530

BAY 11-7082

530 Publications Verification

Cat. No.: HY-13453

CAS No.: 19542-67-7

Purity: 99.98%

Synonyms: BAY 11-7821

Target:

IKK Deubiquitinase Autophagy Apoptosis NF-κB

Research Areas:

Inflammation/Immunology Cancer

BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC₅₀=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

12

Lifitegrast

12 Cited Publications

Cat. No.: HY-19344

CAS No.: 1025967-78-5

Synonyms: SAR 1118; SHP-606

Target:

Integrin

Research Areas:

Inflammation/Immunology

Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC₅₀ of 2.98 nM. Lifitegrast can be used for researching dry eye disease .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

12

Lifitegrast sodium

12 Cited Publications

Cat. No.: HY-19344A

CAS No.: 1119276-80-0

Synonyms: SAR 1118 sodium; SHP-606 sodium

Target:

Integrin

Research Areas:

Inflammation/Immunology

Lifitegrast (SAR 1118) sodium is a potent integrin antagonist. Lifitegrast sodium blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast sodium inhibits Jurkat T cell attachment to ICAM-1 with an IC₅₀ of 2.98 nM. Lifitegrast sodium can be used for researching dry eye disease .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

5

Natalizumab

5 Cited Publications

Cat. No.: HY-108831

CAS No.: 189261-10-7

Purity: 99.10%

Natalizumab (AN100226; BG00002) is a humanized monoclonal IgG4 antibody inhibitor that selectively targets α4 integrin (CD49d). It blocks the interaction of integrins such as α4β1 (VLA-4) with vascular cell adhesion molecule VCAM-1, intercellular adhesion molecule ICAM-1, and fibronectin by competitively binding to the α4 subunit. Natalizumab inhibits the adhesion, retention, and transendothelial migration of immune cells (such as CD4 ⁺ T cells), reducing the infiltration of inflammatory cells into the central nervous system or lesion sites, thus exerting anti-inflammatory and immunomodulatory activity. Natalizumab is used in the study of relapsing-remitting multiple sclerosis (RRMS) and also has applications in the study of autoimmune or inflammation-related diseases such as Crohn's disease, B-cell lymphoma, and non-infectious uveitis. Natalizumab can also prevent lymphocytes from entering the central nervous system, thereby preventing acute demyelinating relapses .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

5

Natalizumab (Anti-CD49d)

5 Cited Publications

Cat. No.: HY-108831A

CAS No.: 189261-10-7

Purity: 98.72%

Synonyms: AN100226; BG00002

Natalizumab (Anti-CD49d) (AN100226; BG00002) Solution is a humanized monoclonal IgG4 antibody inhibitor that selectively targets α4 integrin (CD49d), blocking the interaction of integrins such as α4β1 (VLA-4) with vascular cell adhesion molecule VCAM-1, intercellular adhesion molecule ICAM-1, and fibronectin by competitively binding to the α4 subunit. Natalizumab solution inhibits the adhesion, retention, and transendothelial migration of immune cells (such as CD4 ⁺ T cells), reducing the infiltration of inflammatory cells into the central nervous system or lesion sites, thereby exerting anti-inflammatory and immunomodulatory activity. Natalizumab (Anti-CD49d) solution is used in the study of relapsing-remitting multiple sclerosis (RRMS) and is also applied in the research of autoimmune or inflammation-related diseases such as Crohn's disease, B-cell lymphoma, and non-infectious uveitis. Natalizumab (Anti-CD49d) can also prevent lymphocytes from entering the central nervous system, thus preventing acute demyelinating relapses .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

4

CD31 Antibody (YA541)

4 Cited Publications

Cat. No.: HY-P80447

Synonyms: adhesion molecule antibody; CD31 antibody; CD31 antigen antibody; CD31 EndoCAM antibody; EndoCAM antibody; FLJ34100 antibody; FLJ58394 antibody; GPIIA antibody; GPIIA' antibody; PECA1 antibody; PECA1_HUMAN antibody; Pecam 1 antibody; PECAM 1 CD31 EndoCAM antibody; PECAM antibody; PECAM-1 antibody; Pecam1 antibody; Platelet and endothelial Cell adhesion molecule 1 antibody; Platelet endothelial Cell adhesion molecule antibody; Platelet/endothelial Cell adhesion molecule 1 antibody;

Host:

Rabbit

Application:

WB, IHC-P, ICC/IF, IP, FC

Reactivity:

Human

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

4

Rhamnocitrin

4 Cited Publications

Cat. No.: HY-N1353

CAS No.: 569-92-6

Category:

Cardiovascular Disease Flavonols Flavonoids Phenols Polyphenols Plants Other Families Extract Disease Research Fields

Target:

Free Radical Scavengers p38 MAPK

Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3 and MAPK pathways and can scavenge DPPH (IC₅₀=28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6, IL-8) and adhesion molecules (such as ICAM-1, VCAM-1). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells) .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

3

Chymotrypsin

3 Cited Publications

Cat. No.: HY-108910

CAS No.: 9004-07-3

Synonyms: EC 3.4.21.1; Chymotrypsin A

Chymotrypsin (EC 3.4.21.1; Chymotrypsin A) is an orally effective inhibitor targeting molecules such as TLR4, NF-κB, MMP-1, TNF-α, IL-1β, and IL-6. Chymotrypsin downregulates the TLR4/NF-κB signaling pathway, inhibiting the release of inflammatory factors, reducing cell infiltration and tissue damage. It also reduces the expression of tumor cell adhesion molecules (such as CD44 and CD54) and can be specifically detected by fluorescent probes (such as NBD-3). Chymotrypsin has anti-inflammatory, hepatoprotective, joint damage-reducing, liver protection against lipotoxicity, and anti-tumor metastasis functions. It can be used in research on diseases such as rheumatoid arthritis, non-alcoholic fatty liver disease, and melanoma metastasis. Chymotrypsin can be used in studies of inflammation, edema, and expectoration .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

3

Chymotrypsin (MS grade)

3 Cited Publications

Cat. No.: HY-108910A

CAS No.: 9004-07-3

Synonyms: EC 3.4.21.1 (MS grade); Chymotrypsin A (MS grade)

Target:

Toll-like Receptor (TLR) NF-κB MMP

Research Areas:

Inflammation/Immunology

Chymotrypsin (EC 3.4.21.1; Chymotrypsin A) (MS grade) is an orally effective inhibitor targeting molecules such as TLR4, NF-κB, MMP-1, TNF-α, IL-1β, and IL-6. Chymotrypsin (MS grade) downregulates the TLR4/NF-κB signaling pathway, inhibits the release of inflammatory factors, reduces cell infiltration and tissue damage, and also reduces the expression of tumor cell adhesion molecules (such as CD44 and CD54). It can also be specifically detected by fluorescent probes (such as NBD-3). Chymotrypsin (MS grade) has anti-inflammatory, hepatoprotective, joint damage-reducing, liver protection against lipotoxicity, and anti-tumor metastasis functions, and can be used in the research of diseases such as rheumatoid arthritis, non-alcoholic fatty liver disease, and melanoma metastasis. Chymotrypsin (MS grade) can be used in studies of inflammation, edema, and expectoration .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

CEACAM5 Protein, Human (HEK293, His)

2 Cited Publications

Cat. No.: HY-P70675

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: CEACAM5; Cell adhesion molecule CEACAM5; Prev. CEA; Meconium Antigen 100; Carcinoembryonic Antigen-Related Cell adhesion molecule 5; Carcinoembryonic Antigen-Related Cell adhesion molecule 5 Isoform 5D; CD66e; Carcinoembryonic Antigen-Related Cell Adhesio

Species:

Human

Source:

HEK293

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

Tinurilimab

2 Cited Publications

Cat. No.: HY-P99051

CAS No.: 2226224-30-0

Synonyms: BAY 1834942

Tinurilimab (Bay 1834942) is an anti-CEACAM6 (carcinoembryonic antigen-related cell adhesion molecule 6) humanized IgG2 monoclonal antibody. CEACAM6 is an immune checkpoint regulator suppressing the activity of effector T-cells against tumors. Tinurilimab shows an increased tumor cell killing effect in the tumor-cell/T-cell co-culture system .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

L1CAM Protein, Human (HEK293, His, solution)

2 Cited Publications

Cat. No.: HY-P74791

Purity: ≥ 90%, as determined by reducing SDS-PAGE.

Synonyms: L1CAM; NCAM-L1; Prev. MIC5; CD171; Prev. HSAS1; Antigen Identified By Monoclonal Antibody R1; Prev. HSAS; N-CAM-L1; Prev. MASA; CD171 Antigen; Prev. SPG1; N-CAML1; Prev. S10; HYCX; Neural Cell adhesion molecule L1; L1 Cell adhesion molecule; CAML1

Species:

Human

Source:

HEK293

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

CD44 Antibody (YA6155)

2 Cited Publications

Cat. No.: HY-P86463

Synonyms: LHR antibody; BA-1 antibody; CD 44 antibody; CD44 antibody; CD44 antigen antibody; CD44 molecule; Indian blood group; antibody; CD44 molecule antibody; CD44_HUMAN antibody; CDw44 antibody; CDW44 antigen antibody; Cell surface glycoprotein CD44 antibody; chondroitin sulfate proteoglycan 8 antibody; CSPG8 antibody; ECMR-III antibody; Epican antibody; ExtraCellular matrix receptor III antibody; GP90 lymphocyte homing/adhesion receptor antibody

Host:

Rabbit

Application:

WB, IHC-P, ICC/IF, IP, ELISA

Reactivity:

Human, Mouse, Rat

Compare

loading...