22 Results for "

BIR3

" in MedChemExpress (MCE) Product Catalog:
Products (22)

22 Results for "BIR3" in MCE Product Catalog:

61
SM-164
SM-164
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61 Publications Verification
Cat. No.: HY-15989
CAS No.: 957135-43-2
Target:  

IAP Apoptosis

Research Areas:  

Cancer

SM-164 is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains with an IC50 value of 1.39 nM and functions as an extremely potent antagonist of XIAP.
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61
SM-164 hydrochloride
SM-164 hydrochloride
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61 Publications Verification
Cat. No.: HY-15989A
CAS No.: 2734174-02-6
Target:  

IAP Apoptosis

Research Areas:  

Cancer

SM-164 hydrochloride is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains with an IC50 value of 1.39 nM and functions as an extremely potent antagonist of XIAP.
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18
AZD5582
AZD5582
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18 Cited Publications
Cat. No.: HY-12600
CAS No.: 1258392-53-8
Purity:  98.75%
Target:  

IAP Apoptosis

Research Areas:  

Cancer

AZD5582 is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis .
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18
AZD5582 dihydrochloride
AZD5582 dihydrochloride
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18 Cited Publications
Cat. No.: HY-110346
CAS No.: 1883545-51-4
Target:  

IAP Apoptosis

Research Areas:  

Cancer

AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis .
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14
GDC-0152
GDC-0152
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14 Cited Publications
Cat. No.: HY-13638
CAS No.: 873652-48-3
Purity:  99.70%
Target:  

IAP

Research Areas:  

Cancer

GDC-0152 is a potent IAPs inhibitor, and binds to the BIR3 domains of XIAP, cIAP1, cIAP2 and the BIR domain of ML-IAP with Ki values of 28 nM, 17 nM, 43 nM and 14 nM, respectively.
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13
Xevinapant hydrochloride
Xevinapant hydrochloride
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13 Cited Publications
Cat. No.: HY-13208
CAS No.: 1071992-57-8
Purity:  98.01%
Synonyms: AT-406 hydrochloride; Debio 1143 hydrochloride; SM-406 hydrochloride
Target:  

IAP Apoptosis

Research Areas:  

Cancer

Xevinapant (AT-406) hydrochloride is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs). Xevinapant hydrochloride binds to XIAP, cIAP1, and cIAP2 proteins with Kis of 66.4, 1.9, and 5.1 nM, respectively. Xevinapant hydrochloride effectively antagonizes XIAP BIR3 protein in a cell-free functional assay, induces rapid degradation of cellular cIAP1 protein, and inhibits cancer cell growth in various human cancer cell lines. Xevinapant hydrochloride is highly effective in induction of apoptosis in xenograft tumors .
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Fmoc-N-Me-Ala-OH
Fmoc-N-Me-Ala-OH
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Cat. No.: HY-W008235
CAS No.: 84000-07-7
Target:  

Amino Acid Derivatives Drug Intermediate

Research Areas:  

Cancer

Fmoc-N-Me-Ala-OH is an Fmoc-protected N-methyl-L-alanine and also a building block for solid-phase peptide synthesis. As a building block, Fmoc-N-Me-Ala-OH is used to synthesize peptidomimetic antagonists of XIAP BIR3 derived from Smac/DIABLO [3].
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SM-1295
SM-1295
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Cat. No.: HY-124181
CAS No.: 1562375-46-5
Purity:  98.71%
Target:  

IAP Apoptosis

Research Areas:  

Cancer

SM-1295 is an inhibitor of apoptosis protein (IAP) antagonist, with Kd values of 3077 nM, 3.2 nM and 9.5 nM for XIAP-BIR3, c-IAP1-BIR3 and c-IAP2-BIR3, respectively .
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Sanggenon G
Sanggenon G
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Cat. No.: HY-12372
CAS No.: 85698-31-3
Purity:  97.23%
Category:  

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