171

171 Publications Verification

Synonyms: Sulfobutylether-β-Cyclodextrin

SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble agents .

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131

Methyl-β-cyclodextrin

131 Cited Publications

Cat. No.: HY-101461

CAS No.: 128446-36-6

Purity: 99.95%

Synonyms: Methyl-beta-cyclodextrin

Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic agents based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent . Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis . Methyl-β-cyclodextrin blocks cell migrasome formation .

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102

Cholesterol (Water Soluble)

102 Cited Publications

Cat. No.: HY-N0322A

Category:

Lipids Endogenous metabolite

Target:

Liposome

Cholesterol Water Soluble is a major sterol in mammals, constituting 20-25% of the structural composition of the plasma membrane. The plasma membrane is highly permeable to water but relatively impermeable to ions and protons. Cholesterol Water Soluble plays an important role in determining the fluidity and permeability characteristics of membranes and the function of transporters and signaling proteins. Cholesterol Water Soluble is also an endogenous estrogen-related receptor alpha (ERRα) agonist. Cholesterol Water Soluble can be used to study the effects of cholesterol on potassium currents in inner hair cells .
(Note: This product is a mixture of Cholesterol and Methyl-β-cyclodextrin. The product specifications below only indicate the effective content of Cholesterol.)

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37

HP-β-CD

37 Cited Publications

Cat. No.: HY-101103

CAS No.: 128446-35-5

Purity: 99.74%

Synonyms: (2-Hydroxypropyl)-β-cyclodextrin

HP-β-CD ((2-Hydroxypropyl)-β-cyclodextrin) is a widely used drug delivery vehicle to improve the stability and bioavailability.

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35

Cyclo(-RGDfK)

35 Cited Publications

Cat. No.: HY-P0023

CAS No.: 161552-03-0

Target:

Integrin

Research Areas:

Cancer

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC₅₀ of 0.94 nM. Cyclo(-RGDfK) potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .

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35

Cyclo(-RGDfK) TFA

35 Cited Publications

Cat. No.: HY-P0023A

CAS No.: 500577-51-5

Target:

Integrin

Research Areas:

Cancer

Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the α_vβ₃ integrin, with an IC₅₀ of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .

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17

Alisporivir

17 Cited Publications

Cat. No.: HY-12559

CAS No.: 254435-95-5

Purity: 98.08%

Synonyms: Debio-025; DEB-025

Target:

Cyclophilin HCV

Research Areas:

Infection

Alisporivir (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity.

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13

β-Cyclodextrin

13 Cited Publications

Cat. No.: HY-107201

CAS No.: 7585-39-9

Purity: 99.95%

Synonyms: Betadex

Target:

Influenza Virus

Research Areas:

Infection

β-Cyclodextrin is a cyclic polysaccharide composed of seven units of glucose (α-D-glucopyranose) linked by α-(1,4) type bonds. β-Cyclodextrin has often been used to enhance the solubility of agents. β-Cyclodextrin has anti-influenza virus H1N1 activities.

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8

Cyclo(Phe-Pro)

8 Cited Publications

Cat. No.: HY-P1934

CAS No.: 14705-60-3

Synonyms: Cyclo(phenylalanylprolyl); A-64863

Target:

HCV Bacterial Antibiotic Reactive Oxygen Species (ROS)

Research Areas:

Infection

Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) is a quorum-sensing molecule of Vibrio vulnificus that specifically interacts with RIG-I, inhibiting RIG-I polyubiquitination, suppressing IRF-3 activation, and reducing type I interferon production. Cyclo(Phe-Pro) enhances susceptibility to HCV and influenza virus and also alleviates plant aluminum toxicity stress. The mechanism of Cyclo(Phe-Pro) involves the regulation of host immune signaling pathways, bacterial virulence gene expression, and plant antioxidant systems, making it a promising candidate for research in viral infections, bacterial virulence regulation, and agricultural stress resistance .

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