42

AMG 487

42 Publications Verification

Cat. No.: HY-15319

CAS No.: 473719-41-4

Purity: 99.80%

Target:

CXCR

Research Areas:

Inflammation/Immunology Endocrinology Cancer

AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC₅₀s of 8.0 and 8.2 nM, respectively .

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9

NBI-74330

9 Cited Publications

Cat. No.: HY-15320

CAS No.: 855527-92-3

Purity: 99.76%

Target:

CXCR

Research Areas:

Inflammation/Immunology Endocrinology

NBI-74330 is a potent antagonist for CXCR3, and exhibits potent inhibition of ( ¹²⁵I)CXCL10 and ( ¹²⁵I)CXCL11 specific binding with K_i of 1.5 and 3.2 nM, respectively.

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2

CXCR7 antagonist-1

2 Cited Publications

Cat. No.: HY-139643

CAS No.: 1613021-99-0

Purity: 99.85%

Target:

CXCR Adrenergic Receptor

Research Areas:

Inflammation/Immunology Cancer

CXCR7 antagonist-1 is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. CXCR7 antagonist-1 is useful in preventing tumor cell proliferation, tumor formation, inflammatory diseases, and many other diseases .

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2

CXCR7 antagonist-1 hydrochloride

2 Cited Publications

Cat. No.: HY-139643A

CAS No.: 2990472-61-0

Purity: 99.41%

Target:

CXCR Adrenergic Receptor

Research Areas:

Inflammation/Immunology Cancer

CXCR7 antagonist-1 hydrochloride is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. CXCR7 antagonist-1 hydrochloride is useful in preventing tumor cell proliferation, tumor formation, inflammatory diseases, and many other diseases .

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1

I-TAC/CXCL11 Protein, Human (HEK293)

1 Cited Publications

Cat. No.: HY-P7228

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: CXCL11; Interferon Gamma-Inducible Protein 9; Prev. SCYB11; C-X-C Motif Chemokine 11; Prev. SCYB9B; Beta-R1; I-TAC; Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 9B; H174; Small Inducible Cytokine B11; IP-9; Small-Inducible Cytokine B11; B-R1; Alternative Protein CXCL11; Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 11; ITAC; Interferon-Inducible T-Cell Alpha Chemoattractant; IP9; C-X-C Motif Chemokine Ligand 11; Chemokine (C-X-C Motif) Ligand 11

Species:

Human

Source:

HEK293

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1

Animal-Free I-TAC/CXCL11 Protein, Mouse (His)

1 Cited Publications

Cat. No.: HY-P700169AF

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: CXCL11; Interferon Gamma-Inducible Protein 9; Prev. SCYB11; C-X-C Motif Chemokine 11; Prev. SCYB9B; Beta-R1; I-TAC; Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 9B; H174; Small Inducible Cytokine B11; IP-9; Small-Inducible Cytokine B11; B-R1;

Species:

Mouse

Source:

E. coli

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1

I-TAC/CXCL11 Protein, Human

1 Cited Publications

Cat. No.: HY-P7229

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: CXCL11; Interferon Gamma-Inducible Protein 9; Prev. SCYB11; C-X-C Motif Chemokine 11; Prev. SCYB9B; Beta-R1; I-TAC; Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 9B; H174; Small Inducible Cytokine B11; IP-9; Small-Inducible Cytokine B11; B-R1;

Species:

Human

Source:

E. coli

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ACT-777991

Cat. No.: HY-149055

CAS No.: 1967811-46-6

Purity: 99.49%

Target:

CXCR

Research Areas:

Inflammation/Immunology

ACT-777991 is an orally active and selective CXCR3 antagonist. ACT-777991 has microsomes and hepatocytes stability across animal models. ACT-777991 inhibits the migration of activated T cells toward CXCL11 .

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SCH-900875

Cat. No.: HY-165428

CAS No.: 907206-98-8

Target:

CXCR Arrestin

Research Areas:

Inflammation/Immunology

SCH-900875 is an orally active, brain-penetrant and selective CXCR3 receptor inhibitor, which also shows high selectivity over CXCR1 and CXCR2 receptors. SCH-900875 binds to CXCR3, blocking the binding of ligands CXCL9, CXCL10, and CXCL11, inhibiting downstream G protein and β-arrestin signaling pathways to suppress inflammatory cell migration. SCH-900875 is promising for research of autoimmune diseases (rheumatoid arthritis, multiple sclerosis) and inflammatory disorders (psoriasis, inflammatory bowel disease) .

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CXCL11 Human Pre-designed siRNA Set A

Cat. No.: HY-RS03385

Target:

Small Interfering RNA (siRNA)

Research Areas:

Others

CXCL11 Human Pre-designed siRNA Set A contains three designed siRNAs for CXCL11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cxcl11 Rat Pre-designed siRNA Set A

Cat. No.: HY-RS23142

Target:

Small Interfering RNA (siRNA)

Research Areas:

Others

Cxcl11 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cxcl11 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cxcl11 Mouse Pre-designed siRNA Set A

Cat. No.: HY-RS16707

Target:

Small Interfering RNA (siRNA)

Research Areas:

Others

Cxcl11 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cxcl11 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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(±)-AMG 487

Cat. No.: HY-15319A

CAS No.: 947536-03-0

Target:

CXCR

Research Areas:

Cancer

(±)-AMG 487 is a racemate of AMG 487. AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC₅₀s of 8.0 and 8.2 nM, respectively .

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