1 Result for "

D 22888

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "D 22888" in MCE Product Catalog:

Cat. No.: HY-183463
CAS No.: 182282-60-6
Research Areas:  

Inflammation/Immunology

D 22888 is an orally active PDE4 inhibitor, with human PDE4 IC50 of 0.153 μM, and selectivity over PDE3 and PDE5. D 22888 elevates intracellular cAMP levels to modulate target cell functions. D 22888 acts as a relaxant of human bronchial ring inherent tone. D 22888 inhibits opsonized zymosan-induced superoxide anion generation by human eosinophils. D 22888 reduces bronchoalveolar lavage eosinophil numbers in allergen-challenged sensitized guinea pigs via single or chronic oral dosing. D 22888 can be used for the research of bronchial asthma .
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