Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
DCAF11-dependent
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "DCAF11-dependent" in MCE Product Catalog:
Target:
Research Areas:
PROTAC BET Degrader-12 (Compound 8b) is a PROTAC degrader for bromodomain and extra-terminal domain (BET)-containing proteins, which degrades the BRD3 and BRD4 in a DCAF11-dependent manner. PROTAC BET Degrader-12 inhibits cell viability of KBM7 with a DC50 of 305.2 nM
Cat. No.: HY-189123
CAS No.: 724429-20-3
Target:
Research Areas:
M12 is a DCAF11-dependent molecular glue degrader activated by glutathionylation, which induces CRL4 DCAF11-mediated degradation of DDX18. M12 is a precursor compound that requires metabolic activation: it is conjugated with glutathione (GSH) under the catalysis of glutathione S-transferase (GST) to form GSH-M12, which interacts with DCAF11 and promotes the recruitment of DDX18. M12 is applicable for studies on targeted protein degradation and DCAF11-dependent molecular glue mechanisms .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
