63 Results for "

CDK-IN-2

" in MedChemExpress (MCE) Product Catalog:
Products (63)

63 Results for "CDK-IN-2" in MCE Product Catalog:

1
CDK-IN-2
CDK-IN-2
0 Images
1 Cited Publications
Cat. No.: HY-13033
CAS No.: 1269815-17-9
Purity:  98.97%
Synonyms: CDK INhibitor II
Target:  

CDK

Research Areas:  

Endocrinology

CDK-IN-2 is a specific CDK9 inhibitor with an IC50 of less than 8 nM. CDK-IN-2 reduces the phosphorylation level of H3S10. CDK-IN-2 decreases the transition rate of spermatocytes from prophase to metaphase I [2].
loading...
    loading...
View All Sizes
8
Romaciclib monohydrochloride
Romaciclib monohydrochloride
0 Images
8 Publications Verification
Cat. No.: HY-111388A
CAS No.: 2443816-41-7
Purity:  99.29%
Synonyms: SEL120-34A monohydrochloride
Target:  

CDK

Research Areas:  

Cancer

SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50s of 4.4 nM and 10.4 nM, respectively, with a Kd of 3 nM for CDK8. SEL120-34A monohydrochloride weakly inhibits CDK9 (calculated IC50=1070 nM), but shows no obvious activity against CDK1, 2, 4, 6, 5, 7. SEL120-34A monohydrochloride inhibits phosphorylation of STAT1 S727 and STAT5 S726 . Has anti-tumor activity .
loading...
    loading...
View All Sizes
7
BS-181 hydrochloride
BS-181 hydrochloride
0 Images
7 Cited Publications
Cat. No.: HY-13266A
CAS No.: 1397219-81-6
Purity:  99.93%
Target:  

CDK

Research Areas:  

Cancer

BS-181 hydrochloride is a highly selective CDK7 inhibitor with IC50 of 21 nM, and > 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9.
loading...
    loading...
View All Sizes
6
Fadraciclib
Fadraciclib
0 Images
6 Cited Publications
Cat. No.: HY-101212
CAS No.: 1070790-89-4
Purity:  99.50%
Synonyms: CYC065
Target:  

CDK

Research Areas:  

Cancer

Fadraciclib (CYC065) is a second-generation, orally available ATP-competitive inhibitor of CDK2/CDK9 kinases with IC50s of 5 and 26 nM, respectively [2].
loading...
    loading...
View All Sizes
6
GW 5074
GW 5074
0 Images
6 Cited Publications
Cat. No.: HY-10542
CAS No.: 220904-83-6
Purity:  99.49%
Target:  

Raf Apoptosis

Research Areas:  

Cancer

GW 5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, and has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms [2].
loading...
    loading...
View All Sizes
3
(R)​-​CR8
(R)​-​CR8
0 Images
3 Cited Publications
Cat. No.: HY-18340
CAS No.: 294646-77-8
Synonyms: CR8, (R)-Isomer
Target:  

Molecular Glues CDK Apoptosis

Research Areas:  

Neurological Disease Cancer

(R)-CR8, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 induces apoptosis and has neuroprotective effect [2]. (R)-CR8 acts as a molecular glue degrader that depletes cyclin K .
loading...
    loading...
View All Sizes
3
Zotiraciclib
Zotiraciclib
0 Images
3 Cited Publications
Cat. No.: HY-15163
CAS No.: 1204918-72-8
Synonyms: TG02; SB1317
Target:  

JAK CDK FLT3

Research Areas:  

Cancer

Zotiraciclib (TG02; SB1317) is an orally active JAK2/FLT3/CDK2 inhibitor with IC50 values of 13 nM, 73 nM and 56 nM , respectively. Zotiraciclib inhibits cancer cell proliferation, tumor growth and the activity of CYP2D6. Zotiraciclib exhibits high plasma protein binding rate, Caco-2 permeability and tissue distribution capacity, as well as metabolic stability in human and canine liver microsomes. Zotiraciclib achieves tumor growth inhibition in nude mouse models of colon cancer and lymphoma xenografts. Zotiraciclib can be used for research related to colon cancer, B-cell lymphoma, advanced leukemia, acute leukemia and multiple myeloma [2].
loading...
    loading...
View All Sizes
3
(R)-CR8 trihydrochloride
(R)-CR8 trihydrochloride
0 Images
3 Cited Publications
Cat. No.: HY-18340A
CAS No.: 1786438-30-9
Synonyms: CR8, (R)-Isomer trihydrochloride
Target:  

Molecular Glues CDK Apoptosis

Research Areas:  

Neurological Disease Cancer

(R)-CR8 (CR8) trihydrochloride, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 trihydrochloride inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect [2]. (R)-CR8 trihydrochloride acts as a molecular glue degrader that depletes cyclin K .
loading...
    loading...
View All Sizes
1
Halcinonide
Halcinonide
0 Images
1 Cited Publications
Cat. No.: HY-B0877
CAS No.: 3093-35-4
Synonyms: SQ-18566
Target:  

Smo Caspase RAR/RXR CDK

Research Areas:  

Cardiovascular Disease Neurological Disease Inflammation/Immunology

Halcinonide (SQ-18566) is an orally active Smoothened (Smo) agonist. Halcinonide activates the Hedgehog signaling pathway by binding to Smo and promoting its internalization and expression, thereby activating Gli transcription factors. Halcinonide not only stimulates cell proliferation, increases the expression of cyclin D2/CDK6 and inhibits the degradation of caspase-3, but also suppresses Bcl-2/Bax-mediated apoptosis, oxidative stress and inflammatory responses. Halcinonide activates RxRγ to upregulate the expression of myelin genes, thereby reducing cerebral infarction and improving behavioral deficits. Halcinonide has been used in studies related to multiple sclerosis and ischemic stroke [2] .
loading...
    loading...
View All Sizes
PROTAC CDK2/9 Degrader-1
PROTAC CDK2/9 Degrader-1
0 Images
Cat. No.: HY-130709
CAS No.: 2408641-24-5
Purity:  99.85%
Target:  

PROTACs CDK

Research Areas:  

Cancer

PROTAC CDK2/9 Degrader-1 (Compound F3) is a potent dual degrader for CDK2 (DC50=62 nM) and CDK9 (DC50=33 nM). PROTAC CDK2/9 Degrader-1 suppresses prostate cancer PC-3 cell proliferation (IC50=0.12 µM) by effectively blocking the cell cycle in S and G2/M phases. PROTAC CDK2/9 Degrader-1 is a PROTAC by tethering CDK inhibitor with Cereblon ligand .
loading...
    loading...
View All Sizes
CDK2/4/6-IN-2
CDK2/4/6-IN-2
0 Images
Cat. No.: HY-148214
CAS No.: 2531748-80-6
Purity:  98.20%
Target:  

CDK

Research Areas:  

Cancer

CDK2/4/6-IN-2 is a selective CDK2/4/6 inhibitor with IC50 values <1 μM. CDK2/4/6-IN-2 inhibits cells proliferation and phosphorylation of retinoblastoma protein at Ser807/811 in breast cancer cells. CDK2/4/6-IN-2 can be used for the research of cancer, such as breast cancer .
loading...
    loading...
View All Sizes
NVP-LCQ195
NVP-LCQ195
0 Images
Cat. No.: HY-15241
CAS No.: 902156-99-4
Purity:  98.81%
Synonyms: LCQ-195; AT9311
Target:  

CDK

Research Areas:  

Cancer

NVP-LCQ195 (LCQ-195) is an inhibitor of CDK1/2/3/5/9. NVP-LCQ195 induces cell cycle arrest and eventual apoptotic cell death of multiple myeloma (MM) cells. NVP-LCQ195 triggers decreased amplitude of transcriptional signatures related to oncogenesis, drug resistance and stem cell renewal in MM cell lines .
loading...
    loading...
View All Sizes
Cdk1/2 Inhibitor III
Cdk1/2 Inhibitor III
0 Images
Cat. No.: HY-112462
CAS No.: 443798-55-8
Purity:  99.69%
Target:  

CDK

Research Areas:  

Cancer

Cdk1/2 Inhibitor III (compound 3n) is a highly potent and selective Cdk1/cyclin B and Cdk2/cyclin A inhibitor of with IC50s of 0.6 nM and 0.5 nM, respectively. Cdk1/2 Inhibitor III shows selectivity over VEGF-R2 (IC50 of 32 nM), GSK-3β (IC50 of 140 nM), and a other kinases. Cdk1/2 Inhibitor III inhibits in cell proliferation with IC50s of 20 nM, 35 nM and 92 nM for HCT-116, HeLa, and A375 cells, respectively .
loading...
    loading...
View All Sizes
HPN-01
HPN-01
0 Images
Cat. No.: HY-135366
CAS No.: 928655-63-4
Purity:  98.61%
Target:  

IKK

Research Areas:  

Inflammation/Immunology

HPN-01 is a potent and selective IKK inhibitor, with pIC50 values of 6.4, 7.0 and <4.8 for IKK-α, IKK-β and IKK-ε, respectively. HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, and VEGFR-2 .
loading...
    loading...
View All Sizes
TMX-2172
TMX-2172
0 Images
Cat. No.: HY-155218
CAS No.: 2488892-09-5
Target:  

PROTACs CDK

Research Areas:  

Cancer

TMX-2172 is a selective bivalent cereblon-recruiting PROTAC-based dual CDK2 and CDK5 degrader with IC50 values of 6.5 nM and 6.8 nM, respectively. TMX-2172 shows selectivity for CDK2 and CDK5 over other cell cycle CDKs (CDK1, CDK4, and CDK6) and transcriptional CDKs (CDK7 and CDK9). TMX-2172 inhibits CDK2/CDK5 enzymatic activity, induces their proteasomal degradation, reduces ASCL1 protein levels and half-life, induces cancer cell death, and exerts antiproliferative effects. TMX-2172 can be used for the research of ovarian cancer and small cell lung cancer [2] .
loading...
    loading...
View All Sizes
Bruceantinol
Bruceantinol
0 Images
Cat. No.: HY-N8146
CAS No.: 53729-52-5
Category:  

Infection Simaroubaceae Extract Triterpenes 500 - Internal Server Error | MedChemExpress

Oops!

Sorry, Something went wrong on our server.
Our team has been notified and is working to fix the issue.