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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
CRS
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "CRS" in MCE Product Catalog:
15
15 Publications Verification
Synonyms: Tip60 HAT inhibitor
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
MG149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50 = 47 uM); little potent for PCAF and p300 (IC50 >200 uM). MG 149 inhibits KAT8 and blocks PINK1 kinase activity. MG149 inhibits the phosphorylation of Parkin and ubiquitin, thereby suppressing the initiation of PINK1-dependent mitophagy. MG 149 can reverse chronic restraint stress (CRS) induced hypertension and related molecular changes. MG 149 commonly used in research on diseases such as hypertension and Parkinson's disease .
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Target:
Research Areas:
CRS3123 (REP-3123) is an orally active antibacterial agent that targets methionyl-tRNA synthetase (MetRS). CRS3123 competitively displaces methionine from the active site of MetRS, preventing tRNA charging and protein synthesis, and exhibits greater selectivity for C. difficile MetRS than for human MetRS and Gram-negative bacterial MetRS. CRS3123 can be used in research on Clostridioides difficile infection and vancomycin-resistant enterococcal infection .
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1 Cited Publications
Synonyms: REP-3123 dihydrochloride
Target:
Research Areas:
CRS3123 dihydrochloride (REP-3123 dihydrochloride) is an orally active antibacterial agent that targets methionyl-tRNA synthetase (MetRS). CRS3123 dihydrochloride competitively displaces methionine from the active site of MetRS, preventing tRNA charging and protein synthesis, and exhibits greater selectivity for C. difficile MetRS than for human MetRS and Gram-negative bacterial MetRS. CRS3123 dihydrochloride can be used in research on Clostridioides difficile infection and vancomycin-resistant enterococcal infection .
Cat. No.: HY-P9975
CAS No.: 906068-56-2
Synonyms: TGN1412; TAB08
Target:
Research Areas:
Theralizumab (TGN1412) is a humanized lgG4 superagonistic anti-CD28 monoclonal antibody that directly stimulates T cells. Theralizumab can cause cytokine release syndrome (CRS). Theralizumab can be used for the research of rheumatoid arthritis .
Category:
Human Gut Microbiota Metabolites Microorganisms Neurological Disease Ketones, Aldehydes, Acids Phenols Polyphenols Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-115440R
CAS No.: 1013915-99-5
Synonyms: REP-3123 dihydrochloride (Standard)
Target:
Research Areas:
CRS3123 dihydrochloride (Standard) (REP-3123 dihydrochloride (Standard)) is the analytical standard of CRS3123 dihydrochloride (HY-115440). This product is intended for research and analytical applications. CRS3123 dihydrochloride (REP-3123 dihydrochloride) is an orally active antibacterial agent that targets methionyl-tRNA synthetase (MetRS). CRS3123 dihydrochloride competitively displaces methionine from the active site of MetRS, preventing tRNA charging and protein synthesis, and exhibits greater selectivity for C. difficile MetRS than for human MetRS and Gram-negative bacterial MetRS. CRS3123 dihydrochloride can be used in research on Clostridioides difficile infection and vancomycin-resistant enterococcal infection .
Cat. No.: HY-RS15281
Target:
Research Areas:
TWIST1 Human Pre-designed siRNA Set A contains three designed siRNAs for TWIST1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-175508
Target:
Research Areas:
NMDA receptor modulator 9 is an orally active NMDA receptor positive allosteric modulator (PAM). NMDA receptor modulator 9 enhances GluN2A receptor activity. NMDA receptor modulator 9 demonstrates significant antidepressant-like effects in chronic restraint stress (CRS)-induced depression mice. NMDA receptor modulator 9 can be used for the study of depression .
Cat. No.: HY-P70042
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CRISP3; CRS3; Cysteine Rich Secretory Protein 3; Aeg2; CRISP-3; Cysteine-Rich Secretory Protein 3; SGP28; Specific Granule Protein Of 28 KDa; DJ442L6.3; Specific Granule Protein (28 KDa)
Species:
Human
Source:
HEK293
Cat. No.: HY-P81173
Synonyms: ACS3; B-HLH DNA binding protein; bHLHa38; BPES2; BPES3; Class A basic helix-loop-helix protein 38; CRS1; H-twist; OTTHUMP00000116043; SCS; Twist basic helix loop helix transcription factor 1; Twist homolog 1 (Drosophila); Twist homolog 1; TWIST homolog of drosophila; Twist related protein 1; Twist-related protein 1; Twist1; TWST1_HUMAN.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
