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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
CpG methylation
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "CpG methylation" in MCE Product Catalog:
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2
2 Cited Publications
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2 Cited Publications
Cat. No.: HY-W008091
CAS No.: 554-01-8
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2 Cited Publications
Cat. No.: HY-W008091R
CAS No.: 554-01-8
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2 Cited Publications
Cat. No.: HY-W008091A
CAS No.: 58366-64-6
Research Areas:
5-Methylcytosine hydrochloride is a well-characterized DNA modification in prokaryotes and eukaryotes. 5-Methylcytosine hydrochloride forms symmetrical methylation on CpG dinucleotides in DNA, stabilizes tRNA/rRNA structure in RNA, and affects mRNA translation. 5-Methylcytosine hydrochloride can be oxidized to generate 5hmC, 5fC, and 5caC. 5-Methylcytosine hydrochloride can be used in epigenetics, developmental biology, and the study of diseases such as colorectal cancer and hepatocellular carcinoma .
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2 Cited Publications
Cat. No.: HY-W012078R
CAS No.: 838-07-3
Synonyms: 5-Methyldeoxycytidine (Standard)
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Category:
Infection Antibiotics Microorganism Disease Research Antibacterial Disease Research Fields Other Antibiotics
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1 Cited Publications
Cat. No.: HY-P1108
CAS No.: 681260-70-8
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Astressin 2B is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC50=0.57 nM). Astressin 2B blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 .
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1 Cited Publications
Cat. No.: HY-P1108A
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Cat. No.: HY-P10272
CAS No.: 1628323-80-7
Synonyms: PTG-300
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Nucleoside Antimetabolite/Analog Drug Metabolite DNA Alkylator/Crosslinker DNA/RNA Synthesis
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6-Thioguanosine (6-Mercaptoguanosine) is a ribonucleoside (nucleotide) metabolite of Azathioprine (HY-B0256). 6-Thioguanosine forms TGTP, which binds to Rac1 GTPase in an inhibitory manner, and is incorporated into newly synthesized RNA, mRNA, large/small RNA, and genomic DNA, with mRNA being the most abundant. 6-Thioguanosine inhibits the methylation of adjacent cytosines at methylated CpG sites, enhances the methylation of contralateral cytosines at unmethylated CpG sites, and inhibits the synthesis of poly (A)-containing RNA. 6-Thioguanosine does not inhibit general protein synthesis, does not cause depolymerization of polyribosomes, does not affect cytoplasmic/nuclear RNA synthesis, and does not affect RNA lacking poly (A) in the cytoplasm. 6-Thioguanosine can be used in research on acute lymphoblastic leukemia .
Cat. No.: HY-W740027
CAS No.: 1160707-78-7
Synonyms: 5-Methyldeoxycytidine-d3
Cat. No.: HY-W008091S
CAS No.: 1219795-15-9
Cat. No.: HY-P10143
CAS No.: 99828-55-4
Synonyms: Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt
Cat. No.: HY-A0248AS
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Cat. No.: HY-P10563
CAS No.: 2580150-96-3
Synonyms: BHV-1100
Cat. No.: HY-P3066
CAS No.: 77453-01-1
Synonyms: d(CH2)5Tyr(Et)VAVP
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Cat. No.: HY-P10828
CAS No.: 1260620-30-1
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Cat. No.: HY-W063263
CAS No.: 4030-18-6
Synonyms: N-Acetylpyrrolidine
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1-Acetylpyrrolidine (N-acetylpyrrolidine) is a smoking-related metabolite. 1-Acetylpyrrolidine can induce low methylation at DNA CpG site. 1-Acetylpyrrolidine can be used for the research on the mechanisms of smoking-related diseases and the development of biomarkers .
Cat. No.: HY-119499R
CAS No.: 85-31-4
Synonyms: 6-Mercaptoguanosine (Standard)
Target:
Reference Standards Nucleoside Antimetabolite/Analog Drug Metabolite DNA Alkylator/Crosslinker DNA/RNA Synthesis
Research Areas:
6-Thioguanosine (Standard) (6-Mercaptoguanosine (Standard)) is the analytical standard of 6-Thioguanosine (HY-119499). This product is intended for research and analytical applications. 6-Thioguanosine (6-Mercaptoguanosine) is a ribonucleoside (nucleotide) metabolite of Azathioprine (HY-B0256). 6-Thioguanosine forms TGTP, which binds to Rac1 GTPase in an inhibitory manner, and is incorporated into newly synthesized RNA, mRNA, large/small RNA, and genomic DNA, with mRNA being the most abundant. 6-Thioguanosine inhibits the methylation of adjacent cytosines at methylated CpG sites, enhances the methylation of contralateral cytosines at unmethylated CpG sites, and inhibits the synthesis of poly (A)-containing RNA. 6-Thioguanosine does not inhibit general protein synthesis, does not cause depolymerization of polyribosomes, does not affect cytoplasmic/nuclear RNA synthesis, and does not affect RNA lacking poly (A) in the cytoplasm. 6-Thioguanosine can be used in research on acute lymphoblastic leukemia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
