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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
29 Results for "
D4R
" in MedChemExpress (MCE) Product Catalog:
Products (29)
29 Results for "D4R" in MCE Product Catalog:
2
2 Cited Publications
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Aripiprazole lauroxil, an N-acyloxymethyl proagent of Aripiprazole (HY-14546), is a Long-acting injectable (LAI) typical antipsychotic for schizophrenia and a ligand of dopamine receptor D2R/D4R. Aripiprazole lauroxil is cleaved by body’s enzyme esterase to N-hydroxymethyl aripiprazole (plus lauric acid) and then to aripiprazole (plus formaldehyde), no toxicity.
Cat. No.: HY-163703
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D4R antagonist-2 (compound 33) is a D4R antagonist. D4R antagonist-2 has a IC50 value of 210 nM, and a Ki value of 59 nM for D4R. D4R antagonist-2 can be used in the Parkinson's disease research .
Cat. No.: HY-149481
CAS No.: 2826198-44-9
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D4R agonist-1 (Compound 16f) is a D4R partial agonist (Ki: 2.2 nM). D4R agonist-1 is metabolically stable in rat and human liver microsomes. D4R agonist-1 can be used for research of neuropsychiatric disorders .
Cat. No.: HY-145905
CAS No.: 2846077-19-6
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D4R antagonist-1 is a potent and selective D4R antagonist with an IC50 of 6.87 µM. D4R antagonist-1 has the potential for the research of Parkinson’s disease .
Cat. No.: HY-145906
CAS No.: 2846077-70-9
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D4R antagonist-2 is a potent and selective D4R antagonist with an IC50 of 6.52 µM. D4R antagonist-2 displays very favorable in vitro PK parameters and has good brain penetration. D4R antagonist-2 has the potential for the research of Parkinson’s disease .
Synonyms: R 64 766-d4
Cat. No.: HY-130203
CAS No.: 1379510-21-0
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Dopamine D4R antagonist-1 is a blood-brain barrier-permeable antagonist of dopamine D4 receptor. Dopamine D4R antagonist-1 functionally inhibits dopamine D4 receptor, exhibits only weak activity against dopamine D3 receptor, and shows no activity against dopamine D1 and D2 receptors .
Cat. No.: HY-175504
CAS No.: 932544-59-7
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MLS6357 is a D3 dopamine receptor (D3R)-selective positive allosteric modulator (PAM)-antagonist. MLS6357 exhibits antagonist activity in the D3R-mediated and the BRET-based β-arrestin recruitment assay with IC50s of 13 and 14 μM, and no activity for other DAR subtypes (D1R/D2R/D4R/D5R) (IC50 > 100 μM). MLS6357 is also an antagonist in the D3R-mediated Go-BRET assay with an IC50 of 17 μM. MLS6357 can be used for the study of neuropsychiatric disorders, including substance use disorder .
Cat. No.: HY-B0105S1
CAS No.: 1398065-75-2
Synonyms: Ketoconazol-d4; R 41400-d4
Cat. No.: HY-90005S
CAS No.: 1142095-93-9
Synonyms: TMC-125 d4; R-165335 d4
Cat. No.: HY-13662BS
Purity: 99.13%
Synonyms: Dexlansoprazole-d4
Cat. No.: HY-108751R
CAS No.: 1259305-29-7
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Aripiprazole Lauroxil (Standard) is the analytical standard of Aripiprazole Lauroxil. This product is intended for research and analytical applications. Aripiprazole lauroxil, an N-acyloxymethyl proagent of Aripiprazole (HY-14546), is a Long-acting injectable (LAI) typical antipsychotic for schizophrenia and a ligand of dopamine receptor D2R/D4R. Aripiprazole lauroxil is cleaved by body’s enzyme esterase to N-hydroxymethyl aripiprazole (plus lauric acid) and then to aripiprazole (plus formaldehyde), no toxicity.
Cat. No.: HY-B1470S
CAS No.: 1173021-72-1
Synonyms: R-1929-d4
Cat. No.: HY-173431
CAS No.: 3082344-46-2
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Dopamine D4 receptor ligand 3 (Compound 16) is a dopamine D4 receptor (D4R) antagonist (pKi: 8.86). Dopamine D4 receptor ligand 3 has pIC50 values of 5.78, 5.55, and 6.17 for Go, Gi, and βArr2 sensors in HEK-293T cells, respectively. Dopamine D4 receptor ligand 3 inhibits the viability of three human glioma cell lines, U87 MG, T98G, and U251 MG. Dopamine D4 receptor ligand 3 induces ROS production and mitochondrial dysfunction in glioma cells .
Cat. No.: HY-18733S
CAS No.: 1448263-85-1
Synonyms: (R)-(+)-α-Lipoic acid-d4; R-(+)-Thioctic acid-d4
Cat. No.: HY-101384
CAS No.: 189744-46-5
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Ro 10-5824 is a potent and selective D4R partial agonist with a Ki of 5.2 nM. Ro 10-5824 increases novel object exploration in C57 mice .
Cat. No.: HY-RS04004
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Drd4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Drd4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-181049
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FMJ-01-054 is a selective dopamine D4 Receptor (D4R) antagonist with a Ki od 77.7 nM. FMJ-01-054 shows subtype selectivity over D2R and D3R. FMJ-01-054 inhibits D4R-mediated β-arrestin recruitment and cAMP production with IC50 values of 3800 nM and 134 nM, respectively. FMJ-01-054 has desirable plasma half-life and brain exposure in rats. FMJ-01-054 can be used for the research of neurological disorders .
Cat. No.: HY-187840
CAS No.: 194038-94-3
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RBI257 is a selective dopamine D4R antagonist with a pKi of 8.42 for the hD4.4 receptor. RBI257 acts as a competitive antagonist at the hD4.4 receptor, blocking dopamine-stimulated G protein activation and GIRK current activation. RBI257 can be used for research on hypertension and schizophrenia .
Cat. No.: HY-W719281
Synonyms: Pantetheine-d4
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
