100 Results for "

CLL

" in MedChemExpress (MCE) Product Catalog:
Products (100)

100 Results for "CLL" in MCE Product Catalog:

51
Mitoxantrone
Mitoxantrone
0 Images
51 Publications Verification
Cat. No.: HY-13502
CAS No.: 65271-80-9
Purity:  99.58%
Synonyms: Mitozantrone; NSC 301739
Category:  

Infection Disease Research Fields Cancer

Target:  

Topoisomerase PKC Orthopoxvirus Apoptosis

Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity . Mitoxantrone also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .
loading...
    loading...
View All Sizes
51
Mitoxantrone dihydrochloride
Mitoxantrone dihydrochloride
0 Images
51 Publications Verification
Cat. No.: HY-13502A
CAS No.: 70476-82-3
Purity:  99.55%
Synonyms: Mitozantrone dihydrochloride; NSC 301739 dihydrochloride
Category:  

Infection Quinones Anthraquinones Endogenous metabolite Disease Research Fields Cancer

Target:  

Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite

Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .
loading...
    loading...
View All Sizes
37
Acalabrutinib
Acalabrutinib
0 Images
37 Cited Publications
Cat. No.: HY-17600
CAS No.: 1420477-60-6
Synonyms: Calquence; ACP-196
Target:  

Btk

Research Areas:  

Infection Inflammation/Immunology Cancer

Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL). Acalabrutinib can be used for CLL research . Acalabrutinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
loading...
    loading...
View All Sizes
5
Umbralisib
Umbralisib
0 Images
5 Cited Publications
Cat. No.: HY-12279
CAS No.: 1532533-67-7
Purity:  98.94%
Synonyms: TGR-1202; RP5264
Target:  

PI3K Casein Kinase

Research Areas:  

Cancer

Umbralisib (TGR-1202) is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib can be used for haematological malignancies reseach .
loading...
    loading...
View All Sizes
5
MT-802
MT-802
0 Images
5 Cited Publications
Cat. No.: HY-122562
CAS No.: 2231744-29-7
Purity:  98.35%
Target:  

PROTACs Btk

Research Areas:  

Cancer

MT-802 is a BTK PROTAC degrader. MT-802 degrades wild-type BTK (DC50 = 14.6 nM) and BTK mutants including E41K, C481S (DC50 = 14.9 nM), C481R, C481Y, C481T, C481F, L528W, and inhibits their Y223 phosphorylation. BI-4732 can be used for the study of Ibrutinib (HY-10997)-resistant chronic lymphocytic leukemia (CLL). (Pink: BTK ligand (HY-150885), Blue: CRBN Ligand (HY-14658), Black: Linker (HY-141371), E3 ligase ligand-linker conjugate (HY-176340)) .
loading...
    loading...
View All Sizes
5
Umbralisib hydrochloride
Umbralisib hydrochloride
0 Images
5 Cited Publications
Cat. No.: HY-12279C
CAS No.: 1532533-78-0
Purity:  99.04%
Synonyms: TGR-1202 hydrochloride; RP5264 hydrochloride
Target:  

PI3K Casein Kinase

Research Areas:  

Cancer

Umbralisib (TGR-1202) hydrochloride is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib hydrochloride exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib hydrochloride can be used for haematological malignancies reseach .
loading...
    loading...
View All Sizes
4
PRT-060318
PRT-060318
0 Images
4 Cited Publications
Cat. No.: HY-12974
CAS No.: 1194961-19-7
Purity:  98.98%
Synonyms: PRT318
Target:  

Syk Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

PRT-060318 (PRT318) s a potent, selective and orally active tyrosine kinase Syk inhibitor with an IC50 of 3 nM. PRT-060318 suppresses chronic lymphocytic leukemia (CLL) B cell activation and migration, and induces apoptosis. PRT-060318 prevents Heparin (HY-17567)-induced thrombocytopenia and thrombosis in a transgenic mouse model. PRT-060318 dihydrochloride can be used for CLL and thrombus research .
loading...
    loading...
View All Sizes
4
PRT-060318 dihydrochloride
PRT-060318 dihydrochloride
0 Images
4 Cited Publications
Cat. No.: HY-12974A
CAS No.: 3032567-93-1
Synonyms: PRT318 dihydrochloride
Target:  

Syk Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

PRT-060318 (PRT318) dihydrochloride is a potent, selective and orally active tyrosine kinase Syk inhibitor with an IC50 of 3 nM. PRT-060318 dihydrochloride suppresses chronic lymphocytic leukemia (CLL) B cell activation and migration, and induces apoptosis. PRT-060318 dihydrochloride prevents Heparin (HY-17567)-induced thrombocytopenia and thrombosis in a transgenic mouse model. PRT-060318 dihydrochloride can be used for CLL and thrombus research .
loading...
    loading...
View All Sizes
3
Fluorizoline
Fluorizoline
0 Images
3 Cited Publications
Cat. No.: HY-114989
CAS No.: 1362243-70-6
Purity:  99.77%
Target:  

Apoptosis

Research Areas:  

Cancer

Fluorizoline selectively and directly binds to prohibitin 1 (PHB1) and 2 (PHB2), and induces apoptosis. Fluorizoline reduces chronic lymphocytic leukemia (CLL) cell viability through the upregulation of NOXA and BIM. Fluorizoline exerts antitumor action in a p53-independent manner .
loading...
    loading...
View All Sizes
2
Gliotoxin
Gliotoxin
0 Images
2 Cited Publications
Cat. No.: HY-N6727
CAS No.: 67-99-2
Synonyms: Aspergillin
Category:  

Anti-inflammation/Immunoregulatory Disease Research Antibacterial Biological Pesticide Research Other Antibiotics Agricultural Research Infection Microorganisms Antibiotics Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis PKA NF-κB Bacterial Fungal Antibiotic

Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells . Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis . Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells . Gliotoxin is a potent NOTCH2 transactivation inhibitor, can effectively induce apoptosis of chronic lymphocytic leukemia (CLL) cells .
loading...
    loading...
View All Sizes
2
STUB1 Protein, Human
STUB1 Protein, Human
0 Images
2 Cited Publications
Cat. No.: HY-P71340
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: STUB1; CLL-Associated Antigen KW-8; STIP1 Homology And U-Box Containing Protein 1; Antigen NY-CO-7; CHIP; STIP1 Homology And U-Box Containing Protein 1, E3 Ubiquitin Protein Ligase; SDCCAG7; Heat Shock Protein A Binding Protein 2 (C-Terminal); HSPABP2; STIP1 Homology And U Box-Containing Protein 1; NY-CO-7; Serologically Defined Colon Cancer Antigen 7; UBOX1; RING-Type E3 Ubiquitin Transferase; Carboxy Terminus Of Hsp70-Interacting Protein; SCAR16; RING-Type E3 Ubiquitin Transferase CHIP; SCA48; E3 Ubiquitin-Protein Ligase CHIP
Species:  
Human
Source:  
E. coli
loading...
    loading...
View All Sizes
1
Delphinidin 3-glucoside chloride
Delphinidin 3-glucoside chloride
0 Images
1 Cited Publications
Cat. No.: HY-108052
CAS No.: 6906-38-3
Purity:  99.89%
Synonyms: Delphinidin 3-O-glucoside chloride; Delphinidin 3-O-β-glucoside chloride
Category:  

Anthocyans Flavonoids Microorganisms 500 - Internal Server Error | MedChemExpress

Oops!

Sorry, Something went wrong on our server.
Our team has been notified and is working to fix the issue.