12

Echinomycin

12 Publications Verification

Cat. No.: HY-106101

CAS No.: 512-64-1

Purity: 98.57%

Synonyms: Quinomycin A; NSC-13502

Target:

HIF/HIF Prolyl-Hydroxylase Antibiotic Bacterial

Research Areas:

Cancer

Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC₅₀ of 29.4 pM .

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12

Vps34-PIK-III

12 Publications Verification

Cat. No.: HY-12794

CAS No.: 1383716-40-2

Purity: 99.63%

Target:

PI3K Autophagy

Research Areas:

Neurological Disease Cancer

Vps34-PIK-III is an orally active and selective VPS34 inhibitor (IC₅₀=18 nM). Vps34-PIK-III effectively inhibits autophagy and can be used as a molecular tool. vps34-PIK-III is also a PI3K inhibitor that inhibits the expression of genes in liver cancer stem cells (CSCs) .

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11

Phenformin hydrochloride

11 Cited Publications

Cat. No.: HY-16397A

CAS No.: 834-28-6

Synonyms: Phenethylbiguanide hydrochloride

Target:

Apoptosis mTOR Autophagy Mitochondrial Metabolism AMPK

Research Areas:

Neurological Disease Metabolic Disease Cancer

Phenformin (Phenethylbiguanide) hydrochloride is an orally active biguanide hypoglycemic agent. Phenformin hydrochloride inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy. Phenformin hydrochloride inhibits cancer stem cells (CSCs) and possesses potent antitumor potential .

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11

Phenformin

11 Cited Publications

Cat. No.: HY-16397

CAS No.: 114-86-3

Synonyms: Phenethylbiguanide

Target:

Mitochondrial Metabolism AMPK Apoptosis Autophagy mTOR

Research Areas:

Neurological Disease Metabolic Disease Cancer

Phenformin (Phenethylbiguanide) is an orally active biguanide hypoglycemic agent. Phenformin inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy. Phenformin inhibits cancer stem cells (CSCs) and possesses potent antitumor potential .

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7

CWP232228

7 Cited Publications

Cat. No.: HY-18959

CAS No.: 1144044-02-9

Target:

β-catenin Wnt

Research Areas:

Cancer

CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 suppresses tumor formation and metastasis without toxicity through the inhibition of the growth of breast and liver cancer stem cells (CSCs) .

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6

Thioridazine hydrochloride

6 Cited Publications

Cat. No.: HY-B0965

CAS No.: 130-61-0

Target:

Dopamine Receptor Apoptosis 5-HT Receptor Autophagy Bacterial

Research Areas:

Infection Neurological Disease Cancer

Thioridazine hydrochloride, an orally active antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine hydrochloride is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine hydrochloride shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs) .

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6

Thioridazine

6 Cited Publications

Cat. No.: HY-B0965A

CAS No.: 50-52-2

Target:

Dopamine Receptor Apoptosis 5-HT Receptor Autophagy Bacterial

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs) .

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5

Benztropine mesylate

5 Cited Publications

Cat. No.: HY-B0520A

CAS No.: 132-17-2

Synonyms: Benzatropine mesylate; Benzotropine mesylate; Benztropine methanesulfonate

Target:

Dopamine Receptor mAChR Histamine Receptor

Research Areas:

Infection Neurological Disease Metabolic Disease Cancer

Benztropine mesylate (Benzatropine mesylate) is an orally active and BBB-permeable centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D₂ dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects .

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5

Benztropine

5 Cited Publications

Cat. No.: HY-B0520

CAS No.: 86-13-5

Synonyms: Benzatropine; Benzotropine

Target:

Dopamine Receptor mAChR Histamine Receptor

Research Areas:

Cancer

Benztropine (Benzatropine; Benzotropine) is an orally active and BBB-permeable centrally acting anticholinergic agent that can be used for Parkinson's disease research . Benztropine is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine is also a human D₂ dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects .

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2

ALDH1A inhibitor 673A

2 Cited Publications

Cat. No.: HY-122912

CAS No.: 109437-62-9

Purity: 99.15%

Synonyms: ALDH1Ai 673A

Target:

Aldehyde Dehydrogenase (ALDH) Mitochondrial Metabolism Necroptosis

Research Areas:

Cancer

ALDH1A inhibitor 673A is an ALDH1A inhibitor with IC₅₀s of 246 nM (ALDH1A1), 230 nM (ALDH1A2), 348 nM (ALDH1A3), respectively. ALDH1A inhibitor 673A has little or no inhibitory effect on other ALDH family members. ALDH1A inhibitor 673A induces necroptotic ovarian cancer stem-like cells (CSCs) death. ALDH1A inhibitor 673A induces DNA double stand breaks in cancer cells. ALDH1A inhibitor 673A can be used for the study of ovarian cancer .

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2

YB-0158

2 Cited Publications

Cat. No.: HY-136541

CAS No.: 1144043-83-3

Purity: 99.80%

Synonyms: Wnt pathway inhibitor 2

Target:

Wnt Apoptosis

Research Areas:

Cancer

YB-0158 (Wnt pathway inhibitor 2) is a reverse-turn peptidomimetic and a potent colorectal cancer stem cell (CSC) targeting agent. YB-0158 disrupts Sam68-Src interactions and induces apoptosis in CRC cells. Anti-cancer activities .

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1

Lumiflavin

1 Cited Publications

Cat. No.: HY-121608

CAS No.: 1088-56-8

Purity: 99.79%

Synonyms: Lumiflavine

Lumiflavin (Lumiflavine), a riboflavine analog, causes significant inhibition of riboflavine uptake. Lumiflavin can effectively reduce the riboflavin enrichment in cancer stem-like cells (CSCs) and sensitize the effect of cisplatin Diamminedichloroplatinum (DDP) on CSCs. Lumiflavin is promising for research of ovarian cancer .

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1

Chetomin

1 Cited Publications

Cat. No.: HY-107553

CAS No.: 1403-36-7

Purity: 95.3%

Target:

HSP Apoptosis

Research Areas:

Cancer

Chetomin, an active component of Chaetomium globosum, is a heat shock protein 90/hypoxia-inducible factor 1 alpha (Hsp90/HIF1α) pathway inhibitor. Chetomin is a potent, nontoxic non-small cell lung cancer cancer stem cells (NSCLC CSC)-targeting molecule .

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1

CM037

1 Cited Publications

Cat. No.: HY-110294

CAS No.: 896795-60-1

Purity: 99.55%

Synonyms: A37

Target:

Aldehyde Dehydrogenase (ALDH)

Research Areas:

Cancer

CM037 is a highly selective and competitive ALDH1A1 inhibitor (IC₅₀=4.6 μM). CM037 blocks the catalytic activity of ALDH1A1, thereby inhibiting the activation of the downstream HIF-1α/VEGF pathway. CM037 is mainly used to study the ALDH1A1-mediated regulation of cancer stem cells (CSCs) and angiogenesis, especially in breast cancer, showing the potential to inhibit tumor angiogenesis and stem cell characteristics .

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1

MC1742

1 Cited Publications

Cat. No.: HY-110280

CAS No.: 1776116-74-5

Purity: 99.20%

Target:

HDAC Apoptosis

Research Areas:

Cancer

MC1742 is a potent HDAC inhibitor, with IC₅₀s of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 and HDAC11, respectively. MC1742 can increase acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells growth. MC1742 can induce growth arrest, apoptosis, and differentiation in sarcoma CSC .

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