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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
50 Results for "
D3 ligands
" in MedChemExpress (MCE) Product Catalog:
Products (50)
50 Results for "D3 ligands" in MCE Product Catalog:
15
Category:
Natural Products Other disease Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields
Target:
15
15 Publications Verification
Cat. No.: HY-32351A
CAS No.: 63283-36-3
Synonyms: 25-hydroxy Vitamin D3 monohydrate
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1
1 Cited Publications
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ZK159222, a 25-carboxylic ester analogue of 1α,25-(OH)2D3, is a potent 1α,25-(OH)2D3 receptor (VDR) antagonist. The mechanism of ZK159222 antagonistic action is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators. ZK159222 has a partial agonistic character .
1
1 Cited Publications
Cat. No.: HY-32351S
CAS No.: 140710-94-7
Synonyms: 25-Hydroxy Vitamin D3-d3
Synonyms: 25-hydroxy Vitamin D3-d6
Cat. No.: HY-N0368S
CAS No.: 1216673-02-7
Cat. No.: HY-B0932S
CAS No.: 1334532-19-2
Synonyms: L-Propionylcarnitine-d3 chloride; ST-261-d3
Cat. No.: HY-N10508
CAS No.: 71204-89-2
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Cat. No.: HY-32351R
CAS No.: 19356-17-3
Synonyms: 25-hydroxy Vitamin D3 (Standard)
Category:
Alkaloids Plant Monophenols Other Diseases Phenols Other Families Extract Disease Research Fields Isoquinoline Alkaloids
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Cat. No.: HY-P11035
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Research Areas:
APY-d3 is a highly selective EphA4 receptor inhibitor, with an IC50 value of 17-56 nM for human EphA4, an IC50 value of 20 nM for mouse EphA4, and a Kd value of 138 nM for EphA4-LBD. APY-d3 binds to EphA4, blocks its interaction with ephrin ligands, inhibits tyrosine phosphorylation of EphA4, prevents growth cone collapse, and does not induce EphA4 phosphorylation in primary cortical neurons. APY-d3 adopts a β-hairpin conformation stabilized by an N-terminal to C-terminal disulfide bond. APY-d3 can be used in research related to amyotrophic lateral sclerosis, Alzheimer's disease, stroke, neurodegenerative diseases and cancer .
Synonyms: (Rac)-Naproxen-d3
Target:
(±)-Naproxen-d3 ((Rac)-Naproxen-d3) is the deuterated-labeled (±)-Naproxen (HY-15029). (±)-Naproxen ((Rac)-Naproxen) is the racemate of Naproxen (HY-15030), consisting of R- and S-enantiomers. (±)-Naproxen binds to AKR1C3, which preferentially recognizes the R-enantiomer from the racemic mixture. It is used for AKR1C3 stereoselective ligand recognition and studies on NSAID binding mechanisms .
Cat. No.: HY-32351AS
CAS No.: 2483831-70-3
Synonyms: 25-hydroxy Vitamin D3-d6 monohydrate
Research Areas:
Fluoroclebopride is a Dopamine receptor ligand with a binding Ki of 0.95 nM for the dopamine D2 receptor and a binding Ki of 5.46 nM for the dopamine D3 receptor. When radiolabeled with 18F, Fluoroclebopride can be used to detect the availability of dopamine D2 and D3 receptors in the caudate nucleus and putamen of primates .
Cat. No.: HY-W777599
CAS No.: 1216704-11-8
Synonyms: (Rac)-Naproxen-13C,d3-1
Target:
(±)-Naproxen- 13C,d3-1 ((Rac)-Naproxen- 13C,d3-1) is the deuterated, 13C-labeled (±)-Naproxen (HY-15029). (±)-Naproxen ((Rac)-Naproxen) is the racemate of Naproxen (HY-15030), consisting of R- and S-enantiomers. (±)-Naproxen binds to AKR1C3, which preferentially recognizes the R-enantiomer from the racemic mixture. It is used for AKR1C3 stereoselective ligand recognition and studies on NSAID binding mechanisms .
Cat. No.: HY-115954
CAS No.: 2882828-95-5
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Research Areas:
Dopamine D3 receptor ligand-2 (compound 8) is a potent D3 receptor ligand with a Ki of 11.4 nM. Dopamine D3 receptor ligand-2 have high selectivity for D3 over D2 (Ki=1228 nM) .
Cat. No.: HY-115955
CAS No.: 2891605-81-3
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Research Areas:
Dopamine D3 receptor ligand-3 (compound 12C) is a potent D3 receptor ligand with a Ki of 3.6 nM. Dopamine D3 receptor ligand-3 have high selectivity for D3 over D2 (Ki=353 nM).
Cat. No.: HY-174307
CAS No.: 687634-09-9
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Research Areas:
Dopamine D3 receptor ligand-6 (Compound 196476) is a selective dopamine D3 receptor (D3) antagonist. Dopamine D3 receptor ligand-6 is promising for research of substance use disorders (such as opioid and psychostimulant addiction) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
