383 Results for "

CYP 3A4

" in MedChemExpress (MCE) Product Catalog:
Products (383)

383 Results for "CYP 3A4" in MCE Product Catalog:

98
Verapamil
Verapamil
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98 Publications Verification
Cat. No.: HY-14275
CAS No.: 52-53-9
Purity:  98.96%
Synonyms: (±)-Verapamil; CP-16533-1
Target:  

Calcium Channel P-glycoprotein Cytochrome P450

Research Areas:  

Cardiovascular Disease Metabolic Disease Cancer

Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research .
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98
Verapamil hydrochloride
Verapamil hydrochloride
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98 Publications Verification
Cat. No.: HY-A0064
CAS No.: 152-11-4
Synonyms: (±)-Verapamil hydrochloride; CP-16533-1 hydrochloride
Target:  

Calcium Channel P-glycoprotein Cytochrome P450

Research Areas:  

Cardiovascular Disease Cancer

Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research .
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36
Fenofibrate
Fenofibrate
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36 Cited Publications
Cat. No.: HY-17356
CAS No.: 49562-28-9
Target:  

PPAR Cytochrome P450 Autophagy

Research Areas:  

Cardiovascular Disease Cancer

Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.
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32
Ketoconazole
Ketoconazole
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32 Cited Publications
Cat. No.: HY-B0105
CAS No.: 65277-42-1
Synonyms: Ketoconazol; R 41400
Target:  

Fungal Cytochrome P450 Ras Bacterial

Research Areas:  

Infection Cancer

Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
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31
Capmatinib
Capmatinib
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31 Cited Publications
Cat. No.: HY-13404
CAS No.: 1029712-80-8
Purity:  99.75%
Synonyms: INC280; INCB28060
Target:  

c-Met/HGFR Apoptosis

Research Areas:  

Cancer

Capmatinib (INC280; INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib is largely metabolized by CYP3A4 and aldehyde oxidase .
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31
Capmatinib dihydrochloride
Capmatinib dihydrochloride
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31 Cited Publications
Cat. No.: HY-13404A
CAS No.: 1197376-85-4
Synonyms: INC280 dihydrochloride; INCB28060 dihydrochloride
Target:  

c-Met/HGFR Apoptosis

Research Areas:  

Cancer

Capmatinib (INC280; INCB28060) dihydrochloride is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib dihydrochloride can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride is largely metabolized by CYP3A4 and aldehyde oxidase .
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31
Capmatinib hydrochloride
Capmatinib hydrochloride
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31 Cited Publications
Cat. No.: HY-13404B
CAS No.: 1029714-89-3
Purity:  99.60%
Synonyms: INC280 hydrochloride; INCB-28060 hydrochloride
Target:  

c-Met/HGFR Apoptosis

Research Areas:  

Cancer

Capmatinib (INC280; INCB28060) hydrochloride is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib hydrochloride can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib hydrochloride potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib hydrochloride is largely metabolized by CYP3A4 and aldehyde oxidase .
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31
Capmatinib dihydrochloride hydrate
Capmatinib dihydrochloride hydrate
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31 Cited Publications
Cat. No.: HY-13404C
CAS No.: 1865733-40-9
Purity:  99.78%
Synonyms: INC280 dihydrochloride hydrate; INCB-28060 dihydrochloride hydrate
Target:  

c-Met/HGFR Apoptosis

Research Areas:  

Cancer

Capmatinib (INC280; INCB28060) dihydrochloride hydrate is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib dihydrochloride hydrate can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride hydrate potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride hydrate is largely metabolized by CYP3A4 and aldehyde oxidase .
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23
Clarithromycin
Clarithromycin
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23 Cited Publications
Cat. No.: HY-17508
CAS No.: 81103-11-9
Target:  

Bacterial Cytochrome P450 Autophagy Antibiotic

Research Areas:  

Infection Cancer

Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM . Clarithromycin significantly inhibits the HERG potassium current .Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K .
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18
Piperine
Piperine
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18 Cited Publications
Cat. No.: HY-N0144
CAS No.: 94-62-2
Synonyms: Bioperine; 1-Piperoylpiperidine
Category:  

Piperaceae Extract Plants Endogenous metabolite 500 - Internal Server Error | MedChemExpress

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