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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
CERK
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "CERK" in MCE Product Catalog:
3
3 Cited Publications
NVP 231 is a potent, specific, and reversible ceramide kinase (CerK) inhibitor(IC50=12 nM) that competitively inhibits binding of ceramide to CerK . NVP 231 induces cell apoptosis by increasing DNA fragmentation and caspase-3 and caspase-9 cleavage .
Cat. No.: HY-RS02534
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Research Areas:
CERK Human Pre-designed siRNA Set A contains three designed siRNAs for CERK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19583
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Cerk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cerk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS26080
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Cerk Rat Pre-designed siRNA Set A contains three designed siRNAs for Cerk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-12931
CAS No.: 947605-77-8
ERK2-IN-7 is an ATP-competitive ERK2 inhibitor (mouse IC50 = 0.36 μM (cERK2) and 2.6 μM (aERK2); Kd = 0.05 μM (apo ERK2) and 0.14 μM (pERK2)). ERK2-IN-7 binds both inactive and phosphorylated ERK2 and blocks MEK-mediated ERK1/2 phosphorylation through induced-fit conformational changes of the Gly-rich loop and Tyr34, thereby inhibiting p90RSK phosphorylation and proliferation in BRAF-mutant cancer cells. ERK2-IN-7 can be used for research on melanoma and colon cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
