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60 Results for "

C pockets

" in MedChemExpress (MCE) Product Catalog:

Products (60)

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Apcin

11 Publications Verification

Cat. No.: HY-110287

CAS No.: 300815-04-7

Purity: 99.62%

Target:

APC Mitosis

Research Areas:

Cancer

Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis .

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Divarasib

6 Cited Publications

Cat. No.: HY-145928

CAS No.: 2417987-45-0

Purity: 99.31%

Synonyms: GDC-6036

Target:

Ras

Research Areas:

Cancer

Divarasib (GDC-6036) is an orally active, selective KRAS ^G12C inhibitor with an IC₅₀ of <0.01 μM. Divarasib covalently binds Cys12 in GDP-bound KRAS ^G12C, occupies the switch II pocket, blocks GTP binding and SOS-mediated reactivation, and inhibits oncogenic KRAS signaling. Divarasib induces tumor shrinkage and robust tumor growth inhibition in KRAS ^G12C-positive models and cancer cells. Divarasib can be used for the research of non-small cell lung cancer, colorectal adenocarcinoma, pancreatic ductal adenocarcinoma, and other KRAS ^G12C-mutated solid tumors .

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Divarasib adipate

6 Cited Publications

Cat. No.: HY-145928B

CAS No.: 2762240-36-6

Synonyms: GDC-6036 adipate

Target:

Ras

Research Areas:

Cancer

Divarasib (GDC-6036) adipate is an orally active, selective KRASG12C inhibitor with an IC50 of <0.01 μM. Divarasib adipate covalently binds Cys12 in GDP-bound KRASG12C, occupies the switch II pocket, blocks GTP binding and SOS-mediated reactivation, and inhibits oncogenic KRAS signaling. Divarasib adipate induces tumor shrinkage and robust tumor growth inhibition in KRASG12C-positive models and cancer cells. Divarasib adipate can be used for the research of non-small cell lung cancer, colorectal adenocarcinoma, pancreatic ductal adenocarcinoma, and other KRASG12C-mutated solid tumors .

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Rezatapopt

4 Cited Publications

Cat. No.: HY-156633

CAS No.: 2636846-41-6

Purity: 99.78%

Synonyms: PC14586

Target:

MDM-2/p53

Research Areas:

Cancer

Rezatapopt (PC14586) is an orally active antineoplastic agent. Rezatapopt binds to a pocket created by the TP53 Y220C mutation. Rezatapopt restores p53 tumor suppressor functions by stabilization of the p53 protein structure. Rezatapopt demonstrates tumor inhibition and regression in mouse models with established human tumor xenografts harboring the TP53 Y220C mutation .

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