48

Daclatasvir dihydrochloride

48 Publications Verification

Cat. No.: HY-10465

CAS No.: 1009119-65-6

Purity: 99.68%

Synonyms: BMS-790052 dihydrochloride; EBP 883 dihydrochloride

Target:

HCV

Research Areas:

Infection

Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) is a potent and orally active HCV NS5A protein inhibitor with EC₅₀s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir dihydrochloride is also an organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC₅₀s of 1.5 μM and 3.27 μM, respectively .

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48

Daclatasvir

48 Publications Verification

Cat. No.: HY-10466

CAS No.: 1009119-64-5

Purity: 98.68%

Synonyms: BMS-790052; EBP 883

Target:

HCV

Research Areas:

Infection

Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC₅₀s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC₅₀s of 1.5 µM and 3.27 µM, respectively .

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44

Telaprevir

44 Cited Publications

Cat. No.: HY-10235

CAS No.: 402957-28-2

Purity: 99.54%

Synonyms: VX-950

Target:

HCV Protease HCV SARS-CoV

Research Areas:

Infection

Telaprevir (VX-950) is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease, the steady-state inhibitory constant (K_i) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide . Telaprevir inhibits SARS-CoV-2 3CL ^pro activity .

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36

Fenofibrate

36 Cited Publications

Cat. No.: HY-17356

CAS No.: 49562-28-9

Target:

PPAR Cytochrome P450 Autophagy

Research Areas:

Cardiovascular Disease Cancer

Fenofibrate is a selective PPARα agonist with an EC₅₀ of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC₅₀s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.

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33

Clopidogrel hydrogen sulfate

33 Cited Publications

Cat. No.: HY-17459

CAS No.: 120202-66-6

Synonyms: (S)-(+)-Clopidogrel bisulfate; (S)-(+)-Clopidogrel hydrogen sulfate

Target:

Cytochrome P450 P2Y Receptor

Research Areas:

Cardiovascular Disease Cancer

Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC₅₀s of 18.2 nM and 524 nM, respectively . Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation ．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor .

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31

Ledipasvir

31 Cited Publications

Cat. No.: HY-15602

CAS No.: 1256388-51-8

Purity: 99.69%

Synonyms: GS-5885

Target:

HCV SARS-CoV

Research Areas:

Infection

Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC₅₀s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 1.62 μM .

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30

Grazoprevir

30 Cited Publications

Cat. No.: HY-15298

CAS No.: 1350514-68-9

Purity: 99.99%

Synonyms: MK-5172

Target:

HCV Protease HCV SARS-CoV

Research Areas:

Infection

Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir inhibits SARS-CoV-2 3CL ^pro activity .

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30

Grazoprevir potassium salt

30 Cited Publications

Cat. No.: HY-15298A

CAS No.: 1206524-86-8

Purity: 99.63%

Synonyms: MK-5172 potassium salt

Target:

HCV HCV Protease SARS-CoV

Research Areas:

Infection

Grazoprevir potassium salt (MK-5172 potassium salt) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir potassium salt inhibits SARS-CoV-2 3CL ^pro activity .

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30

Grazoprevir hydrate

30 Cited Publications

Cat. No.: HY-15298B

CAS No.: 1350462-55-3

Purity: 99.99%

Synonyms: MK-5172 hydrate

Target:

HCV HCV Protease SARS-CoV

Research Areas:

Infection

Grazoprevir hydrate (MK-5172 hydrate) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir hydrate inhibits SARS-CoV-2 3CL ^pro activity .

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20

Danoprevir

20 Cited Publications

Cat. No.: HY-10238

CAS No.: 850876-88-9

Purity: 99.67%

Synonyms: ITMN-191; R7227; RO5190591; RG7227

Target:

HCV Protease HCV SARS-CoV

Research Areas:

Infection

Danoprevir (ITMN-191) is an orally active NS3/4A protease inhibitor for hepatitis C virus (HCV) with an IC₅₀ of 0.29 nM and is selective for NS3/4A over a panel of 53 proteases (IC₅₀ higher than 10 μM). Danoprevir (ITMN-191) inhibits HCV genotypes 1a, 1b, 4, 5, and 6 (IC₅₀s=0.2-0.4 nM) as well as 2b and 3a (IC₅₀s=1.6, 3.5 nM) . Danoprevir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 0.05 μM .

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15

Dasabuvir

15 Cited Publications

Cat. No.: HY-13998

CAS No.: 1132935-63-7

Purity: 98.17%

Synonyms: ABT-333

Target:

HCV DNA/RNA Synthesis

Research Areas:

Infection

Dasabuvir (ABT-333) is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir inhibits RNA-dependent RNA polymerase encoded by the HCV NS5B gene. Dasabuvir inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC₅₀ values of 7.7 and 1.8 nM, respectively .

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14

Myriocin

14 Cited Publications

Cat. No.: HY-N6798

CAS No.: 35891-70-4

Synonyms: Thermozymocidin; ISP-I

Category:

Infection Microorganisms Ketones, Aldehydes, Acids Disease Research Fields

Target:

HCV Antibiotic

Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC₅₀ of 3.5 μg/mL for inhibiting HCV infection .

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12

Elbasvir

12 Cited Publications

Cat. No.: HY-15789

CAS No.: 1370468-36-2

Purity: 99.97%

Synonyms: MK-8742

Target:

HCV

Research Areas:

Infection

Elbasvir (MK-8742) is a hepatitis C virus nonstructural protein 5A (HCV NS5A) inhibitor with EC₅₀s of 4, 3 and 3 nM against genotype 1a, 1b, and 2a, respectively.

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11

Omeprazole

11 Cited Publications

Cat. No.: HY-B0113

CAS No.: 73590-58-6

Synonyms: H 16868

Target:

Na+/K+ ATPase Proton Pump Bacterial Cytochrome P450 Apoptosis Autophagy Atg8/LC3 TNF Receptor Interleukin Related

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Omeprazole (H 16868) is an orally active H ⁺,K ⁺-ATPase inhibitor and a proton pump inhibitor. Omeprazole competitively inhibits CYP2C19, CYP3A4, and CYP2C9 activity. Omeprazole inhibits gastric acid secretion and can be used for acid-related gastrointestinal disorders. Omeprazole inhibits pancreatic cancer cell proliferation, induces apoptosis, autophagosome accumulation (elevated LC3-I and LC3-II levels), oxidative stress, and cytogenetic imbalance, modulates lysosomal transport, reduces inflammatory cytokines. Omeprazole alters small intestinal morphology and magnesium absorption, and induces gastric mucosa morphologic changes. Omeprazole also has neuroprotective and antibacterial effects .

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11

Omeprazole sodium

11 Cited Publications

Cat. No.: HY-B0113A

CAS No.: 95510-70-6

Synonyms: H 16868 sodium

Target:

Na+/K+ ATPase Interleukin Related Proton Pump Cytochrome P450 Bacterial Apoptosis Autophagy TNF Receptor Atg8/LC3

Research Areas:

Infection Inflammation/Immunology

Omeprazole (H 16868) sodium is an orally active H ⁺,K ⁺-ATPase inhibitor and a proton pump inhibitor. Omeprazole sodium competitively inhibits CYP2C19, CYP3A4, and CYP2C9 activity. Omeprazole sodium inhibits gastric acid secretion and can be used for acid-related gastrointestinal disorders. Omeprazole sodium inhibits pancreatic cancer cell proliferation, induces apoptosis, autophagosome accumulation (elevated LC3-I and LC3-II levels), oxidative stress, and cytogenetic imbalance, modulates lysosomal transport, reduces inflammatory cytokines. Omeprazole sodium alters small intestinal morphology and magnesium absorption, and induces gastric mucosa morphologic changes. Omeprazole sodium also has neuroprotective and antibacterial effects .

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10

Velpatasvir

10 Cited Publications

Cat. No.: HY-12530

CAS No.: 1377049-84-7

Purity: 99.57%

Synonyms: GS-5816

Target:

HCV SARS-CoV

Research Areas:

Infection Inflammation/Immunology Cancer

Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. Velpatasvir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 2.16 μM .

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9

Ombitasvir

9 Cited Publications

Cat. No.: HY-13997

CAS No.: 1258226-87-7

Purity: 98.59%

Synonyms: ABT-267

Target:

HCV

Research Areas:

Infection

Ombitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC₅₀s of 0.82 to 19.3 pM against HCV genotypes 1 to 5, and 366 pM against genotype 6a.

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7

Stiripentol

7 Cited Publications

Cat. No.: HY-103392

CAS No.: 49763-96-4

Purity: 99.99%

Synonyms: BCX2600

Target:

Cytochrome P450

Research Areas:

Neurological Disease

Stiripentol (STP) is an anticonvulsant agent, which can inhibit N-demethylation of CLB to NCLB mediatated by CYP3A4 (noncompetitively) and CYP2C19 (competitively) with K_i of 1.59±0.07 and 0.516±0.065 μM and IC₅₀ of 1.58 and 3.29 μM, respectively.

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6

Isobavachin

6 Cited Publications

Cat. No.: HY-N0762

CAS No.: 31524-62-6

Category:

Flavonoids Neurological Disease Flavonones Phenols Polyphenols 500 - Internal Server Error | MedChemExpress

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