1015 Results for "

C-C

" in MedChemExpress (MCE) Product Catalog:

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132

C-176

132 Publications Verification

Cat. No.: HY-112906

CAS No.: 314054-00-7

Purity: 99.45%

Target:

STING

Research Areas:

Inflammation/Immunology

C-176 is a selective and blood-brain barrier permeable STING inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING .

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Lenalidomide

64 Cited Publications

Cat. No.: HY-A0003

CAS No.: 191732-72-6

Synonyms: CC-5013

Target:

Molecular Glues Ligands for E3 Ligase IKZF Family Casein Kinase Apoptosis Pyroptosis MDM-2/p53 TNF Receptor

Research Areas:

Cardiovascular Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer

Lenalidomide (CC-5013) is an orally active immunomodulatory agent that binds CRBN as a molecular glue to alter substrate specificity, inducing ubiquitination and proteasome-dependent degradation of IKZF1, IKZF3 and CK1α. Lenalidomide induces apoptosis by degrading IKZF1/3, and activates p53 by degrading CK1α. Lenalidomide promotes IL-2 release and effector functions of CD8 ⁺ T/NK cells, while inhibiting TNF-α secretion and M1-type pyroptosis. Lenalidomide can be used in research related to hematological malignancies, acute liver failure and acute kidney injury .

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Lenalidomide hemihydrate

64 Cited Publications

Cat. No.: HY-A0003B

CAS No.: 847871-99-2

Synonyms: CC-5013 hemihydrate

Target:

Molecular Glues Ligands for E3 Ligase IKZF Family Casein Kinase Apoptosis Pyroptosis MDM-2/p53 TNF Receptor

Lenalidomide hemihydrate (CC-5013 hemihydrate) is an orally active immunomodulatory agent that binds CRBN as a molecular glue to alter substrate specificity, inducing ubiquitination and proteasome-dependent degradation of IKZF1, IKZF3 and CK1α. Lenalidomide hemihydrate induces apoptosis by degrading IKZF1/3, and activates p53 by degrading CK1α. Lenalidomide hemihydrate promotes IL-2 release and effector functions of CD8 ⁺ T/NK cells, while inhibiting TNF-α secretion and M1-type pyroptosis. Lenalidomide hemihydrate can be used in research related to hematological malignancies, acute liver failure and acute kidney injury .

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Auranofin

48 Cited Publications

Cat. No.: HY-B1123

CAS No.: 34031-32-8

Synonyms: SKF-39162

Target:

Bacterial SARS-CoV

Research Areas:

Infection Inflammation/Immunology Cancer

Auranofin (SKF-39162) is a thioredoxin reductase (TrxR) inhibitor with an IC₅₀ of 0.2 μM. Auranofin exhibits antiviral activity against SARS-CoV21, with a CC₅₀ of 4.2 μM for monkey kidney Vero E6 cells.

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Pomalidomide

39 Cited Publications

Cat. No.: HY-10984

CAS No.: 19171-19-8

Purity: 99.88%

Synonyms: CC-4047; Actimid

Target:

Ligands for E3 Ligase Molecular Glues Apoptosis IKZF Family

Research Areas:

Cancer

Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.

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C188-9

38 Cited Publications

Cat. No.: HY-112288

CAS No.: 432001-19-9

Purity: 99.90%

Synonyms: TTI-101

Target:

STAT Apoptosis DNA Methyltransferase

Research Areas:

Metabolic Disease Inflammation/Immunology Cancer

C188-9 (TTI-101) is a STAT3 inhibitor with a K_d value of 4.7 nM. C188-9 targets the SH2 domain of STAT3, blocks the processes of STAT3 ligand binding, receptor recruitment, homodimerization and phosphorylation, and regulates STAT3-mediated genes associated with tumorigenesis and radioresistance. C188-9 regulates STAT1-mediated genes related to radioresistance and reduces the activation level of STAT1. C188-9 downregulates the expression of DNMT1, enhances DAC-induced demethylation and re-expression of RASSF1A, and simultaneously potentiates the anti-tumor effect of DAC on pancreatic cancer cells. C188-9 inhibits both anchorage-dependent and anchorage-independent growth of cancer cells, induces Apoptosis, blocks the growth of tumor xenografts, and suppresses muscle atrophy. C188-9 maintains muscle mass, increases body weight and improves grip strength in tumor-bearing mice. C188-9 can be used in research related to head and neck squamous cell carcinoma, pancreatic cancer, sepsis-related skeletal muscle wasting, non-small cell lung cancer, acute myeloid leukemia and cancer cachexia .

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