99

99 Publications Verification

Synonyms: Luteoline; Luteolol; Digitoflavone

Category:

Flavones Plants Other Families Extract Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Microorganisms Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:

Keap1-Nrf2 Apoptosis Autophagy Endogenous Metabolite

Luteolin (Luteoline), a flavanoid compound, is a potent Nrf2 inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

99

Luteolin monohydrate

99 Publications Verification

Cat. No.: HY-W303895

CAS No.: 6113-16-2

Target:

Keap1-Nrf2 Apoptosis Autophagy Endogenous Metabolite

Research Areas:

Others Cancer

Luteolin (monohydrate) is the monohydrate of Luteolin. Luteolin (Luteoline), a flavonoid, is also a potent Nrf2 inhibitor. Luteolin has anti-inflammatory and anticancer properties, induces apoptosis and cell cycle arrest in multiple human cancer cell lines, including non-small lung cancer cells, and inhibits cell metastasis and angiogenesis .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

49

Ganetespib

49 Cited Publications

Cat. No.: HY-15205

CAS No.: 888216-25-9

Purity: 99.94%

Synonyms: STA-9090

Target:

HSP Apoptosis

Research Areas:

Cancer

Ganetespib (STA-9090) is a heat shock protein 90 (HSP90) inhibitor which exhibits potent cytotoxicity in a wide variety of hematological and solid tumor cell lines. Ganetespib has antiangiogenic effects in colorectal cancer mediated through inhibition of HIF-1α and STAT3 .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

39

Temuterkib

39 Cited Publications

Cat. No.: HY-101494

CAS No.: 1951483-29-6

Purity: 99.94%

Synonyms: LY3214996

Target:

ERK

Research Areas:

Cancer

Temuterkib (LY3214996) is a highly selective inhibitor of ERK1 and ERK2, with IC₅₀ of 5 nM for both enzymes in biochemical assays. Temuterkib potently inhibits cellular p-RSK1 in BRAF and RAS mutant cancer cell lines. Temuterkib shows potent antitumor activities in cancer models with MAPK pathway alterations.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

37

iFSP1

37 Cited Publications

Cat. No.: HY-136057

CAS No.: 150651-39-1

Purity: 99.96%

Target:

Ferroptosis Ligands for Target Protein for PROTAC

Research Areas:

Cancer

iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC₅₀ of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A) .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

31

3PO

31 Cited Publications

Cat. No.: HY-19824

CAS No.: 18550-98-6

Target:

Autophagy

Research Areas:

Cancer

3PO is an inhibitor of PFKFB3. 3PO attenuates the proliferation of several cancer cell lines with IC₅₀s of 1.4-24 μmol/L. 3PO suppresses glucose uptake and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD ⁺ and NADH. 3PO can be used for the research of cancer .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

30

Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant

30 Cited Publications

Cat. No.: HY-Y1883

CAS No.: 9002-93-1

Target:

Biochemical Assay Reagents Apoptosis

Research Areas:

Infection Cancer

Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant is a non-denaturing detergent that solubilizes lipid membranes. Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant is commonly used in laboratories and is applied to vaccines at different stages of the manufacturing process. Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant is listed as an excipient in certain vaccines including split virus influenza vaccines. Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant is a nonionic surfactant. Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant induces Apoptosis in prostate and colon cancer cell lines and reduces the infectivity of classic enveloped viruses such as WNV .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

30

Polyethylene glycol mono(4-tert-octylphenyl) ether

30 Cited Publications

Cat. No.: HY-Y1883A

CAS No.: 9002-93-1

Target:

Biochemical Assay Reagents

Research Areas:

Infection Cancer

Polyethylene glycol mono(4-tert-octylphenyl) ether is a non-denaturing detergent that solubilizes lipid membranes. Polyethylene glycol mono(4-tert-octylphenyl) ether is commonly used in laboratories and is applied to vaccines at different stages of the manufacturing process. Polyethylene glycol mono(4-tert-octylphenyl) ether is listed as an excipient in certain vaccines including split virus influenza vaccines. Polyethylene glycol mono(4-tert-octylphenyl) ether is a nonionic surfactant. Polyethylene glycol mono(4-tert-octylphenyl) ether induces Apoptosis in prostate and colon cancer cell lines and reduces the infectivity of classic enveloped viruses such as WNV .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

23

CBR-5884

23 Cited Publications

Cat. No.: HY-100012

CAS No.: 681159-27-3

Purity: 98.73%

Target:

Phosphoglycerate Dehydrogenase (PHGDH)

Research Areas:

Cancer

CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC₅₀ of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

23

Aldoxorubicin

23 Cited Publications

Cat. No.: HY-16261

CAS No.: 1361644-26-9

Synonyms: INNO-206; DOXO-EMCH

Target:

Topoisomerase ADC Payloads

Research Areas:

Cancer

Aldoxorubicin (INNO-206) is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), which is released from albumin under acidic conditions. Aldoxorubicin (INNO-206) has potent antitumor activities in various cancer cell lines and in murine tumor models.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

21

Fumarate hydratase-IN-1

21 Cited Publications

Cat. No.: HY-100004

CAS No.: 1644060-37-6

Purity: 99.14%

Target:

Mitochondrial Metabolism

Research Areas:

Cancer

Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor. Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC₅₀ of 2.2 μM .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

21

BAY-3827

21 Cited Publications

Cat. No.: HY-112083

CAS No.: 2377576-35-5

Purity: 99.66%

Target:

AMPK

Research Areas:

Cancer

BAY-3827, a chemical probe, is a potent and selective AMPK inhibitor with IC₅₀ values of 1.4 nM at low (10 μM ATP concentration) and 15 nM at high (2 mM ATP concentration). BAY-3827 shows over 500-fold selectivity for most of the 331 kinases. BAY-3827 prevents phosphorylation of acetyl-CoA carboxylase 1 and shows strongest anti-proliferative activity in androgen-dependent prostate cancer cell lines .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

20

Elacestrant

20 Cited Publications

Cat. No.: HY-19822

CAS No.: 722533-56-4

Synonyms: RAD1901

Target:

Estrogen Receptor/ERR

Research Areas:

Cancer

Elacestrant (RAD1901) is an orally available and selective estrogen receptor degrader (SERD) with IC₅₀s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant also can inhibit growth of ER ⁺ breast cancer cell lines in vitro and in vivo .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

20

Elacestrant dihydrochloride

20 Cited Publications

Cat. No.: HY-19822A

CAS No.: 1349723-93-8

Synonyms: RAD1901 dihydrochloride

Target:

Estrogen Receptor/ERR

Research Areas:

Cancer

Elacestrant (RAD1901) dihydrochloride is an orally available and selective estrogen receptor degrader (SERD) with IC₅₀s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant dihydrochloride also can inhibit growth of ER ⁺ breast cancer cell lines in vitro and in vivo .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

18

MKT-077

18 Cited Publications

Cat. No.: HY-15096

CAS No.: 147366-41-4

Purity: ≥98.0%

Synonyms: FJ-776

MKT-077 (FJ-776), a highly water-soluble mitochondrial dye, has significant antitumor activity . MKT-077 exhibits low cytotoxicity, and inhibits broad-spectrum human cancer cell lines (colon cancer, breast cancer, pancreatic cancer). MKT-077 inhibits the growth of tumor in nude mice enograft tumor model. Ex/Em=488/543 nm .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

17

MPP hydrochloride

17 Cited Publications

Cat. No.: HY-103454B

CAS No.: 2863676-89-3

Purity: 99.28%

Target:

Estrogen Receptor/ERR Apoptosis

Research Areas:

Endocrinology Cancer

MPP hydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP hydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP hydrochloride reverses the the positive effects of beta-estradiol. MPP hydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

17

MPP dihydrochloride

17 Cited Publications

Cat. No.: HY-103454

CAS No.: 911295-24-4

Purity: 99.54%

Target:

Estrogen Receptor/ERR Apoptosis

Research Areas:

Endocrinology Cancer

MPP dihydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP dihydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP dihydrochloride reverses the positive effects of beta-estradiol. MPP dihydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo .

Compare

loading...