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5 Results for "

COLO320DM

" in MedChemExpress (MCE) Product Catalog:

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Zolucatetide

Cat. No.: HY-P10925

CAS No.: 3044032-95-0

Synonyms: FOG-001; I-66

Target:

β-catenin

Research Areas:

Cancer

Zolucatetide (FOG-001;I-66) is a potent β-catenin inhibitor with an IC₅₀ of <50 nM. Zolucatetide can inhibits β-catenin and T-cell factor (TCF) transcription factor interaction. Zolucatetide inhibits cell proliferation and induces cell cycle arrest in target cells. Zolucatetide exhibits anti-tumor efficacy in mice bearing COLO320DM colon cancer cell (with APC, TP53 mutations) xenografts. Zolucatetide can be used for the study of colon cancer .

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August 31

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OM-153

Cat. No.: HY-145267

CAS No.: 2406278-81-5

Purity: 99.59%

Target:

PARP Wnt

Research Areas:

Cancer

OM-153 is a potent and orally active tankyrase inhibitor with IC₅₀s of 13 nM and 2 nM for tankyrase 1 and tankyrase 2 (TNKS1/2), respectively. OM-153 inhibits luciferase-based Wnt/β-catenin signaling reporter activity with an IC₅₀ value of 0.63 nM. OM-153 shows inhibition of Wnt/β-catenin signaling and proliferation in COLO 320DM .

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