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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
Cryptosporidium
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "Cryptosporidium" in MCE Product Catalog:
2
2 Cited Publications
Synonyms: Dibromohydroxyquinoline; 5,7-Dibromo-8-hydroxyquinoline
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Broxyquinoline (Dibromohydroxyquinoline) is an effective inhibitor of severe fever with thrombocytopenia syndrome virus (SFTSV) with an IC50 of 5.8 µM. Additionally, Broxyquinoline is an inhibitor of CpACBP1 with an IC50 of 64.9 μM. CpACBP1 is a fatty acyl-CoA binding protein of Cryptosporidium parvum, thus Broxyquinoline has the potential to inhibit parasite growth. Broxyquinoline shows promise for research in the field of infectious diseases .
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2 Cited Publications
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LysRs-IN-2 is a lysyl-tRNA synthetase (KRS) inhibitor with IC50s of 0.015 μM and 0.13 μM for Plasmodium falciparum lysyl-tRNA synthetase (PfKRS) and Cryptosporidium parvum lysyl-tRNA synthetase (CpKRS), respectively .
1
1 Cited Publications
Synonyms: Lentinacin; D-Eritadenine; Lentysine
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Eritadenine (D-Eritadenine) is a potent AdoHcyase inhibitor, with an IC50 value of 7 nM. Eritadenine is also an acyclic sugar adenosine analogue. Eritadenine exhibits an inhibitory effect on the growth of Cryptosporidium parvum, with a MIC50 of 3 μM. Eritadenine can be used in the research of colorectal adenocarcinoma .
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1 Cited Publications
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EDI048 is an orally active, gut-restricted parasiticidal agent. EDI048 specifically binds to the ATP-binding site of Cryptosporidium phosphatidylinositol 4-kinase (CpPI (4) K), blocks parasite membrane biogenesis, arrests the pathogen at the schizont stage, and thus irreversibly clears the infection. EDI048 is rapidly converted to an inactive carboxylic acid metabolite via hepatic first-pass metabolism, with extremely low systemic exposure, good safety profile, and no cardiotoxicity, genotoxicity or off-target effects. EDI048 is used in studies of intestinal cryptosporidiosis in children .
Category:
Human Gut Microbiota Metabolites Polysaccharides Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides
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Cat. No.: HY-W011517
CAS No.: 146-78-1
Synonyms: 2FA
AN7973 is the 6-carboxamide benzoxaborole, blocks intracellular parasite development and inhibits Cryptosporidium growth. AN7973 is orally active, possesses favorable safety, stability, and PK parameters, and is an exciting agent candidate for treating cryptosporidiosis.
KDU731, an orally active C. parvum PI4K inhibitor with an IC50 value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo . KDU731 is a promising agent candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety .
Cat. No.: HY-168569
CAS No.: 3003871-42-6
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DDD489 is a potent and selective Cryptosporidium lysyl-tRNA synthetase (CpKRS) inhibitor with IC50 values of 0.85 uM.DDD489 shows anti-cryptosporidials activity in vitro and in vivo .
Cat. No.: HY-165555
CAS No.: 904576-65-4
MMV665917 is an orally active piperazine derivative with anti-Cryptosporidium parvum activity with an EC90 of 15 μM. MMV665917 significantly reduces the parasite load in a porcine model infected with C. hominis, decreases ovarian excretion, alleviates diarrhea symptoms and reduces intestinal mucosal damage. MMV665917 can be used for research on Cryptosporidium parvum disease .
Cat. No.: HY-120489
CAS No.: 1185388-35-5
A110 is the inhibitor for Cryptosporidium parvum inosine monophosphate dehydrogenase (CpIMPDH). A110 inhibits CpIMPDH in Toxoplasma gondii with IC50 of 18 nM. A110 exhibits pro-parasitic efficacy and cause parasitemia .
Cat. No.: HY-118421
CAS No.: 300816-11-9
Nullscript is a negative control for Scriptaid. Nullscript is a known inactive analog of Scriptaid . Scriptaid is a representative HDAC inhibitor . Nullscript inhibits Cryptosporidium (C. parvum) growth with the IC50 value of 2.1 μM .
Cat. No.: HY-W011517R
CAS No.: 146-78-1
Synonyms: 2FA (Standard)
Cat. No.: HY-158776
CAS No.: 2755451-45-5
SLU-10482 is an orally active anti-parasitic agent, that inhibits Cryptosporidium parvum with an IC50 of 0.0687 μM. SLU-10482 exhibits anti-infective efficacy in C. parvum infected mice with an AC50 of 0.0686 μM .
Cat. No.: HY-170777
CAS No.: 3065121-94-7
SLU-10906 (Compound 63) is an orally active and potent Cryptosporidium inhibitor. SLU-10906 is active against the parasite in a cell-based infection model (EC50= 0.19 μM) and non-cytotoxic. SLU-10906 is promising for research of cryptosporidiosis .
Cat. No.: HY-103583R
CAS No.: 1610610-48-4
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Research Areas:
KDU731 (Standard) is the analytical standard of KDU731 (HY-103583). This product is intended for research and analytical applications. KDU731, an orally active C. parvum PI4K inhibitor with an IC50 value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo . KDU731 is a promising agent candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety .
Cat. No.: HY-189004
CAS No.: 3065121-95-8
SLU-11695 is an orally active antiparasitic agent belonging to the pyrazolo[3,4-d]pyrimidine benzoxaborole class. SLU-11695 inhibits the asexual reproduction of Cryptosporidium parvum, eliminates parasite shedding, and prevents post-exposure recurrence. SLU-11695 can be used in the research of cryptosporidiosis .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
