29

Ebselen

29 Publications Verification

Cat. No.: HY-13750

CAS No.: 60940-34-3

Purity: 99.58%

Synonyms: SPI-1005; PZ-51; CCG-39161

Target:

Calcium Channel Virus Protease HIV Phosphatase

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Ebselen (SPI-1005), a glutathione peroxidase mimetic, is a potent voltage-dependent calcium channel (VDCC) blocker . Ebselen potently inhibits M ^pro (IC₅₀=0.67 μM) and COVID-19 virus (EC₅₀=4.67 μM) .Ebselen is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity .

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22

Lenacapavir

22 Cited Publications

Cat. No.: HY-111964

CAS No.: 2189684-44-2

Purity: 98.44%

Synonyms: GS-6207

Target:

HIV

Research Areas:

Infection

Lenacapavir (GS-6207) is an HIV-1 capsid inhibitor. Lenacapavir binds to the interface between capsid hexamers and CA monomers, disrupts capsid assembly and viral maturation, inhibits nuclear translocation of HIV-1 DNA, interferes with CA-mediated protein-protein interactions, reduces the formation of 2-LTR circles and pre-integration proviruses, induces aberrant capsids, and decreases the production of mature HIV-1. Lenacapavir exhibits activity against a variety of HIV-1 subtypes and clinical isolates. Lenacapavir is applicable to research related to human immunodeficiency virus type 1 (HIV-1) infection .

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22

Lenacapavir sodium

22 Cited Publications

Cat. No.: HY-111964A

CAS No.: 2283356-12-5

Synonyms: GS-6207 sodium

Target:

HIV

Research Areas:

Infection

Lenacapavir (GS-6207) sodium is an HIV-1 capsid inhibitor. Lenacapavir sodium binds to the interface between capsid hexamers and CA monomers, disrupts capsid assembly and viral maturation, inhibits nuclear translocation of HIV-1 DNA, interferes with CA-mediated protein-protein interactions, reduces the formation of 2-LTR circles and pre-integration proviruses, induces aberrant capsids, and decreases the production of mature HIV-1. Lenacapavir sodium exhibits activity against a variety of HIV-1 subtypes and clinical isolates. Lenacapavir sodium is applicable to research related to human immunodeficiency virus type 1 (HIV-1) infection .

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10

Cetylpyridinium chloride

10 Cited Publications

Cat. No.: HY-B1464

CAS No.: 123-03-5

Target:

Environmental Pollutants Bacterial HBV

Research Areas:

Infection Inflammation/Immunology

Cetylpyridinium chloride, a cationic quaternary ammonium compound, is an anti-bacterial agent with broad-spectrum activity. Cetylpyridinium chloride is an effective anti-HBV capsid assembly inhibitor with an IC₅₀ of 2.5 μM. Cetylpyridinium chloride is used in pesticides and various types of mouthwashes, and other personal care products .

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6

PF-3450074

6 Cited Publications

Cat. No.: HY-120072

CAS No.: 1352879-65-2

Purity: 98.89%

Synonyms: PF-74

Target:

HIV

Research Areas:

Infection

PF-3450074 (PF-74) is a specifical inhibitor of HIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC₅₀=8-640 nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle . CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153.

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5

Pocapavir

5 Cited Publications

Cat. No.: HY-104074

CAS No.: 146949-21-5

Purity: 99.59%

Synonyms: SCH-48973; V-073

Target:

Enterovirus

Research Areas:

Infection

Pocapavir (SCH-48973) is an orally active capsid inhibitor. Pocapavir prevents virion uncoating upon entry into the cell. Pocapavir has antiviral activity against polioviruses. Pocapavir also inhibits enterovirus infections .

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4

Vapendavir diphosphate

4 Cited Publications

Cat. No.: HY-106254A

CAS No.: 1198151-75-5

Purity: 98.75%

Synonyms: BTA798 diphosphate

Target:

Enterovirus

Research Areas:

Infection Inflammation/Immunology

Vapendavir diphosphate (BTA798 diphosphate) is a potent enteroviral capsid binder (CB). Vapendavir diphosphate (BTA798 diphosphate) possesses potent antiviral activity for enterovirus 71 (EV71) replication, with EC₅₀ values of 0.5-1.4 μM in different EV71 strains .

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4

Vapendavir

4 Cited Publications

Cat. No.: HY-106254

CAS No.: 439085-51-5

Synonyms: BTA798

Target:

Enterovirus

Research Areas:

Infection

Vapendavir (BTA798) is a potent enteroviral capsid binder (CB). Vapendavir (BTA798) possesses potent antiviral activity for enterovirus 71 (EV71) replication, with EC₅₀ values of 0.5-1.4 μM in different EV71 strains .

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3

Bersacapavir

3 Cited Publications

Cat. No.: HY-109168

CAS No.: 1638266-40-6

Purity: 99.24%

Synonyms: JNJ-6379; JNJ-56136379

Target:

HBV DNA/RNA Synthesis

Research Areas:

Infection

Bersacapavir (JNJ-6379) is an HBV capsid assembly modulator. Bersacapavir exerts a dual mechanism of action against both early and late stages of HBV infection by forming complete genome-free empty capsids and inhibiting de novo synthesis of cccDNA. Bersacapavir inhibits HBV replication. Bersacapavir can be used in the research of hepatitis B .

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3

NVR 3-778

3 Cited Publications

Cat. No.: HY-124600

CAS No.: 1445790-55-5

Purity: 99.88%

Target:

HBV

Research Areas:

Infection

NVR 3-778 is a first-in-Class and oral bioavailable HBV CAM (capsid assembly modulator) belonging to the SBA (sulfamoylbenzamide) class, with anti-HBV activity .

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3

AB-423

3 Cited Publications

Cat. No.: HY-112142

CAS No.: 1572510-80-5

Purity: 99.31%

Synonyms: (R)-DVR-23

Target:

HBV

Research Areas:

Infection

AB-423 is an inhibitor of HBV capsid assembly, and potent inhibits HBV replication with EC₅₀/EC₉₀ of 0.08-0.27 μM/0.33-1.32 μM in cells.

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2

JNJ-632

2 Cited Publications

Cat. No.: HY-112564

CAS No.: 1572510-42-9

Purity: 99.94%

Target:

HBV

Research Areas:

Infection

JNJ-632 is a hepatitis B virus (HBV) capsid assembly modulator (CAM).

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2

CA inhibitor 1

2 Cited Publications

Cat. No.: HY-124594

CAS No.: 2189684-45-3

Purity: 99.77%

Synonyms: GS-6207 analog

Target:

HIV

Research Areas:

Infection

CA inhibitor 1 (GS-6207 analog) is a potent HIV capsid inhibitor for HIV inhibition . CA inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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