1229 Results for "

Cell death

" in MedChemExpress (MCE) Product Catalog:

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1851

Ferrostatin-1

1851 Publications Verification

Cat. No.: HY-100579

CAS No.: 347174-05-4

Purity: 99.71%

Synonyms: Fer-1

Target:

Ferroptosis Fungal

Research Areas:

Cancer

Ferrostatin-1 (Fer-1), a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC₅₀=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Ferrostatin-1 exhibits antifungal activity .

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601

RSL3

601 Cited Publications

Cat. No.: HY-100218A

CAS No.: 1219810-16-8

Purity: 99.90%

Synonyms: (1S,3R)-RSL3

Target:

p62 Glutathione Peroxidase Ferroptosis Reactive Oxygen Species (ROS)

Research Areas:

Cancer

RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells .

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