17

DMH-1

17 Publications Verification

Cat. No.: HY-12273

CAS No.: 1206711-16-1

Purity: 99.93%

Target:

TGF-β Receptor Organoid Microtubule/Tubulin

Research Areas:

Cardiovascular Disease Neurological Disease

DMH-1 is a selective BMP inhibitor. DMH-1 upregulates the expression of SOX1. DMH-1 increases cardiomyocyte progenitor cells and promotes the differentiation of mouse embryonic stem cells into cardiomyocytes. DMH-1 induces the differentiation of hiPSC-derived neural progenitor cells into β3-tubulin-positive neurons .

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14

Conivaptan hydrochloride

14 Cited Publications

Cat. No.: HY-18347A

CAS No.: 168626-94-6

Synonyms: YM 087

Target:

Vasopressin Receptor Cytochrome P450

Conivaptan hydrochloride (YM 087) is an orally active dual vasopressin V_1a/V₂ receptor antagonist with K_i values of 0.48 nM and 3.04 nM for vasopressin V_1a receptor and V₂ receptor, respectively. Conivaptan hydrochloride competitively and reversibly blocks vasopressin-mediated antidiuresis, vasoconstriction, and cellular hypertrophy, while inhibiting CYP3A4. Conivaptan hydrochloride inhibits vasopressin-induced intracellular calcium, cAMP, and mitogen-activated kinase activation in vascular smooth muscle cells and cardiomyocytes. Conivaptan hydrochloride induces water diuresis while improving hemodynamics in heart failure models, reducing left ventricular end-diastolic pressure, vascular resistance, and organ weight. Conivaptan hydrochloride is used for research on hyponatremia and congestive heart failure .

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10

Uridine 5′-diphosphoglucose disodium

10 Cited Publications

Cat. No.: HY-N7032

CAS No.: 28053-08-9

Synonyms: UDP-D-Glucose disodium

Category:

Natural Products Endogenous metabolite

Target:

Endogenous Metabolite P2Y Receptor

Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue.

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5

KY02111

5 Cited Publications

Cat. No.: HY-13815

CAS No.: 1118807-13-8

Purity: 99.23%

Target:

Wnt

Research Areas:

Cardiovascular Disease

KY02111 is a canonical WNT signaling (β-catenin) inhibitor which promotes differentiation of hPSCs to cardiomyocytes. KY02111 can be used for the research of human cardiomyocyte regeneration .

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5

DMX-5804

5 Cited Publications

Cat. No.: HY-111754

CAS No.: 2306178-56-1

Purity: 99.83%

Target:

MAP4K

Research Areas:

Cardiovascular Disease

DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC₅₀ of 3 nM, a pIC₅₀ of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC₅₀, 8.18), and TNIK/MAP4K7 (pIC₅₀, 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice .

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4

Ostarine

4 Cited Publications

Cat. No.: HY-13273

CAS No.: 841205-47-8

Purity: 99.90%

Synonyms: MK-2866; GTX-024; Enobosarm

Target:

Androgen Receptor

Research Areas:

Others Cancer

Ostarine (MK-2866) is a selective androgen receptor modulator (SARMs) that regulates cardiomyocyte function, improves bone healing, regulates uterine function, and influences muscle tissue metabolism .

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4

4'-O-Methylbavachalcone

4 Cited Publications

Cat. No.: HY-N1910

CAS No.: 20784-60-5

Category:

Infection Flavonoids Chalcones Phenols Polyphenols 500 - Internal Server Error | MedChemExpress

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