219 Results for "

Colony formation

" in MedChemExpress (MCE) Product Catalog:

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LDC1267

10 Publications Verification

Cat. No.: HY-12494

CAS No.: 1361030-48-9

Purity: 99.64%

Target:

TAM Receptor FLT3

Research Areas:

Neurological Disease Cancer

LDC1267 is a AXL/TAM/FLT3 inhibitor with IC₅₀ values of 42 nM, 130 nM, and 63 nM against AXL, MERTK, and TYRO3, respectively. LDC1267 blocks GAS6-induced AXL phosphorylation and the downstream AKT/ERK1/2 signaling pathway. LDC1267 inhibits cancer cell proliferation, colony formation, and glioblastoma cell invasion, without causing obvious impairment of cytotoxic autophagic flux. LDC1267 exerts a synergistic effect when used in combination with Imatinib (HY-15463) in chronic myeloid leukemia models. LDC1267 can be widely applied in studies related to glioblastoma and chronic myeloid leukemia .

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SC66

5 Cited Publications

Cat. No.: HY-19832

CAS No.: 871361-88-5

Target:

MOFs Akt Apoptosis

Research Areas:

Cancer

SC66 is an Akt inhibitor, reduces cell viability in a dose- and time-dependent manner, inhibits colony formation and induces apoptosis in hepatocellular carcinoma (HCC) cells.

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Bimiralisib

5 Cited Publications

Cat. No.: HY-12868

CAS No.: 1225037-39-7

Purity: 98.62%

Synonyms: PQR309

Target:

PI3K mTOR Apoptosis

Research Areas:

Cancer

Bimiralisib (PQR309) is an orally active, blood-brain barrier-penetrant PI3K/mTOR inhibitor with in vitro antiproliferative activity and in vivo antitumor activity. Bimiralisib induces G1 cell cycle arrest, apoptosis and cell death in cancer cells, while inhibiting cancer cell proliferation, migration, invasion, colony formation and spheroid generation. Bimiralisib upregulates the expression of E2F4. The combination of Bimiralisib with venetoclax enhances therapeutic efficacy in acute myeloid leukemia models. Bimiralisib can be used in cancer-related research .

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Estrone sulfate potassium

3 Cited Publications

Cat. No.: HY-113293A

CAS No.: 1240-04-6

Purity: 99.45%

Category:

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:

Endogenous Metabolite Estrogen Receptor/ERR

Estrone sulfate potassium is an inactive endogenous estrogen that can be converted into Estrone (HY-B0234) and Estradiol (HY-B0141). Estrone sulfate potassium is also a substrate of the OATP1B3 transporter. Estrone sulfate potassium can be converted into Estrone and Estradiol in normal mammary parenchymal cells. Estrone sulfate potassium stimulates the growth of nitrosomethylurea-induced mammary tumors in ovariectomized rats and the colony formation of dispersed nitrosomethylurea mammary cells, with conversion into Estrone and Estradiol occurring both in vivo and in vitro during this process. Estrone sulfate potassium is applicable to breast cancer-related research .

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Estrone sulfate sodium

3 Cited Publications

Cat. No.: HY-113293B

CAS No.: 438-67-5

Purity: 99.84%

Category:

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:

Endogenous Metabolite Estrogen Receptor/ERR

Estrone sulfate sodium is an inactive endogenous estrogen that can be converted into Estrone (HY-B0234) and Estradiol (HY-B0141). Estrone sulfate sodium is also a substrate of the OATP1B3 transporter. Estrone sulfate sodium can be converted into Estrone and Estradiol in normal mammary parenchymal cells. Estrone sulfate sodium stimulates the growth of nitrosomethylurea-induced mammary tumors in ovariectomized rats and the colony formation of dispersed nitrosomethylurea mammary cells, with conversion into Estrone and Estradiol occurring both in vivo and in vitro during this process. Estrone sulfate sodium is applicable to breast cancer-related research .

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AU-24118

3 Cited Publications

Cat. No.: HY-163410

CAS No.: 3084244-26-5

Target:

PROTACs SWI/SNF Complex Apoptosis

Research Areas:

Cancer

AU-24118 is an orally active PROTAC degrader that recruits cereblon to target the degradation of SMARCA2, SMARCA4 and PBRM1. AU-24118 impairs the chromatin accessibility of oncogenic transcription factors, inhibits colony formation, dislodges chromatin-bound transcription factors, attenuates downstream signal transduction, induces apoptosis, and exerts antiproliferative and cytotoxic effects. AU-24118 can be used in research related to castration-resistant prostate cancer, colorectal cancer, small cell lung cancer and multiple myeloma (including the t (4;14) subtype) .

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