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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
CLC-1
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "CLC-1" in MCE Product Catalog:
Synonyms: NMD670
Target:
Research Areas:
NMD670 is an orally active inhibitor of skeletal muscle specific chloride channel ClC-1 with an EC50 of 1.6 μM. NMD670 enhances neuromuscular transmission and improves muscle contraction and strength. NMD670 can be used in the study of muscle weakness and muscle fatigue [1] .
Target:
Research Areas:
OADS is a Chloride channel antiporter (ClC-ec1) inhibitor (IC50: 29 μM). OADS specifically inhibits the ClC-ec1 antiporter but not the ClC-1 channel. OADS can be used for research of osteoporosis and neurodegenerative and cardiovascular diseases [1].
Cat. No.: HY-P703106
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CLCN1; Chloride Channel Protein 1; Chloride Voltage-Gated Channel 1; Chloride Channel, Voltage-Sensitive 1; CLC-1; Chloride Channel 1, Skeletal Muscle; CLC1; Thomsen Disease, Autosomal Dominant; Chloride Channel Protein, Skeletal Muscle; Uncharacterized P
Species:
Human
Source:
HEK293
Cat. No.: HY-RS02753
Target:
Research Areas:
CLCN1 Human Pre-designed siRNA Set A contains three designed siRNAs for CLCN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-186078
Target:
Research Areas:
SRA-36 is a CLC-K chloride channel inhibitor with selectivity over CLC-5 and CLC-1 chloride channels. SRA-36 blocks CLC-Ka currents with an IC50 of 6.6 μM and a Kd of 3.8 μM. SRA-36 blocks chloride currents mediated by targeted channels, and inhibits currents from hypertension-associated CLC-Ka A447T and CLC-Ka Y315F polymorphisms. SRA-36 can be used for the research of hypertension [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
