Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
80 Results for "
CTLs
" in MedChemExpress (MCE) Product Catalog:
Products (80)
80 Results for "CTLs" in MCE Product Catalog:
19
19 Publications Verification
Synonyms: Salinosporamide A; NPI-0052
Target:
2
Target:
Research Areas:
2
1
1 Cited Publications
Cat. No.: HY-P990255
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-160768
Target:
Research Areas:
OTUB2-IN-1, a specific inhibitor of OTUB2 (KD: ~12 μM), reduces PD-L1 protein expression in tumor cells and inhibits tumor growth by promoting robust intra-tumor infiltration of cytotoxic T lymphocytes (CTL) .
1
1 Cited Publications
Cat. No.: HY-P10869
Research Areas:
Cat. No.: HY-163028
CAS No.: 459789-75-4
ML-T7 is a potent Tim-3 inhibitor. ML-T7 blocks Tim-3 interactions with PtdSer and CEACAM1. ML-T7 not only enhances the antitumor activity of adoptive transfer therapy with cytotoxic T lymphocytes (CTLs) and CAR T cells but also increases the effector function of T cell. ML-T7 promotes NK cells’ killing activity against tumor cells and DC antigen-presenting capacity. ML-T7 directly exerts antitumor efficacy in preclinical tumor models either alone or in combination with Nivolumab (HY-P9903A). ML-T7 can be used for tumor immunotherapy research .
Target:
Research Areas:
PNU-159682 carboxylic acid (Compound 53) is a potent ADCs cytotoxin and encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. PNU-159682 carboxylic acid has protein fold and diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response .
Cat. No.: HY-172240
CAS No.: 1418305-55-1
Synonyms: TU2218 free base
Research Areas:
Tosposertib (TU2218 free base) is an ALK5/VEGFR2 dual inhibitor (IC50 = 1.2 nM/4.9 nM). Tosposertib directly restores the activity of damaged cytotoxic T lymphocytes (CTLs) and natural killer cells inhibited by TGFβ and suppresses the activity and viability of regulatory T cells. Tosposertib can be used for the study of melanoma and colon cancer .
Cat. No.: HY-P1907
CAS No.: 151812-18-9
Cat. No.: HY-P990795
Target:
Research Areas:
Cat. No.: HY-P0277
CAS No.: 168635-85-6
Synonyms: CEA peptide
Target:
Proteasome Apoptosis Autophagy Caspase Bcl-2 Family NF-κB PARP
Research Areas:
PI-1840 is a potent and selective chymotrypsin-like (CT-L) inhibitor for with an IC50 value of 27 nM. PI-1840 inhibits cell proliferation and arrest cell cycle at G2/M phase. PI-1840 induces apoptosis and induces autophagy. PI-1840 induces the accumulation of proteasome substrates p27, Bax, and IκB-α .
Cat. No.: HY-P2527
CAS No.: 187671-49-4
Target:
Research Areas:
Tyrosinase-related Protein 2 (TRP-2) (181-188) is a peptide epitope of the TRP-2 protein that conforms to the MHC class I H2-Kb binding motif. It is the major reactive epitope within TRP-2 recognized by anti-B16 CTLs, induces TRP-2-specific CTL and CD8 + T cell responses, and mediates antibody-dependent antitumor effects against lung metastasis. Tyrosinase-related Protein 2 (TRP-2) (181-188) is used in melanoma research .
Cat. No.: HY-P5470
CAS No.: 152274-91-4
Research Areas:
Cat. No.: HY-P2455
CAS No.: 137856-41-8
Synonyms: Listeriolysin O (91-99)
Target:
Research Areas:
CAMK1D-IN-1 (compound I) is an inhibitor of CAMK1D, targeting cytotoxic T lymphocyte (CTL)-resistant tumor cells. CAMK1D impairs CTL-induced death receptor signaling and apoptosis by inhibiting caspases, making it a key and effective target for PD-L1-refractory tumors .
Cat. No.: HY-161982
CAS No.: 3079468-41-7
Target:
Research Areas:
JNU-0921 is a potent and orally active CD137 agonist. JNU-0921 increases the mRNA expression of IFN-γ and GZMB. JNU-0921 induces luciferase activity with an EC50 value of 64.07 nM.JNU-0921 enhances effector and memory function of cytotoxic CD8 + T cells (CTLs) and alleviates their exhaustion. JNU-0921 also skews polarization of helper T cells toward T helper 1 type and enhances their activity to boost CTL function. JNU-0921 shows anticancer activity .
Target:
Research Areas:
BT317 is a blood-brain transmissible mitochondrial Lon peptidase I (LonP1) and CT-L proteasome inhibitor. BT317 can increase the production of reactive oxygen species (ROS) and induce apoptosis in astrocytoma cells. BT317 has antitumor activity .
Target:
Research Areas:
Enzyme-IN-1 (compound 1) is a peptide-based inhibitor of N-terminal nucleophile (Ntn) hydrolases. Specifically, Enzyme-IN-1 inhibits the chymotrypsin-like activity (CT-L) of the 20S proteasome. Enzyme-IN-1 may has potential antiinflammatory properties .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
