gp and MRP-1 transporters .
2
2 Cited Publications
YHO-13177, a acrylonitrile derivative, is an orally active, potent and specific inhibitor of breast cancer resistance protein (BCRP) and ABCG2 with an IC50 value of 10 nM. YHO-13177 potentiates the cytotoxicity of SN-38 in HCT116 and A549 cells that express BCRP. YHO-13177 combined with Irinotecan (HY-16562) significantly suppresses the tumor growth in an HCT116/BCRP xenograft model .
YHO-13351 is an orally active ABCG2 inhibitor . YHO-13351 modulates the function of ABCG2, blocks BCRP-mediated compound efflux, downregulates the expression of breast cancer resistance protein at the post-transcriptional level, and reverses ABCG2-associated tolerance. YHO-13351 restores the toxicity of SN-38 to SN-38-resistant cancer cells and sensitizes cancer cells to Irinotecan. YHO-13351 is a water-soluble prodrug that is rapidly converted to YHO-13177 (HY-12757) in mice. YHO-13351 prolongs the median survival time of mice bearing cancer cell xenografts when combined with IMMU-132. YHO-13351 extends the survival time of tumor-bearing mice and inhibits the growth of xenograft tumors when combined with Irinotecan. YHO-13351 can be used for the research of breast cancer, gastric cancer, BCRP-mediated drug-resistant cancers, and cervical cancer .
Cat. No.: HY-149469
CAS No.: 19056-75-8
Target:
Cat. No.: HY-168572
CAS No.: 2944457-11-6
MZ82, Ko 143 (HY-10010) derivative, is a ATP-binding cassette subfamily G member 2 (ABCG2/BCRP) inhibitor with the IC50 of ~23 nM. MZ82 not only shows greatly improved metabolic stability over Ko 143 (HY-10010) in liver microsomes but also in mice, and is able to penetrate into the brain .
Cat. No.: HY-W082856A
CAS No.: 155048-06-9
Butein tetramethyl ether (Compound 20) is a potent and selective breast cancer resistance protein/ATP-binding cassette subfamily G member 2 (BCRP/ABCG2) inhibitor. Butein tetramethyl ether has inhibitory potencies against MCF-7 MX and MDCK BCRP cells with IC50 values of 2.2 and 1.03 μM, respectively. Butein tetramethyl ether is promising for research of cancers .
Cat. No.: HY-122416
CAS No.: 68236-11-3
Synonyms: Lonchocarpol A; Senegalensin
Cat. No.: HY-P703266
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ABCG2; CDw338; ATP Binding Cassette Subfamily G Member 2 (JR Blood Group); Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 Isoform 1 (Junior Blood Group); BCRP; ATPbinding Cassette Transporter ABCG2; ABCP; ATP-Binding Cassette Transport
Species:
Human
Source:
HEK293
Cat. No.: HY-P703267
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ABCG2; CDw338; ATP Binding Cassette Subfamily G Member 2 (JR Blood Group); Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 Isoform 1 (Junior Blood Group); BCRP; ATPbinding Cassette Transporter ABCG2; ABCP; ATP-Binding Cassette Transport
Species:
Human
Source:
HEK293
Cat. No.: HY-P84881
Synonyms: CD338; ABCP; BCRP; BCRP1; MXR; ABCG2; Broad substrate specificity ATP-binding cassette transporter ABCG2; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporter
Cat. No.: HY-P87841
Synonyms: CD338; ABCP; BCRP; BCRP1; MXR; ABCG2; Broad substrate specificity ATP-binding cassette transporter ABCG2; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporter
Cat. No.: HY-P84881A
Synonyms: CD338; ABCP; BCRP; BCRP1; MXR; ABCG2; Broad substrate specificity ATP-binding cassette transporter ABCG2; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporter
Cat. No.: HY-10010R
CAS No.: 461054-93-3
Target:
Research Areas:
Ko 143 (Standard) is the analytical standard of Ko 143 (HY-10010). This product is intended for research and analytical applications. Ko 143 is a potent and selective ATP-binding cassette subfamily G member 2 (ABCG2/BCRP) inhibitor. Ko 143 displays >200-fold selectivity over P-gp and MRP-1 transporters .
Pentamethoxymorin (MRS923) is a selective breast cancer resistance protein (BCRP/ABCG2) inhibitor. Pentamethoxymorin shows selectivity for BCRP over P-gp and MRP1. Pentamethoxymorin inhibits MDCK BCRP cells with IC50 vaues of 5.98 μM and 5.94 μM in Hoechst 33342 (HY-15559) assay and Pheophorbide A (HY-125665) assay, respectively. Pentamethoxymorin can be used for the study of ccancer .
Cat. No.: HY-189363
Target:
Research Areas:
P-gp/BCRP-IN-3 is a dual-target inhibitor that acts on P-gp (ABCB1) and BCRP (ABCG2) transporters. P-gp/BCRP-IN-3 directly binds to both transporters, blocks efflux function without affecting protein expression, and restores intracellular accumulation of chemotherapeutic substrates. P-gp/BCRP-IN-3 enhances tumor accumulation and antitumor activity of Mitoxantrone (HY-13502) in colorectal cancer xenograft models. P-gp/BCRP-IN-3 is applicable for cancer-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
