40

Rhosin hydrochloride

40 Publications Verification

Cat. No.: HY-12646

CAS No.: 1281870-42-5

Purity: 99.93%

Target:

Ras Apoptosis

Research Areas:

Cancer

Rhosin hydrochloride is a potent, specific RhoA subfamily Rho GTPases inhibitor. Rhosin hydrochloride specifically binds to RhoA to inhibit RhoA-GEF interaction with a K_d of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin hydrochloride induces cell apoptosis . Rhosin hydrochloride promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability .

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40

Rhosin

40 Publications Verification

Cat. No.: HY-12646A

CAS No.: 1173671-63-0

Purity: 95.08%

Target:

Ras Apoptosis

Research Areas:

Cancer

Rhosin is a potent, specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction with a K_d of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin induces cell apoptosis . Rhosin promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability .

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38

ML141

38 Cited Publications

Cat. No.: HY-12755

CAS No.: 71203-35-5

Purity: 99.96%

Synonyms: CID-2950007

Target:

Ras Apoptosis

Research Areas:

Cancer

ML141 (CID-2950007) is a potent, allosteric, selective and reversible non-competitive inhibitor of Cdc42 GTPase. ML141 inhibits Cdc42 wild type and Cdc42 Q61L mutant with EC₅₀s of 2.1 and 2.6 μM, respectively. ML141 shows low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 do not show cytotoxicity in multiple cell lines .

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12

CASIN

12 Cited Publications

Cat. No.: HY-12874

CAS No.: 425399-05-9

Purity: 99.89%

Target:

Ras Apoptosis

Research Areas:

Cancer

CASIN is a selective GTPase Cdc42 inhibitor with an IC₅₀ of 2 uM. CASIN can be used for the research of cancer .

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12

MBQ-167

12 Cited Publications

Cat. No.: HY-112842

CAS No.: 2097938-73-1

Purity: 99.64%

Target:

Ras CDK

Research Areas:

Cancer

MBQ-167 is a dual Rac/Cdc42 inhibitor, with IC₅₀s of 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively.

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6

N-Acetylneuraminic acid

6 Cited Publications

Cat. No.: HY-I0400

CAS No.: 131-48-6

Synonyms: NANA; Lactaminic acid

Category:

Cardiovascular Disease Endogenous metabolite Disease Research Fields Saccharides Monosaccharides

Target:

Tyrosinase Ras Influenza Virus Endogenous Metabolite

N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia .

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4

alpha-Cyperone

4 Cited Publications

Cat. No.: HY-N0710

CAS No.: 473-08-5

Synonyms: α-Cyperone; (+)-α-Cyperone

Category:

Terpenoids Sesquiterpenes Plants Other Families Extract Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite

alpha-Cyperone (α-Cyperone) is associated with the down-regulation of COX-2, IL-6, Nck-2, Cdc42 and Rac1, resulting in reduction of inflammation, which would be highly beneficial for treatment of inflammatory diseases such as AD.

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4

ZCL278

4 Cited Publications

Cat. No.: HY-13963

CAS No.: 587841-73-4

Purity: 98.49%

Target:

Ras Dengue Virus VSV Arenavirus

Research Areas:

Infection Neurological Disease Metabolic Disease Cancer

ZCL278 is a selective Cdc42 inhibitor with K_ds of 6.4 μM in fluorescence titration and 11.4 μM in surface plasmon resonance (SPR) measurement. ZCL278 is able to disrupt the Cdc42-ITSN interaction as well as GTP/GDP binding. ZCL278 has inhibitory effects on various enveloped viruses, but is ineffective against non-enveloped viruses. ZCL278 can be used for the studies of arsenic neurotoxicity and HER2-positive gastric cancer (GC) .

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3

BDP9066

3 Cited Publications

Cat. No.: HY-111424

CAS No.: 2226507-04-4

Purity: 98.18%

Target:

Cdc42-binding kinase

Research Areas:

Cancer

BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with an IC₅₀ of 64 nM for MRCKβ in SCC12 cells, K_i values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation.

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3

MLS-573151

3 Cited Publications

Cat. No.: HY-113849

CAS No.: 10179-57-4

Purity: 99.70%

Synonyms: MLS000573151

Target:

Ras

Research Areas:

Inflammation/Immunology

MLS-573151 (MLS000573151) is a selective GTPase Cdc42 inhibitor with an EC₅₀ of 2 μM. MLS-573151 is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 and RhoA wild-type. MLS-573151 acts by blocking the binding of GTP to Cdc42 .

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3

(R)-Ketorolac

3 Cited Publications

Cat. No.: HY-B0580B

CAS No.: 66635-93-6

Synonyms: (+)-Ketorolac

Target:

Ras

Research Areas:

Cancer

(R)-Ketorolac is an orally active Cdc42 and Rac1 inhibitor. (R)-Ketorolac inhibits GTPase. (R)-Ketorolac alters ovarian cancer cell behaviors critical for invasion and metastasis. (R)-Ketorolac ameliorates cancer-associated cachexia .

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2

CID44216842

2 Cited Publications

Cat. No.: HY-136379

CAS No.: 1222513-26-9

Purity: 99.84%

Synonyms: CDC42-IN-1

Target:

Ras

Research Areas:

Cancer

CID44216842 (Cdc42-IN-1) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC₅₀s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC₅₀s for Cdc42 WT and Cdc42Q61L mutant are 0.3 and 0.5 μM in GDP binding assay, respectively. Use as a molecular probe .

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2

GNF-7

2 Cited Publications

Cat. No.: HY-10943

CAS No.: 839706-07-9

Purity: 99.70%

Target:

Bcr-Abl Ack1

Research Areas:

Cancer

GNF-7 is a multikinase inhibitor. GNF-7 is a Bcr-Abl inhibitor, with IC₅₀s of 133 nM and 61 nM for Bcr-Abl ^WT and Bcr-Abl ^T315I, respectively. GNF-7 also possesses inhibitory activity against both ACK1 (activated CDC42 kinase 1) and GCK (germinal center kinase) with IC₅₀s of 25 nM and 8 nM, respectively. GNF-7 can be used for the research of hematologic malignancies .

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