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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
CUL1
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "CUL1" in MCE Product Catalog:
25
25 Cited Publications
Target:
Research Areas:
CSN5i-3 is a potent, selective and orally available inhibitor of CSN5/Jab1, and inhibits CSN-catalysed Cul1 deneddylation with an IC50 value of 5.8 nM [1].
1
1 Cited Publications
Target:
Research Areas:
KH-4-43 is an inhibitor of E3 CRL4. KH-4-43 inhibits E3 CRL4's core ligase complex and exhibits anticancer activity. KH-4-43 has a binding Kd to E3 ROC1-CUL4A CTD or the highly related ROC1-CUL1 CTD at 83 nM or 9.4 μM, respectively [1].
Target:
Research Areas:
HB007 is a SUMO1 molecular glue degrader targeting CAPRIN1 and FBXO42. HB007 selectively binds CAPRIN1 to induce CAPRIN1-FBXO42 interaction, recruits SUMO1 to the CAPRIN1-CUL1-FBXO42 E3 ligase complex, and drives SUMO1 ubiquitination and degradation without affecting SUMO2/3. HB007 induces TCF4 deSUMOylation and proteasomal degradation to inhibit StarD7 transcriptional activity, reduces StarD7 mRNA and protein levels, and triggers ER stress and ROS production. HB007 can be used for the research of brain cancer, breast cancer, colon cancer, lung cancer [1] .
Cat. No.: HY-RS03359
Target:
Research Areas:
CUL1 Human Pre-designed siRNA Set A contains three designed siRNAs for CUL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS27837
Target:
Research Areas:
Cul1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cul1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS21318
Target:
Research Areas:
Cul1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cul1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-159601
Target:
Research Areas:
CSN5-IN-1 (compound Ac-11) is an inhibitor of CSN5, with IC50 values of 12.56 μM and 19 μM as measured by FP assay and fluorescence assay, respectively. CSN5-IN-1 can also downregulate the expression of PD-L1 and upregulate the expression of NEDD8-Cul1 in cells [1].
Cat. No.: HY-162240
Target:
Research Areas:
SJH1-51B is a SKP1-recruiting BRD4 PROTAC degrader. SJH1-51B binds to SKP1 in the SKP1-FBXO7-CUL1-RBX1 complex, but shows no or weak binding to monomeric SKP1. SJH1-51B induces proteasome- and SKP1-dependent degradation of BRD4, and this degradation process relies on the neddylation modification of Cullin-RING E3 ligase. SJH1-51B induces proteasome-mediated degradation of the short isoform of BRD4 in non-cancer cells, while it induces proteasome-mediated degradation of both the long and short isoforms of BRD4 in breast cancer cells. SJH1-51B can be used for breast cancer research [1].
Cat. No.: HY-P703243
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CUL1; CULlin-1; CULlin 1; CUL-1; RBX1; E3 Ubiquitin-Protein Ligase RBX1; Ring-Box 1; RING Finger Protein 75; RNF75; RING-Box Protein 1; ROC1; Ring-Box 1, E3 Ubiquitin Protein Ligase; Regulator Of CULlins 1; ZYP Protein; BA554C12.1; Protein ZYP; E3 Ubiquit
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703242
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CUL1; CULlin-1; CULlin 1; CUL-1; RBX1; E3 Ubiquitin-Protein Ligase RBX1; Ring-Box 1; RING Finger Protein 75; RNF75; RING-Box Protein 1; ROC1; Ring-Box 1, E3 Ubiquitin Protein Ligase; Regulator Of CULlins 1; ZYP Protein; BA554C12.1; Protein ZYP; E3 Ubiquitin-Protein Transferase RBX1; Rbx1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-181795
Target:
Research Areas:
CSN5-IN-3 (Compound 30) is a CSN5 inhibitor with an IC50 of 0.58 μM. CSN5-IN-3 inhibits the enzymatic activity of CSN5, leading to increased accumulation of NEDD8-Cul1 and promoting the degradation of PD-L1. CSN5-IN-3 downregulates Bcl-2, and upregulates P53 and Cleaved caspase-3. CSN5-IN-3 exhibits anticancer activity against triple-negative breast cancer [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
