78

Oseltamivir acid

78 Publications Verification

Cat. No.: HY-13318

CAS No.: 187227-45-8

Purity: 99.50%

Synonyms: GS 4071; Ro 64-0802; Oseltamivir carboxylate

Target:

Influenza Virus Drug Metabolite

Research Areas:

Infection Neurological Disease

Oseltamivir acid (GS 4071), the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC₅₀=2 nM) with activity against both influenza A and B viruses. Oseltamivir acid has an extremely weak ability to penetrate the BBB under normal physiological conditions, but its blood-brain barrier penetration is significantly enhanced under inflammatory conditions .

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16

A-967079

16 Cited Publications

Cat. No.: HY-108463

CAS No.: 1170613-55-4

Purity: 99.30%

Target:

TRP Channel

Research Areas:

Neurological Disease Inflammation/Immunology

A-967079 is a selective TRPA1 receptor antagonist with IC₅₀s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and has good penetration into the blood-brain barrier .

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7

2-PMPA

7 Cited Publications

Cat. No.: HY-100788

CAS No.: 173039-10-6

Purity: ≥98.0%

Synonyms: 2-(Phosphonomethyl)pentanedioic acid

Target:

Carboxypeptidase

Research Areas:

Neurological Disease

2-PMPA (2-(Phosphonomethyl)pentanedioic acid) is a glutamate carboxypeptidase II (GCPII) inhibitor with an IC₅₀ of 0.0003 μM. 2-PMPA shows low blood-brain barrier penetration. 2-PMPA sodium blocks the hydrolysis of NAAG, regulates glutamate levels in the brain and neurovascular coupling. 2-PMPA is applicable to the research of neurological diseases .

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7

URMC-099

7 Cited Publications

Cat. No.: HY-12599

CAS No.: 1229582-33-5

Purity: 99.34%

Target:

Mixed Lineage Kinase Autophagy

Research Areas:

Neurological Disease Cancer

URMC-099 is an orally bioavailable and potent mixed lineage kinase type 3 (MLK3) (IC₅₀=14 nM) inhibitor with with excellent blood-brain barrier penetration properties.

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7

2-PMPA sodium

7 Cited Publications

Cat. No.: HY-100788C

CAS No.: 373645-42-2

Synonyms: 2-(Phosphonomethyl)pentanedioic acid sodium

Target:

Carboxypeptidase

Research Areas:

Neurological Disease

2-PMPA (2-(Phosphonomethyl)pentanedioic acid) sodium is a glutamate carboxypeptidase II (GCPII) inhibitor with an IC₅₀ of 0.0003 μM. 2-PMPA sodium shows low blood-brain barrier penetration. 2-PMPA sodium blocks the hydrolysis of NAAG, regulates glutamate levels in the brain and neurovascular coupling. 2-PMPA sodium is applicable to the research of neurological diseases .

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5

Decanoic acid sodium

5 Cited Publications

Cat. No.: HY-115340

CAS No.: 1002-62-6

Purity: 99.92%

Synonyms: Sodium decanoate; Sodium caprate

Decanoic acid sodium, also known as Decanoic acid sodium, is a salt of the fatty acid capric acid. It is easily soluble in water and has a slightly soapy smell. Decanoic acid sodium acts as a penetration enhancer, which means it increases the absorption and bioavailability of drugs across biological membranes, including the intestinal epithelium and the blood-brain barrier. This property makes it useful in pharmaceutical formulations to improve drug delivery and effectiveness. Furthermore, Decanoic acid sodium has potential applications in food preservatives and cosmetics due to its antibacterial properties.

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5

Pirenzepine dihydrochloride

5 Cited Publications

Cat. No.: HY-17037

CAS No.: 29868-97-1

Synonyms: LS 519; Pirenzepin dihydrochloride; Gastrozepin dihydrochloride

Target:

mAChR

Research Areas:

Metabolic Disease Cancer

Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist, with poor penetration of the blood-brain barrier. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells .

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5

Pirenzepine

5 Cited Publications

Cat. No.: HY-17037A

CAS No.: 28797-61-7

Synonyms: LS 519 free base; Pirenzepin; Gastrozepin

Target:

mAChR

Research Areas:

Metabolic Disease Cancer

Pirenzepine (LS 519 free base) is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist, with poor penetration of the blood-brain barrier. Pirenzepine reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine shows anti-proliferative activity to cancer cells .

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3

Metopimazine

3 Cited Publications

Cat. No.: HY-116578

CAS No.: 14008-44-7

Purity: 98.03%

Synonyms: EXP999; RP9965

Target:

Dopamine Receptor

Research Areas:

Neurological Disease

Metopimazine (EXP999; RP9965) is a phenothiazine, orally available, selective dopamine D2 receptor antagonist that does not penetrate the blood-brain barrier. Metopimazine blocks dopamine D2 receptors in the chemoreceptor trigger zone and the periphery, thereby inhibiting nausea and vomiting. Metopimazine is indicated for chemotherapy-induced nausea and vomiting, and has low central side effects due to its poor brain penetration. The use of metopimazine in acute gastroenteritis may have potential risks .

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2

LDN-214117

2 Cited Publications

Cat. No.: HY-16712

CAS No.: 1627503-67-6

Target:

TGF-β Receptor

Research Areas:

Cancer

LDN-214117 is an orally active ALK2 inhibitor with well-tolerated and good brain penetration. LDN-214117 has a high selectivity and low cytotoxicity for ALK2 with an IC₅₀ value of 24 nM. LDN-214117 also is a specific bone morphogenetic proteins (BMPs) signaling inhibitor and has relatively selective inhibition for BMP6 with an IC₅₀ value of 100 nM. LDN-214117 can be used for the research of fibrodysplasia ossificans progressiva (FOP), diffuse intrinsic pontine glioma (DIPG) .

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2

Hordenine

2 Cited Publications

Cat. No.: HY-N0113

CAS No.: 539-15-1

Synonyms: Ordenina; Peyocactine

Category:

Cardiovascular Disease Alkaloids Monophenols Other Alkaloids Phenols Plants Other Families Extract Disease Research Fields

Target:

Bacterial p38 MAPK JNK ERK Akt Interleukin Related TNF Receptor NO Synthase COX Reactive Oxygen Species (ROS) Microphthalmia Associated Transcription Factor (MITF) Wnt β-catenin Dopamine Receptor Adrenergic Receptor 5-HT Receptor Serotonin Transporter Dopamine Transporter α-synuclein

Hordenine (Ordenina; Peyocactine) is a multifunctional alkaloid with oral activity and blood-brain barrier penetration. Hordenine inhibits LPS-induced phosphorylation of p38, JNK, ERK1/2, p65, IκB, and AKT, prevents p65 nuclear translocation, and suppresses inflammatory cytokines and mediators. Hordenine promotes M2 macrophage polarization, restores blood-milk barrier integrity, alleviates oxidative stress by reducing ROS and MDA, and attenuates LPS-induced lung injury and pulmonary edema. Hordenine inhibits cAMP production, CREB phosphorylation, and MITF expression, thereby suppressing melanin synthesis in melanocytes and reconstructed epidermis. Hordenine activates the Wnt/β-catenin signaling pathway, promotes dermal papilla cell proliferation and hair shaft elongation, and accelerates hair regeneration. Hordenine activates DRD2, acts as a D3R partial agonist, α2A-AR full agonist, and 5-HT2A-R antagonist, and inhibits SERT and DAT. Hordenine inhibits α-synuclein accumulation and ameliorates motor deficits in Parkinson's disease models. Hordenine limits alcohol intake, reduces relapse drinking behavior, and modulates alcohol-induced conditioned place preference. Hordenine can be used for research on mastitis, skin pigmentation, acute lung injury, foodborne diseases, hair loss, Parkinson's disease, bacterial infections, and alcohol use disorder .

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