750 Results for "

Caspase3

" in MedChemExpress (MCE) Product Catalog:

Products (750)

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881

Z-VAD-FMK

881 Publications Verification

Cat. No.: HY-16658B

CAS No.: 161401-82-7

Synonyms: Z-VAD(OH)-FMK

Target:

Caspase Apoptosis RIP kinase Glutathione Peroxidase Reactive Oxygen Species (ROS)

Research Areas:

Inflammation/Immunology Cancer

Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis ^[3] .

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143

Z-DEVD-FMK

143 Cited Publications

Cat. No.: HY-12466

CAS No.: 210344-95-9

Purity: ≥98.0%

Target:

Caspase

Research Areas:

Cancer

Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor with an IC₅₀ of 18 μM .

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114

Tauroursodeoxycholate

114 Cited Publications

Cat. No.: HY-19696

CAS No.: 14605-22-2

Synonyms: Tauroursodeoxycholic acid; TUDCA; UR 906

Category:

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:

ERK Caspase Endogenous Metabolite Apoptosis

Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an orally active endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK ^[3].

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114

Tauroursodeoxycholate sodium

114 Cited Publications

Cat. No.: HY-19696A

CAS No.: 35807-85-3

Synonyms: Tauroursodeoxycholic acid sodium; TUDCA sodium; UR 906 sodium

Category:

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:

ERK Caspase Apoptosis Endogenous Metabolite

Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

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114

Tauroursodeoxycholate dihydrate

114 Cited Publications

Cat. No.: HY-19696B

CAS No.: 117609-50-4

Synonyms: Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate

Category:

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:

Caspase Apoptosis Endogenous Metabolite IRE1 NF-κB JNK Reactive Oxygen Species (ROS) Akt

Tauroursodeoxycholate dehydrate is an orally active taurine conjugate of Ursodeoxycholic acid (HY-13771). Tauroursodeoxycholate dehydrate inhibits caspase-3/7, Apoptosis, IRE1α/TRAF2/NF-κB, prevents JNK phosphorylation, inhibits ROS generation, and activates Akt signaling. Tauroursodeoxycholate dehydrate prevents cataract formation, reduces renal tubular damage in type 2 diabetic mice, reduces I/R injury in liver, and inhibits intestinal inflammation and barrier disruption in nonalcoholic fatty liver disease ^[3] .

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Emricasan

63 Cited Publications

Cat. No.: HY-10396

CAS No.: 254750-02-2

Purity: 99.81%

Synonyms: PF 03491390; IDN-6556

Target:

Caspase Flavivirus

Research Areas:

Infection Neurological Disease Cancer

Emricasan (PF 03491390) is an orally active and irreversible pan-caspase inhibitor. Emricasan inhibits Zika virus (ZIKV)-induced increases in caspase-3 activity and protected human cortical neural progenitors .

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Idasanutlin

52 Cited Publications

Cat. No.: HY-15676

CAS No.: 1229705-06-9

Purity: 99.93%

Synonyms: RG7388

Target:

MDM-2/p53 E1/E2/E3 Enzyme Apoptosis Pyroptosis Reactive Oxygen Species (ROS) Caspase

Research Areas:

Neurological Disease Cancer

Idasanutlin (RG7388) is an orally bioavailable MDM2 inhibitor with an IC₅₀ of 6 nM. Idasanutlin disrupts MDM2-p53 binding, stabilizes and activates p53, triggering cell cycle arrest, apoptosis, and reduced cancer cell viability. Idasanutlin reduces EGFR protein expression and phosphorylation, suppresses downstream SHP2, MEK1/2, ERK1/2, AKT, mTOR, p70(S6K1), and S6 signaling. Idasanutlin induces mitochondrial ROS production, drives p38 MAPK phosphorylation, upregulates NOXA, and mediates caspase-3-dependent apoptosis and gasdermin E-mediated pyroptosis. Idasanutlin can be used for the research of TP53-mutant non-small cell lung cancer, T-cell acute lymphoblastic leukemia, colorectal carcinoma, melanoma, diffuse large B-cell lymphoma, mantle cell lymphoma, non-Hodgkin lymphoma, severe fever with thrombocytopenia syndrome, neuroblastoma, acute lymphoblastic leukemia, relapsed or refractory acute myeloid leukemia, osteosarcoma, solid tumors, and hematological tumors ^[3] .

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Ac-DEVD-CHO

50 Cited Publications

Cat. No.: HY-P1001

CAS No.: 169332-60-9

Target:

Caspase

Research Areas:

Cancer

Ac-DEVD-CHO is a Caspase-3 inhibitor with a K_i value of 230 pM.

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ARV-825

37 Cited Publications

Cat. No.: HY-16954

CAS No.: 1818885-28-7

Target:

PROTACs Epigenetic Reader Domain c-Myc Polo-like Kinase (PLK) CDK JAK STAT Pim Bcl-2 Family PAK Wnt β-catenin Caspase PARP Apoptosis Reactive Oxygen Species (ROS)

Research Areas:

Neurological Disease Cancer

ARV-825 is a BET protein PROTAC degrader that recruits cereblon, and it targets BRD2, BRD3, and BRD4 for degradation via the ubiquitin-proteasome pathway. ARV-825 downregulates c-MYC, PLK1, MYCN, CDK4/6, JAK2, pSTAT3/5, PIM1, and Bcl-xL, upregulates p21 and p27, and modulates H3K27Ac-mediated transcription, the G2/M checkpoint, the Wnt/β-catenin pathway, and amino acid transport pathways. ARV-825 induces G1 phase cell cycle arrest, caspase 3/PARP-mediated apoptosis, DNA damage, and reactive oxygen species (ROS) production, reduces mitochondrial respiration, and simultaneously inhibits cell proliferation, clonogenic growth, and cell migration. ARV-825 is used in research on gastric cancer, leukemia, neuroblastoma, and cholangiocarcinoma ^[3] .

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Beta-Sitosterol (purity>80%)

27 Cited Publications

Cat. No.: HY-N0171

CAS No.: 83-46-5

Category:

Endogenous metabolite

Target:

Apoptosis Endogenous Metabolite

Beta-Sitosterol (purity≥80%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc ^[3] .

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Beta-Sitosterol (purity>98%)

27 Cited Publications

Cat. No.: HY-N0171A

CAS No.: 83-46-5

Synonyms: β-Sitosterol (purity>98%); 22,23-Dihydrostigmasterol (purity>98%)

Category:

Steroids

Target:

Bacterial Apoptosis Reactive Oxygen Species (ROS) MDM-2/p53 Caspase PARP MMP Bcl-2 Family HIF/HIF Prolyl-Hydroxylase TNF Receptor Interleukin Related NF-κB mTOR Lactate Dehydrogenase CDK Glutathione Peroxidase SOD

Beta-Sitosterol (purity>98%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc ^[3] .

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