14 Results for "

DENV serotypes

" in MedChemExpress (MCE) Product Catalog:
Products (14)

14 Results for "DENV serotypes" in MCE Product Catalog:

NITD-688
NITD-688
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Cat. No.: HY-138543
CAS No.: 2407227-31-8
Purity:  99.00%
Synonyms: EYU-688
Target:  

Flavivirus Dengue Virus Virus Protease

Research Areas:  

Infection

NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the research of dengue virus (DENV) .
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Mosnodenvir
Mosnodenvir
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Cat. No.: HY-153810
CAS No.: 2890688-86-3
Purity:  99.31%
Synonyms: JNJ-1802
Target:  

Virus Protease Flavivirus Dengue Virus

Research Areas:  

Infection

Mosnodenvir (JNJ-1802) is an orally active pan serotype dengue virus (DENV) inhibitor, with EC50 values ranging from 0.057 to 11 nM for four dengue virus (DENV) serotypes. Mosnodenvir blocks viral replication by inhibiting the formation of complexes between two viral proteins, nonstructural protein 3 (NS3) and NS4B, thereby preventing the formation of new viral RNA. Mosnodenvir exhibits picomolar to nanomolar antiviral activity in vitro and has antiviral efficacy in mice and non-human primates .
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BP13944
BP13944
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Cat. No.: HY-136797
CAS No.: 1622060-51-8
Target:  

Dengue Virus

Research Areas:  

Infection

BP13944 is a potential small molecule inhibitor discovered by high-throughput screening. It can effectively inhibit the expression of dengue virus (DENV) replicons with an EC50 value of 1.03±0.09 μM. BP13944 can inhibit the replication or viral RNA synthesis of all four serotypes of DENV, but is ineffective against Japanese encephalitis virus. BP13944 may target the DENV NS3 protease, and the E66G amino acid substitution in the NS3 protease region will cause the virus to become resistant to BP13944. BP13944 has no obvious cytotoxicity. As there is currently no effective dengue vaccine and treatment, BP13944, as an effective small molecule inhibitor, may become a potential agent for the treatment of dengue in the future.
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Sinococuline
Sinococuline
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Cat. No.: HY-N11096
CAS No.: 109351-36-2
Category:  

Alkaloids Piperidine Alkaloids Menispermaceae Extract Plants 500 - Internal Server Error | MedChemExpress

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