1 Result for "

D8P1C1

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "D8P1C1" in MCE Product Catalog:

D8P1C1
D8P1C1
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Cat. No.: HY-P992341

Target:  

MMP

Research Areas:  

Cancer

D8P1C1 is a high-affinity ADAM17 inhibitor (with a Kd of 180 pM targeting ADAM17-ECD) that reduces the shedding and phosphorylation of EGFR ligands. D8P1C1 inhibits cancer cell proliferation in vitro and tumor growth in xenograft models. 89Zr-DFO-D8P1C1 radioimmunological PET imaging shows its substantial accumulation in ovarian tumor xenografts, serving as a platform for generating bispecific T-cell engager derivatives. D8P1C1 can be applied to research on related diseases including triple-negative breast cancer, various types of ovarian cancer, lung adenocarcinoma, glioma, and colon cancer .
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