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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
BDL
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "BDL" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-W747072
CAS No.: 71781-33-4
Synonyms: 3-Sulfocholyl Taurine; TCA3S
Target:
Research Areas:
3-Sulfo-taurocholic Acid Disodium Salt (3-Sulfocholyl Taurine; TCA3S) is a metabolite of the conjugated bile acid taurocholic acid. Plasma levels of 3-Sulfo-taurocholic Acid Disodium Salt are elevated in wild-type and Sortilin 1 (Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and are further elevated in Sort1 knockout mice at 24 hours post-BDL.
Cat. No.: HY-161506
CAS No.: 3027833-49-1
Target:
Research Areas:
PDE1-IN-7 (Compound 13h) is a selective inhibitor of bPDE1 (IC50= 10 nM). PDE1-IN-7 exhibits significant anti-fibrotic effects in a BDL-induced liver fibrosis rat model. PDE1-IN-7 can be used for research in liver fibrosis .
Cat. No.: HY-D3525
Target:
Research Areas:
BDL-E5 is a fluorescent probe for detecting live induced pluripotent stem cells at the early reprogramming stage. Its detection mechanism involves specific binding to authentic reprogramming cells, which exhibit increased expression of pluripotency and epithelial genes and decreased expression of mesenchymal genes compared to non-reprogramming cells; it appears to co-localize more significantly with the Golgi complex than other organelle markers in reprogramming cells, and it does not require washing after staining to reduce background signals; fluorescence is generated upon binding to these early reprogramming cells, with positive cells appearing 7 days before iPS colonies are visible and stain positive for the conventional pluripotent marker TRA-1-60, and sorting BDL-E5-positive cells enriches populations that generate higher numbers and quality of iPS colonies. Its detection wavelength is Ex/Em = 578/599 nm .
Cat. No.: HY-181655
CAS No.: 3127060-85-6
Target:
Research Areas:
Anti-hepatic fibrosis agent 3 is an orally active anti-hepatic fibrosis compound targeting Cathepsin D. Anti-hepatic fibrosis agent 3 shows an IC50 of 53.18 μM against COL1A1-promoter and a Kd of 8.86 μM for binding to Cathepsin D. Anti-hepatic fibrosis agent 3 directly binds to and promotes the degradation of Cathepsin D, with no significant effect on Cathepsin B or Cathepsin L. Anti-hepatic fibrosis agent 3 inhibits hepatic stellate cell activation and reduces extracellular matrix deposition and inflammatory cytokine expression. Anti-hepatic fibrosis agent 3 exhibits remarkable anti-fibrotic activity in rat BDL and mouse CDAHFD-induced hepatic fibrosis models. Anti-hepatic fibrosis agent 3 can be used for the study of hepatic fibrosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
