24 Results for "

BMI1

" in MedChemExpress (MCE) Product Catalog:
Products (24)

24 Results for "BMI1" in MCE Product Catalog:

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16
PTC-209
PTC-209
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16 Publications Verification
Cat. No.: HY-15888
CAS No.: 315704-66-6
Purity:  99.76%
Target:  

BMI1 Autophagy

Research Areas:  

Cancer

PTC-209 is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 shows potent anti-myeloma activity and impairs the tumor microenvironment [1] .
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16
PTC-209 hydrobromide
PTC-209 hydrobromide
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16 Publications Verification
Cat. No.: HY-15888A
CAS No.: 1217022-63-3
Purity:  99.44%
Target:  

BMI1 Autophagy

Research Areas:  

Cancer

PTC-209 hydrobromide is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 hydrobromide irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 hydrobromide shows potent anti-myeloma activity and impairs the tumor microenvironment [1] .
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3
Unesbulin
Unesbulin
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3 Cited Publications
Cat. No.: HY-112041
CAS No.: 1610964-64-1
Purity:  99.45%
Synonyms: PTC596
Target:  

BMI1 Apoptosis

Research Areas:  

Cancer

Unesbulin (PTC596) is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. Unesbulin downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia (AML) cells. Unesbulin has anti-leukemic activity [1] .
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3
PTC-028
PTC-028
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3 Cited Publications
Cat. No.: HY-103696
CAS No.: 1782970-28-8
Purity:  ≥98.0%
Target:  

BMI1 Apoptosis

Research Areas:  

Cancer

PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. PTC-028 selectively inhibits cancer cells whereas normal cells remain unaffected. PTC-028 downregulates BMI-1, inducing caspase-mediated apoptosis [1].
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1
BMI1 Protein, Human (His)
BMI1 Protein, Human (His)
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1 Cited Publications
Cat. No.: HY-P701224
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BMI1; BMI1 Polycomb Ring Finger Proto-Oncogene; Prev. PCGF4; Polycomb Group Ring Finger 4; RNF51; Polycomb Group Protein BMI1; Polycomb Group RING Finger Protein 4; Ring Finger Protein 51; Polycomb Complex Protein BMI-1; RING Finger Protein 51; B Lymphoma
Species:  
Human
Source:  
E. coli
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1
Bmi-1 Antibody (YA821)
Bmi-1 Antibody (YA821)
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1 Cited Publications
Cat. No.: HY-P80034
Synonyms: PCGF4, RNF51, BMI1, Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, RING finger protein 51

Host:  

Mouse

Application:  

WB, ICC/IF, IHC-P, FC

Reactivity:  

Human, Mouse, Rat

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RB-3
RB-3
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Cat. No.: HY-139514
CAS No.: 2396639-11-3
Purity:  99.42%
Target:  

E1/E2/E3 Enzyme

Research Areas:  

Cancer

RB-3, a polycomb repressive complex 1 (PRC1) inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM [1].
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MS147
MS147
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Cat. No.: HY-160924
Target:  

PROTACs BMI1 E1/E2/E3 Enzyme Histone Methyltransferase

Research Areas:  

Cancer

MS147 is a VHL-based PROTAC degrader of BMI1 and RING1B (polycomb repressive complex 1 core components). MS147 directly binds EED and VHL E3 ligase, recruiting the ligase to the EED-BMI1/RING1B complex to induce time-dependent, ubiquitination-mediated degradation of BMI1 and RING1B. MS147 reduces histone H2A Lys119 mono-ubiquitination without altering histone H3 Lys27 tri-methylation and inhibits cancer cells proliferation. MS147 can be used for the research of cancer, such as chronic myelogenous leukemia and b-cell lymphoma [1].
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PRC1-IN-1
PRC1-IN-1
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Cat. No.: HY-170823
CAS No.: 2396639-29-3
Target:  

E1/E2/E3 Enzyme

Research Areas:  

Cancer

PRC1-IN-1 is a PRC1 complex inhibitor. PRC1-IN-1 binds to both RING1A and RING1B proteins, and inhibits the activities of RING1B-BMI1 and RING1B-PCGF1. PRC1-IN-1 effectively inhibits H2AK119 ubiquitination and induces cell differentiation in leukemia cells. PRC1-IN-1 can be used for the research of leukemia [1].
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MS181
MS181
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Cat. No.: HY-158239
CAS No.: 3037165-65-1
Purity:  98.36%
Target:  

PROTACs BMI1 E1/E2/E3 Enzyme HOXA

Research Areas:  

Cancer

MS181 is a BMI1 and RING1B degrader with antiproliferative activity. MS181 induces degradation via an EED-, CRBN-, and ubiquitin-proteosome system-dependent pathway, with preferential targeting over PRC2 components. MS181 acts in VHL-defective cancer cells. MS181 serves as a chemical biology tool to study PRC1 roles in cancer. MS181 can be used for the research of myelogenous leukemia, renal cell carcinoma, metastatic prostate cancer, triple negative breast cancer [1].
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Bmi1 Mouse Pre-designed siRNA Set A
Bmi1 Mouse Pre-designed siRNA Set A
Cat. No.: HY-RS18603
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

Bmi1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bmi1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BMI1 Human Pre-designed siRNA Set A
BMI1 Human Pre-designed siRNA Set A
Cat. No.: HY-RS01532
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

BMI1 Human Pre-designed siRNA Set A contains three designed siRNAs for BMI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Bmi1 Rat Pre-designed siRNA Set A
Bmi1 Rat Pre-designed siRNA Set A
Cat. No.: HY-RS25088
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

Bmi1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bmi1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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QW24
QW24
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Cat. No.: HY-143655
CAS No.: 2416312-06-4
Target:  

BMI1 Autophagy

Research Areas:  

Cancer

QW24 exerts potent anti-tumor activity by down-regulating BMI-1 and is used as an effective therapeutic agent for clinical colorectal cancer research.
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BMI1/RING1B ligand-1
BMI1/RING1B ligand-1
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Cat. No.: HY-183634
Target:  

Ligands for Target Protein for PROTAC BMI1 E1/E2/E3 Enzyme

Research Areas:  

Others

BMI1/RING1B ligand-1 is a BMI1/RING1B ligand. BMI1/RING1B ligand-1 can be used to synthesize PROTAC S147 (HY-160924).
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APD-94
APD-94
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Cat. No.: HY-172617
CAS No.: 877810-03-2
Target:  

BMI1 Microtubule/Tubulin Apoptosis

Research Areas:  

Cancer

APD-94 is a dual inhibitor targeting tubulin and Bmi-1. APD-94 interfers tubulin normal polymerization. APD-94 suppresses the expression of Bmi-1. APD-94 causes cell cycle arrest at the G2/M phase in cancer cells and induces apoptosis, thus inhibiting cancer cell proliferation. APD-94 represses the growth of HT29 cell xenografts in NOD/SCID mice. APD-94 can be used for colorectal cancer study [1].
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1,6,7-Trihydroxyxanthone
1,6,7-Trihydroxyxanthone
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Cat. No.: HY-N0992
CAS No.: 25577-04-2
Category:  

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