134

Elesclomol

134 Publications Verification

Cat. No.: HY-12040

CAS No.: 488832-69-5

Purity: 99.80%

Synonyms: STA-4783

Target:

Reactive Oxygen Species (ROS) Apoptosis Cuproptosis

Research Areas:

Cancer

Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research .

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71

Zinc Protoporphyrin

71 Cited Publications

Cat. No.: HY-101193

CAS No.: 15442-64-5

Purity: 99.87%

Synonyms: Zn(II)-protoporphyrin IX; ZnPP; Zinc Protoporphyrin-9

Category:

Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Cancer

Target:

Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis

Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor. Zinc Protoporphyrin regulates expression of HO-1 at the transcriptional level. The effect of Zinc Protoporphyrin on HO-1 expression is controversial. It was shown to induce HO-1 expression in some cells, but suppress it in others. Zinc Protoporphyrin is used as a screening marker of iron deficiency in vivo. Zinc Protoporphyrin has anti-cancer activity .

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31

Folic acid

31 Cited Publications

Cat. No.: HY-16637

CAS No.: 59-30-3

Synonyms: Vitamin B9; Vitamin M

Category:

Neurological Disease Anti-aging Endocrine diseases Plants Other Families Extract Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Disease Research Fields Cancer

Target:

Environmental Pollutants Endogenous Metabolite DNA/RNA Synthesis

Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency .

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31

Folic acid disodium

31 Cited Publications

Cat. No.: HY-16637D

CAS No.: 29704-76-5

Synonyms: Vitamin B9 disodium; Vitamin M disodium

Category:

Natural Products Neurological Disease Endogenous metabolite Disease Research Fields Cancer

Target:

Endogenous Metabolite DNA/RNA Synthesis

Folic acid disodium (Vitamin B9 disodium; Vitamin M disodium) is an orally active disodium salt form of Folic acid (HY-16637) with an intrinsic dissolution rate (IDR) of 4.96·10 ⁵ g/s . Folic acid disodium serves as cofactor in single-carbon transfer reactions and exhibits protective effects against neural tube defects, ischemic events, and cancer. Folate acid disodium overload leads to impaired brain development in embryogenesis and promotes growth of precancerous altered cells. Folic acid deficiency leads to megaloblastic anemia .

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25

Saruparib

25 Cited Publications

Cat. No.: HY-132167

CAS No.: 2589531-76-8

Purity: 99.76%

Synonyms: AZD5305

Target:

PARP

Research Areas:

Cancer

Saruparib (AZD5305) is a potent, orally active and selective PARP inhibitor and trapper with IC₅₀ values of 3 nM and 1400 nM for PARP1 and PARP2, respectively. Saruparib has anti-proliferative activity and inhibits growth in cells with deficiencies in DNA repair .

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14

SZL P1-41

14 Cited Publications

Cat. No.: HY-100237

CAS No.: 222716-34-9

Purity: 99.07%

Target:

E1/E2/E3 Enzyme Apoptosis

Research Areas:

Cancer

SZL P1-41 is a specific Skp2 inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. SZL P1-41, like Skp2 deficiency, augments p27-mediated apoptosis/senescence, while it impairs Akt-driven glycolysis. Anti-tumor activities .

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8

QX77

8 Cited Publications

Cat. No.: HY-112483

CAS No.: 1798331-92-6

Purity: 99.48%

Target:

Autophagy

Research Areas:

Cancer

QX77 is a chaperone-mediated autophagy (CMA) activator and upregulates LAMP2A expression in vitro. QX77 induces Rab11 upregulation, rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells . QX77 can impede self-renewal and promote differentiation of ES cells .

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7

Ferric citrate

7 Cited Publications

Cat. No.: HY-N1428C

CAS No.: 3522-50-7

Synonyms: Iron(III) citrate; Zerenex

Target:

Reactive Oxygen Species (ROS) Antibiotic

Research Areas:

Metabolic Disease

Ferric citrate (Iron(III) citrate), an orally active iron supplement, is an efficacious phosphate binder. Ferric citratee can be used for iron deficiency anemia and chronic kidney disease (CKD) research .

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5

Enclomiphene

5 Cited Publications

Cat. No.: HY-118861

CAS No.: 15690-57-0

Synonyms: (E)-Clomiphene; trans-Clomiphene; Enclomifene

Target:

Estrogen Receptor/ERR

Research Areas:

Metabolic Disease Endocrinology

Enclomiphene ((E)-Clomiphene) is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes .

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5

Succinyl-Coenzyme A sodium

5 Cited Publications

Cat. No.: HY-137808

CAS No.: 108347-97-3

Purity: 94%

Synonyms: Succinyl-CoA sodium

Category:

Natural Products Neurological Disease Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

Succinyl CoA (Succinyl-coenzyme A) sodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA sodium is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA sodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA sodium insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA sodium can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .

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5

Ibutamoren

5 Cited Publications

Cat. No.: HY-10199A

CAS No.: 159634-47-6

Purity: 98.52%

Synonyms: MK-677 free base; MK-0677 free base

Target:

GHSR Insulin Receptor

Research Areas:

Neurological Disease Metabolic Disease

Ibutamoren (MK-677 free base; MK-0677 free base) is an orally active non-peptide growth hormone secretagogue receptor agonist. Ibutamoren activates signal cascades by mimicking endogenous ligands, triggers pulsatile release of growth hormone from the pituitary gland, and increases serum levels of IGF-1 and insulin-like growth factor-binding protein 3. Ibutamoren not only increases the frequency of growth hormone pulses in male individuals, but also promotes elevated bone formation markers in female individuals with postmenopausal osteoporosis. The combination of Ibutamoren with Alendronate sodium hydrate (HY-11101) significantly increases bone mineral density at the femoral neck. However, Ibutamoren may cause mild, reversible adverse reactions such as increased appetite, fluid retention, and elevated fasting blood glucose. Ibutamoren has been widely used in studies related to idiopathic growth hormone deficiency, sarcopenia, Alzheimer's disease, and osteoporosis .

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4

Methylmalonic acid

4 Cited Publications

Cat. No.: HY-103395

CAS No.: 516-05-2

Purity: ≥98.0%

Synonyms: Methylpropanedioic acid; Methylmalonate

Category:

Human Gut Microbiota Metabolites Immune System Disorder Ketones, Aldehydes, Acids Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields Cancer

Target:

Endogenous Metabolite

Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer.

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4

Mitapivat

4 Cited Publications

Cat. No.: HY-12689

CAS No.: 1260075-17-9

Purity: 99.84%

Synonyms: AG-348

Target:

Pyruvate Kinase

Research Areas:

Metabolic Disease

Mitapivat (AG-348) is an orally active pyruvate kinase allosteric activator. Mitapivat increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes, shows the potential to restore the activity of PK (pyruvate kinase)-deficient glycolytic pathways. Mitapivat can be used in study of PK deficiency .

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3

Dydrogesterone

3 Cited Publications

Cat. No.: HY-B0257A

CAS No.: 152-62-5

Target:

Progesterone Receptor

Research Areas:

Endocrinology

Dydrogesterone is a potent, orally active progestogen indicated in a wide variety of gynaecological conditions related to progesterone deficiency.

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3

Hydroxocobalamin monohydrochloride

3 Cited Publications

Cat. No.: HY-B2209A

CAS No.: 59461-30-2

Synonyms: Vitamin B12a monohydrochloride

Category:

Human Gut Microbiota Metabolites Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

Hydroxocobalamin monohydrochloride (Vitamin B12a monohydrochloride) is an injectable naturally occurring form of vitamin B12 with a favorable adverse effect profile, used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia .

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3

Hydroxocobalamin acetate

3 Cited Publications

Cat. No.: HY-B2209B

CAS No.: 22465-48-1

Synonyms: Vitamin B12a acetate

Category:

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

NO Synthase

Hydroxocobalamin acetate is an injectable natural vitamin B12. Hydroxocobalamin acetate binds to NO. Hydroxocobalamin acetate detoxifies Cyanide and NaSH. Hydroxocobalamin acetate reduces hypotension. Hydroxocobalamin acetate is used in research related to vitamin B12 deficiency, including pernicious anemia .

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3

Lalistat 2

3 Cited Publications

Cat. No.: HY-128144

CAS No.: 1234569-09-5

Purity: 99.87%

Target:

Lipase

Research Areas:

Metabolic Disease

Lalistat 2 is an inhibitor of many lipases especially Lysosomal acid lipase (LAL, IC₅₀ = 152 nM), which is a key enzyme that degrades neutral lipids at an acidic pH in lysosomes. Lalistat 2 is commonly used to investigate the cell-specific functions of LAL and LAL deficiency in vitro, as well as specifically measure LAL activity in human blood samples or cells .

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3

Hydroxocobalamin

3 Cited Publications

Cat. No.: HY-B2209

CAS No.: 13422-51-0

Synonyms: Vitamin B12a

Category:

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

Hydroxocobalamin (Vitamin B12a) is a cyanide antidote. Hydroxocobalamin can decrease the cell and plasma cyanide concentrations and increase survival rate in acute cyanide poisoning. Hydroxocobalamin can improve newborn Cbl-C defect-induced metabolic profile and neurocognitive outcome. Hydroxocobalamin can normalize Vitamin B₁₂ deficiency. Hydroxocobalamin can induce acute kidney injury. Hydroxocobalamin can be used for the researches of metabolic and neurological disease .

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