151

151 Publications Verification

Synonyms: N-Acetyl-5-methoxytryptamine

Category:

Natural Products Neurological Disease Other disease Anti-aging Disease markers Endogenous metabolite Disease Research Fields Inflammation/Immunology Cancer

Target:

Melatonin Receptor Autophagy Mitophagy Endogenous Metabolite Apoptosis PANoptosis Ligands for Target Protein for PROTAC Histone Acetyltransferase

Melatonin is a hormone made by the pineal gland that can activate melatonin receptor and inhibit PANoptosis. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties . Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation . Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress .

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94

Methotrexate

94 Cited Publications

Cat. No.: HY-14519

CAS No.: 59-05-2

Purity: 99.87%

Synonyms: Amethopterin; CL14377; WR19039

Target:

Antifolate Dihydrofolate reductase (DHFR) NO Synthase COX Interleukin Related

Research Areas:

Inflammation/Immunology Cancer

Methotrexate (Amethopterin; CL14377; WR19039) is an orally active antifolate (Antifolate). Methotrexate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .

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94

Methotrexate hydrate

94 Cited Publications

Cat. No.: HY-14519B

CAS No.: 133073-73-1

Purity: 98.41%

Synonyms: Amethopterin hydrate; CL14377 hydrate; WR19039 hydrate

Target:

Antifolate Dihydrofolate reductase (DHFR) NO Synthase COX Interleukin Related

Methotrexate hydrate (Amethopterin hydrate; CL14377 hydrate; WR19039 hydrate) is an orally active antifolate (Antifolate). Methotrexate hydrate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate hydrate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate hydrate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate hydrate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .

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94

Methotrexate disodium

94 Cited Publications

Cat. No.: HY-14519A

CAS No.: 7413-34-5

Purity: 99.71%

Synonyms: Amethopterin disodium; CL14377 disodium; WR19039 disodium

Target:

Antifolate Dihydrofolate reductase (DHFR) NO Synthase COX Interleukin Related

Methotrexate disodium (Amethopterin disodium; CL14377 disodium; WR19039 disodium) is an orally active antifolate (Antifolate). Methotrexate disodium inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate disodium promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate disodium induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate disodium is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .

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89

Indomethacin

89 Cited Publications

Cat. No.: HY-14397

CAS No.: 53-86-1

Purity: 99.91%

Synonyms: Indometacin

Target:

COX Antibiotic Influenza Virus Bacterial

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research .

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89

Indomethacin sodium hydrate

89 Cited Publications

Cat. No.: HY-14397A

CAS No.: 74252-25-8

Purity: 99.85%

Synonyms: Indometacin sodium hydrate

Target:

COX Bacterial Influenza Virus Antibiotic

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Indomethacin (Indometacin) sodium hydrateis a orally active and BBB-permeable COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium hydrateis has anticancer activity and anti-infective activity. Indomethacin sodium hydrateis can be used for cancer, inflammation and viral infection research .

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78

Acetaminophen

78 Cited Publications

Cat. No.: HY-66005

CAS No.: 103-90-2

Synonyms: Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide

Category:

Alkaloids Monophenols Other Alkaloids Phenols Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Environmental Pollutants Endogenous Metabolite COX Histone Acetyltransferase Parasite Bacterial Ferroptosis

Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent. . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor . Acetaminophen induces ferroptosis and leads to acute liver injury in mice model .

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70

Celecoxib

70 Cited Publications

Cat. No.: HY-14398

CAS No.: 169590-42-5

Purity: 99.89%

Synonyms: SC 58635

Target:

COX

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Celecoxib,a selective and BBB-permeable non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

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52

Oxidopamine hydrochloride

52 Cited Publications

Cat. No.: HY-B1081

CAS No.: 28094-15-7

Synonyms: 6-Hydroxydopamine Hydrochloride

Target:

Dopamine Receptor Autophagy Mitophagy COX PGE synthase Interleukin Related p38 MAPK Apoptosis Caspase

Research Areas:

Neurological Disease Cancer

Oxidopamine (6-OHDA) hydrochloride is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrochloride is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrochloride promotes COX-2 activation, leading to PGE₂ synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrochloride can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome .

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52

Oxidopamine hydrobromide

52 Cited Publications

Cat. No.: HY-B1081A

CAS No.: 636-00-0

Synonyms: 6-Hydroxydopamine hydrobromide; 6-OHDA hydrobromide

Target:

Dopamine Receptor Autophagy Mitophagy COX PGE synthase Interleukin Related p38 MAPK Apoptosis Caspase

Research Areas:

Neurological Disease Cancer

Oxidopamine (6-OHDA) hydrobromide is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrobromide is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrobromide promotes COX-2 activation, leading to PGE₂ synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrobromide can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome .

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39

Aspirin

39 Cited Publications

Cat. No.: HY-14654

CAS No.: 50-78-2

Purity: 99.67%

Synonyms: Acetylsalicylic acid; ASA

Target:

Environmental Pollutants Autophagy NF-κB Apoptosis COX Mitophagy Virus Protease Caspase p38 MAPK

Research Areas:

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC₅₀ values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis .

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26

Diclofenac

26 Cited Publications

Cat. No.: HY-15036

CAS No.: 15307-86-5

Purity: 99.92%

Target:

COX Apoptosis

Research Areas:

Inflammation/Immunology Cancer

Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

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26

Diclofenac potassium

26 Cited Publications

Cat. No.: HY-15038

CAS No.: 15307-81-0

Purity: 99.99%

Target:

COX Apoptosis

Research Areas:

Inflammation/Immunology Cancer

Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

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26

Diclofenac Sodium

26 Cited Publications

Cat. No.: HY-15037

CAS No.: 15307-79-6

Purity: 99.94%

Synonyms: GP 45840

Target:

COX Apoptosis

Research Areas:

Inflammation/Immunology Cancer

Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

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26

Diclofenac diethylamine

26 Cited Publications

Cat. No.: HY-15036A

CAS No.: 78213-16-8

Purity: 99.95%

Target:

COX Apoptosis

Research Areas:

Inflammation/Immunology Cancer

Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC₅₀s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .

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